公开(公告)号：EP4368202A3

公开(公告)日：2024-08-21

申请号：EP23219605.5

申请日：2008-03-31

申请人： The Research Foundation for The State University of New York

发明人： WIMMER, Eckard ,  SKIENA, Steve ,  MUELLER, Steffen ,  FUTCHER, Bruce ,  PAPAMICHAIL, Dimitris ,  COLEMAN, John Robert ,  CELLO, Jeronimo

IPC分类号： A61K39/13 ,  A61K39/12

CPC分类号： A61K2039/525420130101 ,  C12N2720/1236120130101 ,  C12N2740/1506120130101 ,  C12N2760/1606120130101 ,  C12N2770/2006120130101 ,  C12N2770/2416120130101 ,  C12N2770/3206120130101 ,  C12N2770/3266120130101 ,  C12N2770/3276120130101 ,  A61K39/12 ,  C12N7/00 ,  A61P31/12 ,  A61P31/14 ,  A61P31/16 ,  A61P31/18 ,  A61P31/20 ,  A61P31/22 ,  A61P37/04 ,  Y02A50/30

摘要： This invention provides an attenuated virus which comprises a modified viral genome containing nucleotide substitutions engineered in multiple locations in the genome, wherein the substitutions introduce synonymous deoptimized codons into the genome. The instant attenuated virus may be used in a vaccine composition for inducing a protective immune response in a subject. The invention also provides a method of synthesizing the instant attenuated virus. Further, this invention further provides a method for preventing a subject from becoming afflicted with a virus-associated disease comprising administering to the subject a prophylactically effective dose of a vaccine composition comprising the instant attenuated virus.

公开(公告)号：EP4368202A2

公开(公告)日：2024-05-15

申请号：EP23219605.5

申请日：2008-03-31

申请人： The Research Foundation for The State University of New York

发明人： WIMMER, Eckard ,  SKIENA, Steve ,  MUELLER, Steffen ,  FUTCHER, Bruce ,  PAPAMICHAIL, Dimitris ,  COLEMAN, John Robert ,  CELLO, Jeronimo

IPC分类号： A61K39/12

CPC分类号： A61K2039/525420130101 ,  C12N2720/1236120130101 ,  C12N2740/1506120130101 ,  C12N2760/1606120130101 ,  C12N2770/2006120130101 ,  C12N2770/2416120130101 ,  C12N2770/3206120130101 ,  C12N2770/3266120130101 ,  C12N2770/3276120130101 ,  A61K39/12 ,  C12N7/00 ,  A61P31/12 ,  A61P31/14 ,  A61P31/16 ,  A61P31/18 ,  A61P31/20 ,  A61P31/22 ,  A61P37/04 ,  Y02A50/30

摘要： This invention provides an attenuated virus which comprises a modified viral genome containing nucleotide substitutions engineered in multiple locations in the genome, wherein the substitutions introduce synonymous deoptimized codons into the genome. The instant attenuated virus may be used in a vaccine composition for inducing a protective immune response in a subject. The invention also provides a method of synthesizing the instant attenuated virus. Further, this invention further provides a method for preventing a subject from becoming afflicted with a virus-associated disease comprising administering to the subject a prophylactically effective dose of a vaccine composition comprising the instant attenuated virus.