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1.发明公开Isopenicillin N derivatives, their preparation and use and intermediates therefor 失效异青霉素N-衍生物，它们的制造和使用以及它们的中间体。
公开(公告)号：EP0174129A1
公开(公告)日：1986-03-12
申请号：EP85305911.1
申请日：1985-08-20
发明人： Baldwin, Jack Edward
IPC分类号： C07D499/48 , C12P37/00 , A61K31/43 , C07K5/06
CPC分类号： C12N9/93 , A61K38/00 , C07C59/315 , C07C271/22 , C07D499/00 , C07K5/0215 , C12P37/00 , C12R1/465 , C12R1/75 , C12R1/82 , Y02A50/473 , Y02A50/481
摘要： A compound of formula I or a physiologically acceptable salt thereof
wherein X represents sulphur or methylene, R, represents hydrogen, amino or an acylated or carbamylated amino group, R 2 represents hydrogen or an alkyl group and R 3 represents an alkoxy group; preparation thereof by subjecting a tripeptide of formula III,
to the action of the enzyme isopenicillin N synthethase, and the tripeptide of formula III.-
公开(公告)号：EP0209363B1
公开(公告)日：1992-05-06
申请号：EP86305447.4
申请日：1986-07-15
申请人： Antibioticos, S.A.
发明人： Luengo, Jose Maria c/o Antibioticos S.A. , Lopez-Nieto, M. J. c/o Antibioticos S.A. , Salto, Francisco c/o Antibioticos S.A.
CPC分类号： C07K5/0606 , C12P37/00 , C12R1/465 , C12R1/75 , C12R1/82
摘要： Penicillin G and analogous penicillins with arylacylamido side chains can be produced by the action of cyclase on PCV, POCV, or appropriate analogue thereof.
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公开(公告)号：EP0244195A1
公开(公告)日：1987-11-04
申请号：EP87303725.3
申请日：1987-04-28
发明人： Baldwin, Jack Edward
IPC分类号： C12P37/00 , C07D499/44 , C07D499/42
CPC分类号： C07D499/00 , C12P37/00 , C12R1/75
摘要： 6β-(L-α-Aminoadipoyl)-2α-vinyl-2β-methylpenam-3-carboxylic acid is provided in an enzymatic process converting δ-(L-α-aminoadipoyl)-L-cysteinyl-D-γ,δ-didehydroisoleucine with isopenicillin N synthetase. The 2α-vinylpenam product is converted by known methods to the 6β-amino-2α-vinyl-2β-methylpenam-3-carboxylic acid nucleus and the latter is N-acylated to provide corresponding 6β-acylaminopenams.
摘要翻译： 在酶促过程中提供6β-（L-α-氨基己二酰）-2α-乙烯基-2β-甲基戊烷-3-羧酸，将δ-（L-α-氨基己二酰）-L-半胱氨酰-D-γ，δ-双脱氢异亮氨酸 与异青霉素N合成酶。 通过已知方法将2α-乙烯基铁蛋白产物转化为6β-氨基-2α-乙烯基-2β-甲基戊-3-羧酸核，后者N-酰化以提供相应的6β-酰氨基苯丙氨酸。
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公开(公告)号：EP0209363A3
公开(公告)日：1988-03-09
申请号：EP86305447
申请日：1986-07-15
申请人： Antibioticos, S.A.
发明人： Luengo, Jose Maria c/o Antibioticos S.A. , Lopez-Nieto, M. J. c/o Antibioticos S.A. , Salto, Francisco c/o Antibioticos S.A.
IPC分类号： C07K05/06 , C12P37/00 , C12R01/75 , C12R01/82 , C12R01/465
CPC分类号： C07K5/0606 , C12P37/00 , C12R1/465 , C12R1/75 , C12R1/82
摘要： Penicillin G and analogous penicillins with arylacylamido side chains can be produced by the action of cyclase on PCV, POCV, or appropriate analogue thereof.
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公开(公告)号：EP0224390A1
公开(公告)日：1987-06-03
申请号：EP86309153.4
申请日：1986-11-24
发明人： Baldwin, Jack Edward
IPC分类号： C07D499/42 , C07D499/12
CPC分类号： C12P37/00 , C07D499/00 , C12R1/75
摘要： A compound of Formula II:
wherein R is hydrogen or an alkyl group and R' is an alkoxy group, and salts and esters thereof.-
6.发明公开Heteropeptides, intermediates in the biosynthesis of penicillins 失效异肽，Zwischenprodukte zur Biosynthese von Penizillinen。
公开(公告)号：EP0209363A2
公开(公告)日：1987-01-21
申请号：EP86305447.4
申请日：1986-07-15
申请人： Antibioticos, S.A.
发明人： Luengo, Jose Maria c/o Antibioticos S.A. , Lopez-Nieto, M. J. c/o Antibioticos S.A. , Salto, Francisco c/o Antibioticos S.A.
CPC分类号： C07K5/0606 , C12P37/00 , C12R1/465 , C12R1/75 , C12R1/82
摘要： Penicillin G and analogous penicillins with arylacylamido side chains can be produced by the action of cyclase on PCV, POCV, or appropriate analogue thereof.
摘要翻译： 青霉素G和类似的具有芳基酰氨基酰氨基侧链的青霉素可以通过环化酶对PCV，POCV或其合适的类似物的作用产生。
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