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2.发明公开
公开(公告)号：EP4366770A1
公开(公告)日：2024-05-15
申请号：EP22838562.1
申请日：2022-07-06
IPC分类号： A61K39/29 , A61P31/14 , A61P37/04 , C07K16/10 , A61K31/7088 , C12N7/00 , G01N33/576
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公开(公告)号：EP4430061A1
公开(公告)日：2024-09-18
申请号：EP22891260.6
申请日：2022-11-14
申请人： University Health Network , The Governing Council of The University of Toronto , University of Liverpool , Centers for Disease Control and Prevention , The United States of America, as represented by the Secretary, Department of Health and Human Services , Campo, David S. , Urbanowicz, Richard A. , Abouhaidar, Mounir G.
发明人： MOSA, Alexander I. , FELD, Jordan J. , CAMPO, David S. , URBANOWICZ, Richard A. , ABOUHAIDAR, Mounir G.
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公开(公告)号：EP4400510A2
公开(公告)日：2024-07-17
申请号：EP24158688.2
申请日：2007-07-30
发明人： Weiner, David B. , Yan, Jian
IPC分类号： C07K14/00
CPC分类号： C12N2740/1612220130101 , C12N2740/1613420130101 , C12N2740/1622220130101 , C12N2740/1623420130101 , C12N2740/1632220130101 , C12N2740/1633420130101 , A61K39/12 , A61K2039/52320130101 , A61K2039/5320130101 , C12N2710/2003420130101 , C12N2760/1613420130101 , C12N2770/2423420130101 , A61K38/00 , A61K2039/5420130101 , A61K2039/5553820130101 , A61K2039/58520130101 , C07K14/005 , A61P15/00 , A61P31/12 , A61P31/14 , A61P31/16 , A61P31/18 , A61P31/20 , A61P35/00 , A61P37/04 , A61K39/001157 , A61K39/00 , A61K39/4611 , A61K39/0011 , A61K39/464838
摘要： Improved anti-HIV immunogens and nucleic acid molecules that encode them are disclosed. Immunogens disclosed include those having consensus sequences for HIV Subtype A Envelope protein, those having consensus sequences for HIV Subtype B Envelope protein, those having consensus sequences for HIV Subtype C Envelope protein, those having consensus sequences for HIV Subtype D Envelope protein, those having consensus sequences for HIV Subtype B consensus Nef-Rev protein, and those having consensus sequences for HIV Gag protein subtypes A, B, C and D. Improved anti-HPV immunogens and nucleic acid molecules that encode them; improved anti-HCV immunogens and nucleic acid molecules that encode them; improved hTERT immunogens and nucleic acid molecules that encode them; and improved anti-Influenza immunogens and nucleic acid molecules that encode them are disclosed. Pharmaceutical composition, recombinant vaccines comprising and live attenuated pathogens are disclosed as well methods of inducing an immune response in an individual against HIV, HPV, HCV, hTERT and Influenza are disclosed.
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公开(公告)号：EP4410970A2
公开(公告)日：2024-08-07
申请号：EP24175721.0
申请日：2019-02-08
申请人： Hvidovre Hospital
发明人： BUKH, Jens , VAN PHAM, Long , RAMIREZ ALMELDA, Santseharay , GOTTWEIN, Judith Margarete , LI, Yi-Ping , PEDERSEN, Jannie
IPC分类号： C12N7/00
CPC分类号： A61K39/12 , C12N7/00 , C12N2770/2422120130101 , C12N2770/2423420130101 , C12N2770/2425120130101 , A61P31/20
摘要： The present invention relates to nucleic acid sequences that encode hepatitis C viruses (HCV) of genotype 6a that are useful in the fundamental research of HCV as well as in the search of antivirals and vaccines against HCV. In particular, the present invention relates to nucleic acid sequences that comprises HCVs, which are capable of expressing said virus when transfected into cells and are capable of replication or infectivity in cultured cells.
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公开(公告)号：EP4380606A1
公开(公告)日：2024-06-12
申请号：EP22851488.1
申请日：2022-08-04
发明人： TORRESI, Joseph
IPC分类号： A61K39/00 , A61K39/12 , A61K39/145 , A61K39/215 , A61K39/29 , A61P31/12 , C12N7/00 , C07K14/005 , C07K14/18
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公开(公告)号：EP3749755B1
公开(公告)日：2024-06-12
申请号：EP19708769.5
申请日：2019-02-08
IPC分类号： C12N7/00
CPC分类号： A61K39/12 , C12N7/00 , C12N2770/2422120130101 , C12N2770/2423420130101 , C12N2770/2425120130101 , A61P31/20
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