公开(公告)号：EP2986718A1

公开(公告)日：2016-02-24

申请号：EP14723482.7

申请日：2014-04-18

申请人： Institut National de la Recherche Agronomique (INRA)

发明人： DELMAS, Bernard

IPC分类号： C12N7/04 ,  A61K39/145 ,  C07K14/005

CPC分类号： C12N7/00 ,  A61K39/12 ,  A61K39/145 ,  A61K2039/525 ,  A61K2039/5254 ,  C07K14/005 ,  C12N7/04 ,  C12N2760/16034 ,  C12N2760/16062 ,  C12N2760/16121 ,  C12N2760/16134 ,  C12N2760/16151 ,  C12N2760/16162 ,  C12N2760/16262 ,  C12N2760/16321 ,  C12N2760/16362

摘要： The invention relates to thermosensitive mutants of influenza viruses, containing at least one mutation localised in a flexible region of a protein of said virus, such as especially the region of the sub-unit PA of the viral polymerase corresponding to the region 197-225 of the sub-unit PA of influenza A. These viruses can be especially used for preparing attenuated living vaccines.