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公开(公告)号：EP1371724B1
公开(公告)日：2008-10-15
申请号：EP02705116.8
申请日：2002-03-13
申请人： TAKARA BIO INC.
CPC分类号： C07K14/195
摘要： Isolated DNAs which are DNAs having a base sequence represented by any of SEQ ID NOS:1 to 6 in Sequence Listing or fragments thereof and showing a stationary phase-specific promoter activity in gram positive bacteria.
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公开(公告)号：EP1318197B1
公开(公告)日：2008-10-15
申请号：EP01965599.2
申请日：2001-09-13
申请人： TAKARA BIO INC.
发明人： UEMORI, Takashi , SATO, Yoshimi , KOYAMA, Nobuto , HIRANO, Ryo, c/o TAKARA BIO INC. , TAKAKURA, Hikaru , KOBORI, Hiroshi , HASHIMOTO, Yuji , ASADA, Kiyozo , KATO, Ikunoshin
CPC分类号： C12N9/22
摘要： Polypeptides having an RNase H activity highly useful in genetic engineering; genes encoding these polypeptides; and a process for genetic engineeringly producing these polypeptides.
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公开(公告)号：EP1371724A1
公开(公告)日：2003-12-17
申请号：EP02705116.8
申请日：2002-03-13
申请人： TAKARA BIO INC.
CPC分类号： C07K14/195
摘要： Isolated DNAs which are DNAs having a base sequence represented by any of SEQ ID NOS:1 to 6 in Sequence Listing or fragments thereof and showing a stationary phase-specific promoter activity in gram positive bacteria.
摘要翻译： 分离的DNA是具有由序列表中SEQ ID NO：1至6中任一个表示的碱基序列的DNA或其片段，并且在革兰氏阳性细菌中显示出稳定的相特异性启动子活性。
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公开(公告)号：EP3168298B1
公开(公告)日：2019-04-17
申请号：EP15819589.1
申请日：2015-07-09
申请人： Takara Bio Inc.
发明人： NISHIE, Toshikazu , KAWANO, Yasuhiro , SAKAMOTO, Shuhei , ENOKI, Tatsuji , TAKAKURA, Hikaru , MINENO, Junichi
IPC分类号： C12N7/02
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5.发明公开METHOD FOR PRODUCING T CELL POPULATION UNDER PRESENCE OF RETINOIC ACID 审中-公开VERFAHREN ZUR HERSTELLUNG EINER T-ZELLEN人口统计VERWENDUNG VON RETINSURE
公开(公告)号：EP2471901A1
公开(公告)日：2012-07-04
申请号：EP10811841.5
申请日：2010-08-24
申请人： Takara Bio, Inc.
发明人： KATAYAMA, Yoshinori , SAKAI, Kensuke , YOSHIOKA, Hirofumi , TAKAKURA, Hikaru , CHONO, Hideto , SAITO, Naoki , MINENO, Junichi
CPC分类号： C12N5/0636 , C12N2501/385 , C12N2501/515 , C12N2501/58 , C12N2510/00
摘要： Disclosed is a method for producing a cell population containing memory-like T cells, said method being characterized by including a step for in vitro culturing of a cell population containing T cells or T cell precursor cells using a retinoic acid and a CD3 ligand. Further disclosed is a method for producing a cell population wherein the proportion of memory-like T cells is increased and wherein a desired gene is introduced with a high efficiency and is highly expressed.
摘要翻译： 公开了一种生产含有记忆样T细胞的细胞群的方法，所述方法的特征在于包括使用视黄酸和CD3配体体外培养含有T细胞或T细胞前体细胞的细胞群的步骤。 进一步公开了一种生产细胞群的方法，其中记忆样T细胞的比例增加，并且其中以高效率引入所需基因并高度表达。
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公开(公告)号：EP3020808B1
公开(公告)日：2019-09-11
申请号：EP14823074.1
申请日：2014-07-10
申请人： Takara Bio Inc.
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公开(公告)号：EP3168298A1
公开(公告)日：2017-05-17
申请号：EP15819589.1
申请日：2015-07-09
申请人： Takara Bio Inc.
发明人： NISHIE, Toshikazu , KAWANO, Yasuhiro , SAKAMOTO, Shuhei , ENOKI, Tatsuji , TAKAKURA, Hikaru , MINENO, Junichi
IPC分类号： C12N7/02
CPC分类号： C12N7/00 , C12N7/02 , C12N2750/14151
摘要： Provided are a production method for non-enveloped virus particles which is characterized in that a sample including non-envelopes virus particles is treated with PEG in at least two concentrations; a kit used in said production method; non-enveloped virus particles produced using said production method; and a pharmaceutical composition having the non-envelopes virus particles as an active ingredient.
摘要翻译： 提供了一种无包膜病毒颗粒的生产方法，其特征在于包含非包膜病毒颗粒的样品用至少两种浓度的PEG处理; 所述生产方法中使用的试剂盒; 使用所述生产方法生产的无包膜病毒颗粒; 以及具有非包膜病毒颗粒作为活性成分的药物组合物。
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公开(公告)号：EP2829606A1
公开(公告)日：2015-01-28
申请号：EP13763874.8
申请日：2013-03-14
申请人： Takara Bio, Inc.
CPC分类号： C12N15/86 , A61K35/13 , A61K48/00 , C12N5/0018 , C12N7/00 , C12N2740/10041 , C12N2740/10051 , C12N2740/10052
摘要： The present invention provides a method for producing a virus vector, which involves a step of culturing a cell capable of producing the virus vector in a culture medium containing a retinoic acid compound, a histone deacetylase-inhibiting substance and a substance capable of forming a chelate; and a culture medium for use in the production of a virus vector, which is characterized by containing a retinoic acid compound, a histone deacetylase-inhibiting substance and a substance capable of forming a chelate as active ingredients.
摘要翻译： 本发明提供一种病毒载体的制备方法，其包括在含有维甲酸化合物，组蛋白脱乙酰酶抑制物质和能够形成螯合物的培养基中培养能够产生病毒载体的细胞的步骤 ; 以及用于生产病毒载体的培养基，其特征在于含有视黄酸化合物，组蛋白脱乙酰酶抑制物质和能够形成螯合物的物质作为活性成分。
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公开(公告)号：EP0994191B1
公开(公告)日：2006-03-01
申请号：EP98923114.7
申请日：1998-06-04
申请人： TAKARA BIO INC.
CPC分类号： C12N15/75 , C07K2319/02 , C12N9/52
摘要： A hyperthermostable protease having the amino acid sequence represented by the SEC ID NO:1 of the Sequence Listing or a sequence derived therefrom by deletion, substitution, insertion or addition of one to several amino acid residues, a gene encoding the hyperthermostable protease, and a process for preparing the protease, aiming at providing by genetic engineering techniques a hyperthermophile protease which is advantageous for industrial use.
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公开(公告)号：EP3020808A1
公开(公告)日：2016-05-18
申请号：EP14823074.1
申请日：2014-07-10
申请人： Takara Bio Inc.
发明人： SAKAMOTO, Shuhei , KAWANO, Yasuhiro , DODO, Katsuyuki , ENOKI, Tatsuji , YOSHIOKA, Hirofumi , TAKAKURA, Hikaru , MINENO, Junichi
CPC分类号： C12N7/00 , C12N2750/14151 , C12N15/86 , C12N2750/14143 , C12N2750/14043 , C12N2750/14122 , C12N2750/14142 , C12N7/02 , C12N2750/14141 , C12N2750/14351 , C12N2800/50 , C12N15/8673 , C12N2750/14352 , C12N2750/14152
摘要： The present invention provides a method for efficiently manufacturing a non-enveloped virus with high purity without laborious operation by cultivating cells having the ability to produce a non-enveloped virus and bringing the cells and an acidic solution into contact with each other. A non-enveloped virus vector manufactured by the method of the present invention and a composition having the non-enveloped viral vector as an active ingredient are very useful as gene transfer methods in the fields of basic research and clinical application gene therapy.
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