公开(公告)号：EP2638381B1

公开(公告)日：2018-09-05

申请号：EP11785554.4

申请日：2011-11-09

Applicant: Roche Diagnostics Hematology, Inc.

Inventor： LAPEN, Daniel ,  ZAHNISER, David ,  LICARI, Mark ,  MCKEEN, Brian J. ,  YEATON, Eric D. ,  POOLE, Dennis

IPC: G01N1/31 ,  G01N35/00 ,  G01N35/10

CPC classification number: G01N1/312 ,  G01N1/30 ,  G01N35/00029 ,  G01N35/0099 ,  G01N2035/00079 ,  G01N2035/00138 ,  G01N2035/00524 ,  G01N2035/1037

Abstract: The systems and methods disclosed herein permit automated preparation of biological specimens for examination. The disclosed systems and methods provide fast, efficient, and highly uniform specimen processing using minimal quantities of fluids. The methods include at least a fixing phase for fixing a biological specimen to a substrate such as a microscope slide, a staining phase for staining the specimen, and a rinsing phase for rinsing the specimen. One or more of the fixing, staining, and rinsing phases include one or more agitation cycles for distributing reagents evenly and uniformly across the specimen. The systems can be implemented as a standalone device or as a component in a larger system for preparing and examining biological specimens.

公开(公告)号：EP3175246B1

公开(公告)日：2018-05-23

申请号：EP15767266.8

申请日：2015-07-29

Applicant: Diapath S.p.A.

Inventor： LIMONTA, Enzo ,  MANENTI, Giorgio ,  RIZZATO, Fabio ,  BERGAMINI, Vladimiro

IPC: G01N35/00 ,  C12M1/28 ,  C12M1/26 ,  G02B21/34

CPC classification number: G01N35/00029 ,  G01N2035/00039 ,  G01N2035/00089 ,  G01N2035/00138 ,  G01N2035/00861 ,  G02B21/34

Abstract: A device (1) for handling slides (2), and/or cassettes (3), for specimens of biological material is described and comprises at least one supporting container (10) in which a plurality of cassettes or slides are inserted and supported in at least one rest position in which the cassettes, or slides, are arranged in succession, preferably in a plurality of spaces (S). The container (10) comprises guide means (15) for the insertion and support, in its inside, of at least one slide or cassette. The device further comprises displacing means (8) to displace at least one slide (2), or at least one cassette (3), from the rest position towards at least one operative position, while holding the slide, or cassette, inside the container (10). A method for handling slides and/or cassettes is further described.

公开(公告)号：EP3199936A4

公开(公告)日：2018-05-02

申请号：EP15845267

申请日：2015-09-18

Applicant: NICHIREI BIOSCIENCES INC

Inventor： KASAMATSU TOSHIYUKI ,  HORIKOSHI NOBORU

IPC: G01N1/30 ,  G01N1/28 ,  G01N1/31 ,  G01N33/48 ,  G01N35/00

CPC classification number: G01N1/312 ,  G01N1/28 ,  G01N1/30 ,  G01N33/48 ,  G01N35/00029 ,  G01N35/00722 ,  G01N35/0095 ,  G01N2035/00138 ,  G01N2035/00356

Abstract: Provided are an automatic tissue staining device and an automatic tissue staining method capable of advancing treatments according to precise treatment times without a hitch. The automatic tissue staining device includes a supply head that supplies a treatment fluid, a horizontal direction movement unit that moves the supply head in a horizontal direction, and a holding unit that holds a plurality of glass slides on which samples are set. The automatic tissue staining device further includes a control unit that judges occupancy status of the horizontal direction movement unit in a condition that one or more of the glass slides are situated in a first region prior to supplying the treatment fluid from the supply head to one or more samples on the one or more glass slides situated in the first region, suspends a start of a treatment for the samples on the one or more glass slides situated in the first region when the horizontal direction movement unit is occupied, and permits the treatment for the samples on the one or more glass slides situated in the first region when the horizontal direction movement unit is not occupied.

公开(公告)号：EP3298381A1

公开(公告)日：2018-03-28

申请号：EP16724342.7

申请日：2016-05-13

Applicant: Ventana Medical Systems, Inc.

Inventor： GROLL, Henning ,  KERNAG, Casey A. ,  WEIDNER, Charles H. ,  DURRANT, Edward E. ,  WEIR, Kenneth

IPC: G01N1/30 ,  B01L3/00 ,  G01N1/31 ,  G01N35/10 ,  G01N35/00

CPC classification number: G01N1/30 ,  C09B67/0014 ,  C09B67/0017 ,  G01N1/312 ,  G01N35/1002 ,  G01N35/1004 ,  G01N2001/302 ,  G01N2035/00138 ,  G01N2035/00277

Abstract: Methods and compositions for removing precipitates or reducing the formation of precipitates generated in hematoxylin solutions. The methods and compositions feature cleaning solutions that feature chemical compounds that initiate processes including but not limited to acidification of the waste solution, chelation of metal ions in the waste solution, reduction reactions, oxidation reactions, and metal salt addition reactions.

公开(公告)号：EP3280543A1

公开(公告)日：2018-02-14

申请号：EP16777179.9

申请日：2016-04-06

Applicant: Nanocytomics LLC ,  Northwestern University

Inventor： CZARNECKI, Jarema ,  DERBAS, Justin ,  ROZHOK, Sergey ,  SUBRAMANIAN, Hariharan ,  VISWANATHAN, Parvathi

IPC: B05D5/00

CPC classification number: G01N35/00029 ,  G01N1/2813 ,  G01N1/312 ,  G01N35/00871 ,  G01N35/1011 ,  G01N2001/317 ,  G01N2035/00138 ,  G01N2035/00168 ,  G01N2035/00881

Abstract: Systems and methods that enable automated spray deposition of biological specimens carried on microscope slides are described herein. Aspects of the technology are directed, for example, to automated specimen deposition systems and methods of generating high-quality, reproducible specimen-bearing microscope slides in automated processing systems.

公开(公告)号：EP3276328A2

公开(公告)日：2018-01-31

申请号：EP17183752.9

申请日：2017-07-28

Applicant: SYSMEX CORPORATION

Inventor： Nakajima, Takayuki ,  Yamaguchi, Katsuaki ,  Oda, Tetsuya ,  Shinabe, Seiya ,  Yamasaki, Mitsuo ,  Hidetaka, Hayama

IPC: G01N1/31 ,  G01N35/00

CPC classification number: G01N35/00871 ,  G01N1/2813 ,  G01N1/312 ,  G01N15/1468 ,  G01N15/1475 ,  G01N33/49 ,  G01N35/00732 ,  G01N35/0099 ,  G01N35/026 ,  G01N2015/1472 ,  G01N2035/00138 ,  G01N2035/00891 ,  G01N2035/0413 ,  G06K9/00134

Abstract: A smear transporting apparatus transports a smear slide on which a sample is smeared to a smear-image capture apparatus. The smear transporting apparatus includes a smear-container transport part that transports a first smear container accommodating smear slides to a smear pickup position; a smear transfer part that picks a smear slide whose image is to be captured by the smear-image capture apparatus from the first smear container transported to the smear pickup position, transfers the smear slide to the smear-image capture apparatus, and places the smear slide whose image has been captured by the smear-image capture apparatus in a second smear container different from the first smear container; and a storage that stores the first smear container the second smear container.

Abstract translation: 涂抹传输设备将其上涂抹有样本的涂片载玻片传输至涂片图像捕获设备。 所述涂抹传输装置包括：涂抹容器传送部分，用于传送容纳涂片的第一涂片容器在涂抹位置滑动; 涂抹转印部分，其将图像由涂片图像采集设备从被输送到涂抹标记拾取位置的第一涂片容器中采集，并将涂片载片转移到涂片图像采集设备，并将涂片 其图像已被所述涂片图像捕获设备捕获到的滑块位于与所述第一涂片容器不同的第二涂片容器中; 以及将第一涂片容器存储在第二涂片容器中的存储器。

公开(公告)号：EP3175246A1

公开(公告)日：2017-06-07

申请号：EP15767266.8

申请日：2015-07-29

Applicant: Diapath S.p.A.

Inventor： LIMONTA, Enzo ,  MANENTI, Giorgio ,  RIZZATO, Fabio ,  BERGAMINI, Vladimiro

IPC: G01N35/00 ,  C12M1/28 ,  C12M1/26 ,  G02B21/34

CPC classification number: G01N35/00029 ,  G01N2035/00039 ,  G01N2035/00089 ,  G01N2035/00138 ,  G01N2035/00861 ,  G02B21/34

Abstract: A device (1) for handling slides (2), and/or cassettes (3), for specimens of biological material is described and comprises at least one supporting container (10) in which a plurality of cassettes or slides are inserted and supported in at least one rest position in which the cassettes, or slides, are arranged in succession, preferably in a plurality of spaces (S). The container (10) comprises guide means (15) for the insertion and support, in its inside, of at least one slide or cassette. The device further comprises displacing means (8) to displace at least one slide (2), or at least one cassette (3), from the rest position towards at least one operative position, while holding the slide, or cassette, inside the container (10). A method for handling slides and/or cassettes is further described.

Abstract translation: 一种用于处理载片装置（1）（2），和/或盒（3），用于生物材料的样品被描述，并且包括至少一个支撑在其中盒或幻灯片的多元性被插入并支承在容器（10） 至少一个静止位置，其中盒，或幻灯片，被连续布置，优选地在空间有多个（S）。 所述容器（10）包括用于插入和支承导向装置（15），在其内部，所述至少一个滑块或盒。 该装置还包括移位装置（8）以置换至少一个滑块（2），或至少一个盒（3），从朝向至少一个工作位置的静止位置，同时保持所述滑动，或盒中，在容器内部 （10）。 一种用于处理载片和/或盒方法进行进一步描述。

公开(公告)号：EP3172552A1

公开(公告)日：2017-05-31

申请号：EP15824655.3

申请日：2015-04-08

Applicant: XMD, LLC

Inventor： RITTERBUSH, Stephen ,  OEU, Ting Pau

IPC: G01N21/00

CPC classification number: G01N1/2813 ,  G01N1/312 ,  G01N35/00029 ,  G01N35/025 ,  G01N2001/2833 ,  G01N2035/00138 ,  Y10T436/25375

Abstract: Methods, devices, and systems for integrating extraction and purification of bio-sample regions and materials with patient analysis, diagnosis, follow up, and treatment. The invention provides a means to insert disclosed substrates, cartridges, and cartridge-processing instrument or instruments into a standard clinic or pathology laboratory workflow. Specifically, we disclose methods, devices, and systems for inserting standard pathology slides into disclosed cartridges and cartridge-processing instruments, either manually, semi-automatically, automatically, or by robotic means.

Abstract translation: 方法，装置和系统，用于与患者的分析，诊断，随访，以及治疗生物样本区域和材料的INTEGRA婷提取和纯化。 本发明提供一种手段来插入光盘基板游离缺失，药筒，和盒处理仪器或工具插入一个标准的诊所或病理实验室的工作流。 具体而言，我们公开的方法，装置，和用于插入标准病理学滑入游离缺失盘盒和盒处理仪器，可以手动地，半自动地，自动地，或由自动装置系统。

公开(公告)号：EP3161449A1

公开(公告)日：2017-05-03

申请号：EP15733423.6

申请日：2015-06-26

Applicant: Ventana Medical Systems, Inc.

Inventor： KETTERER, Matthew ,  SCHURIG, Michael ,  WILLEMS, John ,  DURRANT, Timothy ,  QUIJADA, Jorge Nicolas

IPC: G01N1/31 ,  G01N35/00

CPC classification number: G01N1/312 ,  G01N35/00029 ,  G01N35/0092 ,  G01N2001/315 ,  G01N2035/00059 ,  G01N2035/00138

Abstract: The disclosure presents systems and methods for processing a specimen slide using a specimen processing system. Specimen slides may sequentially be ejected from a slide carrier towards a label reader to determine an appropriate processing protocol for the slides. A cracking element may be engaged with the slide carrier prior to ejecting the slide, in order to break or “crack” any residual adhesive bond between edges of a slide and walls of the carrier. The specimen slides may be horizontally aligned and resting on a corresponding plurality of flat shelves, enabling even spacing via gravitational forces. The slides are therefore evenly spaced, enabling damage-free ejection of slides, and proper positioning for additional operations including scanning, viewing, heating, washing, and other processing. The label reader may process scanned information from the label of the slide to determine one or more attributes of the slide, and to generate an order or sequence of operations to be thereafter performed on the slide.

Abstract translation: 本公开提出了使用样本处理系统处理样本载玻片的系统和方法。 标本载玻片可以顺序地从载玻片载体朝标签读取器排出以确定载玻片的适当处理方案。 在排出载玻片之前，可以将裂化元件与载玻片载体接合，以便破坏或“裂化”载玻片的边缘和载体的壁之间的任何残余粘合剂结合。 样本载玻片可以水平对齐并且搁置在相应的多个平坦搁架上，通过重力实现均匀间隔。 因此，载玻片间隔均匀，可以无损伤地排出载玻片，并可正确定位以进行其他操作，包括扫描，观察，加热，清洗和其他处理。 标签阅读器可处理来自载玻片标签的扫描信息以确定载玻片的一个或多个属性，并产生此后在载玻片上执行的操作顺序或顺序。

公开(公告)号：EP3161448A1

公开(公告)日：2017-05-03

申请号：EP15731342.0

申请日：2015-06-25

Applicant: Ventana Medical Systems, Inc.

Inventor： KETTERER, Matthew ,  JAMES, Benjamin Arthur ,  WILLEMS, John Douglas ,  HARRISON, Joshua David Kenneth ,  DURRANT, Timothy James

IPC: G01N1/31 ,  G01N35/00

CPC classification number: G01N35/00029 ,  G01N1/312 ,  G01N35/0092 ,  G01N35/0099 ,  G01N2035/00059 ,  G01N2035/00138

Abstract: Systems and methods that enable automated processing of specimens carried on microscope slides are described herein. In some embodiments, the system can include, for example, a slide ejector assembly having a slide staging device configured to receive a slide and an over-travel inhibitor that includes a first vacuum port positioned to draw a first vacuum between the slide and a standby platform as the slide is moved across at least a portion of the standby platform. The over-travel inhibitor includes a first sensor for detecting a presence of the slide on the standby platform. The system can also include a transfer assembly to transport slides away from the slide ejector assembly. The transfer assembly can include a floating transfer head having a vacuum port for drawing a partial vacuum for holding the slide.

Abstract translation: 系统和方法那样使携带的显微镜载玻片上的标本中描述的自动化处理。 在一些实施例中，该系统可以包括，例如，一个滑动喷射器组件，其具有被配置为接收关于超行程抑制剂的滑动件和滑动做了滑动分段设备包括定位成绘制和备用之间的第一真空的第一真空端口 平台为滑横跨备用平台的至少一部分上移动。 超程抑制剂包括用于备用平台上检测滑动件的存在的第一传感器。 因此，该系统可以包括一个转印组件运送载玻片从载玻片喷射器组件的路程。 传送组件可包括具有一个真空口用于绘制部分真空用于保持滑动浮动转印头。