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1.发明公开
公开(公告)号：EP4419541A1
公开(公告)日：2024-08-28
申请号：EP22884719.0
申请日：2022-10-21
发明人： DAHER, May , BASAR, Rafet , ACHARYA, Sunil , REZVANI, Katy , NUNEZ CORTES, Ana Karen , UPRETY, Nadima , ENSLEY, Emily
IPC分类号： C07K14/075 , C07K14/705 , A61K35/17 , C12N5/10 , C12N15/86 , A61K39/395 , C12N15/11
CPC分类号： C07K14/005 , C12N2710/1032220130101 , C12N2710/1033320130101 , C12N2710/2413320130101 , C12N2710/2412220130101 , C12N2770/2412220130101 , C12N2770/2413320130101 , C12N2770/2423320130101 , C12N2770/2422220130101 , C12N2730/1012220130101 , C12N2730/1013320130101 , A61P35/00 , C07K2319/0320130101 , C07K14/7051 , A61K39/4613 , A61K39/4631 , A61K39/464429 , A61K2239/3920230501 , A61K2239/5420230501 , C07K16/2875
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公开(公告)号：EP3870205B1
公开(公告)日：2024-07-31
申请号：EP19875861.7
申请日：2019-10-23
IPC分类号： A61K38/10 , C07K7/00 , C07K7/08 , C07K14/16 , C07K16/10 , C12Q1/68 , G01N33/53 , G01N33/543 , G01N33/68
CPC分类号： C07K16/1081 , C07K2317/5220130101 , C07K16/4283 , C07K14/005 , C12N2770/2412220130101 , G01N33/56983 , G01N33/54388 , G01N33/6854 , G01N2333/18520130101
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公开(公告)号：EP4387994A1
公开(公告)日：2024-06-26
申请号：EP22859443.8
申请日：2022-08-22
申请人： The Research Foundation for the State University of New York , The Government of the United States of America as represented by the Secretary of the Army
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公开(公告)号：EP4282483A3
公开(公告)日：2024-09-11
申请号：EP23196992.4
申请日：2015-07-23
申请人： Institut Pasteur , Université Paris-Saclay , Imperial College of Science, Technology and Medicine
发明人： DUQUERROY,, Stéphane , GUARDADO CALVO,, Pablo , SCREATON,, Gavin , ROUVINSKI,, Alexander , BARBA-SPAETH,, Giovanna , MONGKOLSAPAYA,, Juthathip , VANEY,, Marie-Christine , REY,, Felix Augusto
CPC分类号： C07K16/1081 , C07K2317/2120130101 , C07K2317/3320130101 , C07K2317/3420130101 , C12N2770/2412220130101 , C12N2770/2413420130101 , A61K39/12 , A61K2039/525820130101 , A61K2039/54520130101 , C07K14/1825 , A61P31/14 , Y02A50/30
摘要： A Dengue virus Envelope Dimer Epitope (EDE) wherein the EDE:
c) spans the polypeptides of a Dengue virus Envelope polypeptide dimer; and/or
d) is presented on a dimer of Envelope proteins; and/or
c) is formed from consecutive or non-consecutive residues of the envelope polypeptide dimer,
wherein the dimer is a homodimer or heterodimer of native and/or mutant envelope polypeptides, from any one or two of DENV-1, DENV-2, DENV-3 and DENV-4. The EDE may be a stabilized recombinant dengue virus envelope glycoprotein E ectodomain (sE) dimer, wherein the dimer is:
covalently stabilized with at least one disulphide inter-chain bond between the two sE monomers, and/or
covalently stabilized with at least one sulfhydryl-reactive crosslinker between the two sE monomers, and/or
covalently stabilized by linking the two sE monomers through modified sugars; and/or,
covalently stabilised by being formed as a single polypeptide chain, optionally with a linker region, optionally a Glycine Serine rich linker region, separating the sE sequences, and/or
non-covalently stabilized by substituting at least one amino acid residue in the amino acid sequence of at least one sE monomer with at least one bulky side chain amino acid, at the dimer interface or in domain 1 (D1) / domain 3 (D3) linker of each monomer.
A compound, for example an antibody or antibody fragment that can neutralise more than one Dengue virus serotype, for example an antibody that can bind to an EDE of the invention.-
公开(公告)号：EP3638304B1
公开(公告)日：2024-07-31
申请号：EP18818114.3
申请日：2018-06-11
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