公开(公告)号：EP2571367A4

公开(公告)日：2014-01-01

申请号：EP11783849

申请日：2011-04-04

申请人： ZHANG WEIDONG ,  JIANG LIXIAN ,  CAO CALVIN

发明人： ZHANG WEIDONG ,  JIANG LIXIAN ,  CAO CALVIN

IPC分类号： C12N7/00 ,  A61K35/76

CPC分类号： A61K39/155 ,  A61K35/76 ,  A61K35/768 ,  C12N7/00 ,  C12N2760/18032 ,  C12N2760/18511 ,  C12N2760/18532 ,  C12N2760/18543

摘要： The invention discloses an engineered oncolytic respiratory syncytial virus (RSV), NS1 gene deficient RSV, and its usage to treat breast cancer by killing cancer cells with in vitro and in vivo evidences.

公开(公告)号：EP2579884A1

公开(公告)日：2013-04-17

申请号：EP11726102.4

申请日：2011-06-09

申请人： Intervet International B.V.

发明人： SCHRIER, Carla Christina ,  JAGT, Henricus Johannes Maria

IPC分类号： A61K35/76 ,  A61K39/42 ,  A61P35/00

CPC分类号： A61K35/76 ,  A61K35/768 ,  A61K45/06 ,  C12N2760/18032 ,  C12N2760/18071

摘要： The present invention relates to pharmaceutical compositions comprising Avian Paramyxovirus (APMV) for use in the treatment of a tumor in a mammal.

公开(公告)号：EP2571367B1

公开(公告)日：2016-01-13

申请号：EP11783849.0

申请日：2011-04-04

申请人： Weidong, Zhang ,  Lixian, Jiang ,  Calvin, Cao

发明人： Weidong, Zhang ,  Lixian, Jiang ,  Calvin, Cao

IPC分类号： C12N7/00 ,  A61K35/76

CPC分类号： A61K39/155 ,  A61K35/76 ,  A61K35/768 ,  C12N7/00 ,  C12N2760/18032 ,  C12N2760/18511 ,  C12N2760/18532 ,  C12N2760/18543

摘要： The invention discloses an engineered oncolytic respiratory syncytial virus (RSV), NS1 gene deficient RSV, and its usage to treat breast cancer by killing cancer cells with in vitro and in vivo evidences.

公开(公告)号：EP2252307A2

公开(公告)日：2010-11-24

申请号：EP09709608.5

申请日：2009-02-12

申请人： Bayer Schering Pharma Aktiengesellschaft

发明人： BEIER, Rudolf ,  PÜHLER, Florian

IPC分类号： A61K35/76

CPC分类号： A61K35/768 ,  A61K38/00 ,  C12N2760/18032

摘要： Paramyxovirus from the group APMV3, APMV4, APMV5, APMV6, APMV7, APMV8, APMV9, Mapueravirus and Fer-de-Lance virus are described, which can be used for the production of a medicament for the treatment of tumors. The virus has a selectivity to kill human tumor cells but not human normal differentiated and human normal proliferating cells at the same dose. By genetic engineering the virus can be modified in such a way that one or more genes are added or are replaced by the homologous genes of a related paramyxovirus. By that method the anti-tumor activity of the resulting chimeric virus is enhanced compared to the parental virus.

公开(公告)号：EP2579884B1

公开(公告)日：2014-06-04

申请号：EP11726102.4

申请日：2011-06-09

申请人： Intervet International B.V.

发明人： SCHRIER, Carla Christina ,  JAGT, Henricus Johannes Maria

IPC分类号： A61K35/76 ,  A61K39/42 ,  A61P35/00

CPC分类号： A61K35/76 ,  A61K35/768 ,  A61K45/06 ,  C12N2760/18032 ,  C12N2760/18071

摘要： The present invention relates to pharmaceutical compositions comprising Avian Paramyxovirus (APMV) for use in the treatment of a tumor in a mammal.

公开(公告)号：EP2571367A1

公开(公告)日：2013-03-27

申请号：EP11783849.0

申请日：2011-04-04

申请人： Zhang, Weidong ,  Jiang, Lixian ,  Cao, Calvin

发明人： Zhang, Weidong ,  Jiang, Lixian ,  Cao, Calvin

IPC分类号： A01N63/00 ,  A61K48/00

CPC分类号： A61K39/155 ,  A61K35/76 ,  A61K35/768 ,  C12N7/00 ,  C12N2760/18032 ,  C12N2760/18511 ,  C12N2760/18532 ,  C12N2760/18543

摘要： The invention discloses an engineered oncolytic respiratory syncytial virus (RSV), NS1 gene deficient RSV, and its usage to treat breast cancer by killing cancer cells with in vitro and in vivo evidences.