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18 条记录 (耗时 0.02 秒)

    Immune suppressor and its use
    4.
    发明公开
    Immune suppressor and its use 审中-公开
    免疫抑制剂和Seine Verwendung

    公开(公告)号：EP2502631A1

    公开(公告)日：2012-09-26

    申请号：EP11159203.6

    申请日：2011-03-22

    申请人： Medizinische Hochschule Hannover

    发明人： Kay-Fedonov, Penelope ,  Steinbrück, Lars ,  Gabaev, Ildar ,  Messerle, Martin ,  Schulz, Thomas F.

    IPC分类号： A61K38/16 ,  G01N33/50

    CPC分类号： G01N33/505 ,  A61K38/162 ,  C07K14/005 ,  C07K2319/30 ,  C12N2710/10041 ,  C12N2710/16111 ,  C12N2740/10041 ,  G01N33/5052 ,  G01N2333/045 ,  G01N2333/70589 ,  G01N2800/24

    摘要： The present invention relates to a new binder molecule useful e.g. as an immune suppressor. In particular, it has been recognized that the UL11 protein of human the cytomegalovirus, binds to the CD45 molecule, potentially altering the immune system of an individual. In addition, the present invention relates to binder molecules, in particular, fusion molecules containing the CD45 binding domain of the UL11 protein in combination with a second molecule of interest for delivery of said molecule to cells expressing the CD45 molecule. Moreover, the present invention relates to pharmaceutical compositions comprising the UL11 protein of human cytomegalovirus, or derivatives or homologs thereof, or a nucleic acid sequence encoding the same.

    摘要翻译： 本发明涉及一种新的粘合剂分子， 作为免疫抑制剂。 特别地，已经认识到人巨细胞病毒的UL11蛋白与CD45分子结合，潜在地改变个体的免疫系统。 此外，本发明涉及粘合剂分子，特别地涉及含有UL11蛋白的CD45结合结构域的融合分子与目的用于将所述分子递送至表达CD45分子的细胞的目标第二分子的组合。 此外，本发明涉及包含人巨细胞病毒的UL11蛋白或其衍生物或同系物或其编码的核酸序列的药物组合物。

    METHOD FOR PRODUCING VIRAL VECTOR
    6.
    发明公开
    METHOD FOR PRODUCING VIRAL VECTOR 审中-公开
    VERFAHREN ZUR HERSTELLUNG VON VIRALEN VEKTOREN

    公开(公告)号：EP2829606A1

    公开(公告)日：2015-01-28

    申请号：EP13763874.8

    申请日：2013-03-14

    申请人： Takara Bio, Inc.

    发明人： SHINMURA, Kazuhisa ,  YOSHIOKA, Hirofumi ,  TAKAKURA, Hikaru ,  MINENO, Junichi

    IPC分类号： C12N15/09 ,  A61K48/00 ,  C12N5/10

    CPC分类号： C12N15/86 ,  A61K35/13 ,  A61K48/00 ,  C12N5/0018 ,  C12N7/00 ,  C12N2740/10041 ,  C12N2740/10051 ,  C12N2740/10052

    摘要： The present invention provides a method for producing a virus vector, which involves a step of culturing a cell capable of producing the virus vector in a culture medium containing a retinoic acid compound, a histone deacetylase-inhibiting substance and a substance capable of forming a chelate; and a culture medium for use in the production of a virus vector, which is characterized by containing a retinoic acid compound, a histone deacetylase-inhibiting substance and a substance capable of forming a chelate as active ingredients.

    摘要翻译： 本发明提供一种病毒载体的制备方法，其包括在含有维甲酸化合物，组蛋白脱乙酰酶抑制物质和能够形成螯合物的培养基中培养能够产生病毒载体的细胞的步骤 ; 以及用于生产病毒载体的培养基，其特征在于含有视黄酸化合物，组蛋白脱乙酰酶抑制物质和能够形成螯合物的物质作为活性成分。