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    An infectious cDNA clone of North American porcine reproductive and respiratory syndrome (PRRS) virus and uses thereof
    5.
    发明公开
    An infectious cDNA clone of North American porcine reproductive and respiratory syndrome (PRRS) virus and uses thereof 有权
    在繁殖与呼吸综合征的感染性cDNA克隆造成北美猪流感病毒及其应用

    公开(公告)号：EP1627919A1

    公开(公告)日：2006-02-22

    申请号：EP05018141.1

    申请日：1999-11-25

    申请人： Pfizer Products Inc.

    发明人： Calvert, Jay Gregory ,  Welch, Siao-Kun Wan ,  Sheppard, Michael George

    IPC分类号： C12N15/40 ,  C12N15/86 ,  C12N5/10 ,  C07K14/08 ,  A61K39/12 ,  A61K39/295 ,  C12N7/04

    CPC分类号： C12N15/86 ,  A61K39/12 ,  A61K2039/525 ,  A61K2039/5254 ,  A61K2039/5256 ,  A61K2039/53 ,  A61K2039/552 ,  C07K14/005 ,  C12N7/00 ,  C12N2770/10021 ,  C12N2770/10034 ,  C12N2770/10043 ,  C12N2770/10061 ,  C12N2770/10062

    摘要： The invention provides isolated polynucleotide molecules, including plasmids; viral vectors; and transfected host cells that comprise a DNA sequence encoding an infectious RNA sequence encoding a North American PRRS virus; and also North American PRRS viruses encoded thereby. The invention further provides isolated infectious RNA molecules encoding a North American PRRS virus. The invention also provides isolated polynucleotide molecules, infectious RNA molecules, viral vectors, and transfected host cells encoding genetically-modified North American PRRS viruses; and genetically-modified North American PRRS viruses encoded thereby. The invention also provides vaccines comprising such plasmids, RNA molecules, viral vectors, and North American PRRS viruses, and methods of using these vaccines in swine and in other animals. Also provided are isolated polynucleotide molecules, viral vectors, and transfected host cells that comprise a nucleotide sequence encoding a peptide of a North American PRRS virus. These viral vectors and transfected host cell lines are useful in providing peptides to compensate for mutated peptide coding sequences of DNA sequences encoding genetically-modified North American PRRS viruses so that functional virions can be generated.

    摘要翻译： 本发明提供了分离的多核苷酸分子，包括质粒; 病毒载体; 而染的宿主细胞确实包含的DNA序列编码，在编码北美PRRS病毒之感染性RNA序列; 所以北美PRRS病毒所编码。 本发明提供编码北美PRRS病毒进一步分离的感染性RNA分子。 因此本发明提供了分离的多核苷酸分子，感染性RNA分子，病毒载体，和编码基因修饰型北美PRRS病毒的转染的宿主细胞; 和基因修饰型北美PRRS病毒所编码。 因此本发明提供了疫苗，其包括寻求质粒，RNA分子，病毒载体，和北美PRRS病毒，并使用在猪和其它动物中，这些疫苗的方法。 所以提供了分离的多核苷酸分子，病毒载体，并转染的宿主细胞并包含编码北美PRRS病毒的肽的核苷酸序列。 这些病毒载体和转染宿主细胞系是在提供的肽以补偿突变的肽编码的编码基因修饰型北美PRRS病毒作为确实可以产生功能病毒体的DNA序列的序列是有用的。

    Infectious cDNA clone of north american porcine reproductive and respiratory syndrome (PRRS) virus and uses thereof
    6.
    发明公开
    Infectious cDNA clone of north american porcine reproductive and respiratory syndrome (PRRS) virus and uses thereof 有权
    在繁殖与呼吸综合征的感染性cDNA克隆造成北美猪流感病毒及其应用

    公开(公告)号：EP1018557A2

    公开(公告)日：2000-07-12

    申请号：EP99309409.3

    申请日：1999-11-25

    申请人： Pfizer Products Inc.

    发明人： Calvert, Jay Gregory ,  Welch, Siao-Kun Wan ,  Sheppard, Michael George

    IPC分类号： C12N15/40 ,  C12N15/86 ,  C12N5/10 ,  C07K14/08 ,  A61K39/12 ,  A61K39/295

    CPC分类号： C12N15/86 ,  A61K39/12 ,  A61K2039/525 ,  A61K2039/5254 ,  A61K2039/5256 ,  A61K2039/53 ,  A61K2039/552 ,  C07K14/005 ,  C12N7/00 ,  C12N2770/10021 ,  C12N2770/10034 ,  C12N2770/10043 ,  C12N2770/10061 ,  C12N2770/10062

    摘要： The invention provides isolated polynucleotide molecules, including plasmids; viral vectors; and transfected host cells that comprise a DNA sequence encoding an infectious RNA sequence encoding a North American PRRS virus; and also North American PRRS viruses encoded thereby. The invention further provides isolated infectious RNA molecules encoding a North American PRRS virus. The invention also provides isolated polynucleotide molecules, infectious RNA molecules, viral vectors, and transfected host cells encoding genetically-modified North American PRRS viruses; and genetically-modified North American PRRS viruses encoded thereby. The invention also provides vaccines comprising such plasmids, RNA molecules, viral vectors, and North American PRRS viruses, and methods of using these vaccines in swine and in other animals. Also provided are isolated polynucleotide molecules, viral vectors, and transfected host cells that comprise a nucleotide sequence encoding a peptide of a North American PRRS virus. These viral vectors and transfected host cell lines are useful in providing peptides to compensate for mutated peptide coding sequences of DNA sequences encoding genetically-modified North American PRRS viruses so that functional virions can be generated.

    摘要翻译： 本发明提供了分离的多核苷酸分子，包括质粒; 病毒载体; 而染的宿主细胞确实包含的DNA序列编码，在编码北美PRRS病毒之感染性RNA序列; 所以北美PRRS病毒所编码。 本发明提供编码北美PRRS病毒进一步分离的感染性RNA分子。 因此本发明提供了分离的多核苷酸分子，感染性RNA分子，病毒载体，和编码基因修饰型北美PRRS病毒的转染的宿主细胞; 和基因修饰型北美PRRS病毒所编码。 因此本发明提供了疫苗，其包括寻求质粒，RNA分子，病毒载体，和北美PRRS病毒，并使用在猪和其它动物中，这些疫苗的方法。 所以提供了分离的多核苷酸分子，病毒载体，并转染的宿主细胞并包含编码北美PRRS病毒的肽的核苷酸序列。 这些病毒载体和转染宿主细胞系是在提供的肽以补偿突变的肽编码的编码基因修饰型北美PRRS病毒作为确实可以产生功能病毒体的DNA序列的序列是有用的。