公开(公告)号：EP2569451A4

公开(公告)日：2013-09-11

申请号：EP11781368

申请日：2011-05-13

申请人： RULES BASED MEDICINE INC

发明人： O'BRYANT SIDNEY E ,  BARBER ROBERT CLINTON ,  DIAZ-ARRASTIA RAMON ,  XIAO GUANGHUA ,  ADAMS PIERRIE MILTON ,  REISCH JOAN SNAVELY ,  DOODY RACHELLE SMITH ,  FAIRCHILD THOMAS JOHN ,  MCDADE RALPH L ,  LABRIE SAMUEL T

IPC分类号： C12Q1/68 ,  G01N33/68

CPC分类号： G01N33/54306 ,  C12Q1/6883 ,  C12Q2600/156 ,  G01N33/6896

公开(公告)号：EP2462447A1

公开(公告)日：2012-06-13

申请号：EP10807276.0

申请日：2010-08-06

申请人： Rules-Based Medicine, Inc.

发明人： SPAIN, Michael, D. ,  MAPES, James, P. ,  LABRIE, Samuel, T. ,  MCDADE, Ralph, L. ,  EISINGER, Dominic ,  BALLARD, Karri, L.

IPC分类号： G01N33/566 ,  G01N33/53

CPC分类号： G01N33/6893 ,  G01N33/5302 ,  G01N33/566 ,  G01N2333/47 ,  G01N2333/4703 ,  G01N2333/4706 ,  G01N2333/4725 ,  G01N2333/4727 ,  G01N2333/475 ,  G01N2333/52 ,  G01N2333/70503 ,  G01N2333/70539 ,  G01N2333/765 ,  G01N2333/775 ,  G01N2333/8139 ,  G01N2333/8146 ,  G01N2333/82 ,  G01N2333/91177 ,  G01N2800/34 ,  G01N2800/347 ,  G01N2800/52 ,  G01N2800/56 ,  G01N2800/60 ,  Y10T436/147777

摘要： Methods and devices for diagnosing, monitoring, or determining kidney transplant rejection or an associated disorder in a mammal are described. In particular, methods and devices for diagnosing, monitoring, or determining kidney transplant rejection or an associated disorder using measured concentrations of a combination of three or more analytes in a test sample taken from the mammal are described.

公开(公告)号：EP2462438A1

公开(公告)日：2012-06-13

申请号：EP10807278.6

申请日：2010-08-06

申请人： Rules-Based Medicine, Inc.

发明人： SPAIN, Michael ,  MAPES, James, P. ,  LABRIE, Samuel ,  MCDADE, Ralph ,  EISINGER, Dominic ,  BALLARD, Karri ,  SALOMON, Daniel ,  ABECASSIS, Michael

IPC分类号： G01N33/48

CPC分类号： G01N33/6893 ,  G01N33/5302 ,  G01N33/566 ,  G01N2333/47 ,  G01N2333/4703 ,  G01N2333/4706 ,  G01N2333/4725 ,  G01N2333/4727 ,  G01N2333/475 ,  G01N2333/52 ,  G01N2333/70503 ,  G01N2333/70539 ,  G01N2333/765 ,  G01N2333/775 ,  G01N2333/8139 ,  G01N2333/8146 ,  G01N2333/82 ,  G01N2333/91177 ,  G01N2800/34 ,  G01N2800/347 ,  G01N2800/52 ,  G01N2800/56 ,  G01N2800/60 ,  Y10T436/147777

摘要： Methods and devices for diagnosing, monitoring, or determining kidney transplant rejection or an associated disorder in a mammal are described. In particular, methods and devices for diagnosing, monitoring, or determining kidney transplant rejection or an associated disorder using measured concentrations of a combination of three or more analytes in a test sample taken from the mammal are described.

公开(公告)号：EP2462437A1

公开(公告)日：2012-06-13

申请号：EP10807277.8

申请日：2010-08-06

申请人： Rules-Based Medicine, Inc.

发明人： SPAIN, Michael, D. ,  MAPES, James, P. ,  LABRIE, Samuel, T. ,  MCDADE, Ralph, L. ,  EISINGER, Dominic ,  BALLARD, Karri, L.

IPC分类号： G01N33/48

CPC分类号： G01N33/6893 ,  G01N33/5302 ,  G01N33/566 ,  G01N2333/47 ,  G01N2333/4703 ,  G01N2333/4706 ,  G01N2333/4725 ,  G01N2333/4727 ,  G01N2333/475 ,  G01N2333/52 ,  G01N2333/70503 ,  G01N2333/70539 ,  G01N2333/765 ,  G01N2333/775 ,  G01N2333/8139 ,  G01N2333/8146 ,  G01N2333/82 ,  G01N2333/91177 ,  G01N2800/34 ,  G01N2800/347 ,  G01N2800/52 ,  G01N2800/56 ,  G01N2800/60 ,  Y10T436/147777

摘要： Methods and devices for diagnosing, monitoring, or determining kidney transplant rejection or an associated disorder in a mammal are described. In particular, methods and devices for diagnosing, monitoring, or determining kidney transplant rejection or an associated disorder using measured concentrations of a combination of three or more analytes in a test sample taken from the mammal are described.

公开(公告)号：EP2569451A1

公开(公告)日：2013-03-20

申请号：EP11781368.3

申请日：2011-05-13

申请人： Rules-Based Medicine, Inc.

发明人： O'BRYANT, Sidney E. ,  BARBER, Robert Clinton ,  DIAZ-ARRASTIA, Ramon ,  XIAO, Guanghua ,  ADAMS, Pierrie Milton ,  REISCH, Joan Snavely ,  DOODY, Rachelle Smith ,  FAIRCHILD, Thomas John ,  MCDADE, Ralph L. ,  LABRIE, Samuel T.

IPC分类号： C12Q1/68

CPC分类号： G01N33/54306 ,  C12Q1/6883 ,  C12Q2600/156 ,  G01N33/6896

摘要： Methods and devices for predicting, diagnosing, monitoring, or determining Alzheimer's disease in a human are described. In particular, methods and devices for predicting diagnosing, monitoring, or determining AD using measured concentrations of a combination of three or more analytes in a test sample taken from the human are described.

公开(公告)号：EP2462437A4

公开(公告)日：2013-01-30

申请号：EP10807277

申请日：2010-08-06

申请人： RULES BASED MEDICINE INC

发明人： SPAIN MICHAEL D ,  MAPES JAMES P ,  LABRIE SAMUEL T ,  MCDADE RALPH L ,  EISINGER DOMINIC ,  BALLARD KARRI L

IPC分类号： G01N33/48 ,  G01N33/53 ,  G01N33/68

CPC分类号： G01N33/6893 ,  G01N33/5302 ,  G01N33/566 ,  G01N2333/47 ,  G01N2333/4703 ,  G01N2333/4706 ,  G01N2333/4725 ,  G01N2333/4727 ,  G01N2333/475 ,  G01N2333/52 ,  G01N2333/70503 ,  G01N2333/70539 ,  G01N2333/765 ,  G01N2333/775 ,  G01N2333/8139 ,  G01N2333/8146 ,  G01N2333/82 ,  G01N2333/91177 ,  G01N2800/34 ,  G01N2800/347 ,  G01N2800/52 ,  G01N2800/56 ,  G01N2800/60 ,  Y10T436/147777

摘要： Methods and devices for diagnosing, monitoring, or determining kidney transplant rejection or an associated disorder in a mammal are described. In particular, methods and devices for diagnosing, monitoring, or determining kidney transplant rejection or an associated disorder using measured concentrations of a combination of three or more analytes in a test sample taken from the mammal are described.

公开(公告)号：EP2462436A4

公开(公告)日：2013-01-30

申请号：EP10807271

申请日：2010-08-06

申请人： RULES BASED MEDICINE INC

发明人： SPAIN MICHAEL D ,  MAPES JAMES P ,  LABRIE SAMUEL ,  MCDADE RALPH ,  EISINGER DOMINIC ,  BALLARD KARRI

IPC分类号： G01N33/48 ,  G01N33/53 ,  G01N33/68

CPC分类号： G01N33/6893 ,  G01N33/5302 ,  G01N33/566 ,  G01N2333/47 ,  G01N2333/4703 ,  G01N2333/4706 ,  G01N2333/4725 ,  G01N2333/4727 ,  G01N2333/475 ,  G01N2333/52 ,  G01N2333/70503 ,  G01N2333/70539 ,  G01N2333/765 ,  G01N2333/775 ,  G01N2333/8139 ,  G01N2333/8146 ,  G01N2333/82 ,  G01N2333/91177 ,  G01N2800/34 ,  G01N2800/347 ,  G01N2800/52 ,  G01N2800/56 ,  G01N2800/60 ,  Y10T436/147777

摘要： Methods and devices for diagnosing, monitoring, or determining kidney transplant rejection or an associated disorder in a mammal are described. In particular, methods and devices for diagnosing, monitoring, or determining kidney transplant rejection or an associated disorder using measured concentrations of a combination of three or more analytes in a test sample taken from the mammal are described.

公开(公告)号：EP2462438A4

公开(公告)日：2013-01-23

申请号：EP10807278

申请日：2010-08-06

申请人： RULES BASED MEDICINE INC

发明人： SPAIN MICHAEL ,  MAPES JAMES P ,  LABRIE SAMUEL ,  MCDADE RALPH ,  EISINGER DOMINIC ,  BALLARD KARRI ,  SALOMON DANIEL ,  ABECASSIS MICHAEL

IPC分类号： G01N33/48 ,  G01N33/53 ,  G01N33/68

CPC分类号： G01N33/6893 ,  G01N33/5302 ,  G01N33/566 ,  G01N2333/47 ,  G01N2333/4703 ,  G01N2333/4706 ,  G01N2333/4725 ,  G01N2333/4727 ,  G01N2333/475 ,  G01N2333/52 ,  G01N2333/70503 ,  G01N2333/70539 ,  G01N2333/765 ,  G01N2333/775 ,  G01N2333/8139 ,  G01N2333/8146 ,  G01N2333/82 ,  G01N2333/91177 ,  G01N2800/34 ,  G01N2800/347 ,  G01N2800/52 ,  G01N2800/56 ,  G01N2800/60 ,  Y10T436/147777

摘要： Methods and devices for diagnosing, monitoring, or determining kidney transplant rejection or an associated disorder in a mammal are described. In particular, methods and devices for diagnosing, monitoring, or determining kidney transplant rejection or an associated disorder using measured concentrations of a combination of three or more analytes in a test sample taken from the mammal are described.

公开(公告)号：EP2462445A1

公开(公告)日：2012-06-13

申请号：EP10807275.2

申请日：2010-08-06

申请人： Rules-Based Medicine, Inc.

发明人： SPAIN, Michael, D. ,  MAPES, James, P. ,  LABRIE, Samuel, T. ,  MCDADE, Ralph, L. ,  EISINGER, Dominic ,  BALLARD, Karri, L.

IPC分类号： G01N33/543

CPC分类号： G01N33/6893 ,  G01N33/5302 ,  G01N33/566 ,  G01N2333/47 ,  G01N2333/4703 ,  G01N2333/4706 ,  G01N2333/4725 ,  G01N2333/4727 ,  G01N2333/475 ,  G01N2333/52 ,  G01N2333/70503 ,  G01N2333/70539 ,  G01N2333/765 ,  G01N2333/775 ,  G01N2333/8139 ,  G01N2333/8146 ,  G01N2333/82 ,  G01N2333/91177 ,  G01N2800/34 ,  G01N2800/347 ,  G01N2800/52 ,  G01N2800/56 ,  G01N2800/60 ,  Y10T436/147777

摘要： Methods and devices for diagnosing, monitoring, or determining kidney transplant rejection or an associated disorder in a mammal are described. In particular, methods and devices for diagnosing, monitoring, or determining kidney transplant rejection or an associated disorder using measured concentrations of a combination of three or more analytes in a test sample taken from the mammal are described.

公开(公告)号：EP1904846A4

公开(公告)日：2009-03-18

申请号：EP06799967

申请日：2006-06-27

申请人： RULES BASED MEDICINE INC

发明人： CHANDLER MARK B ,  SPAIN MICHAEL D ,  MAPES JAMES ,  RODGERS GEORGE

IPC分类号： G01N33/53 ,  G01N33/00 ,  G01N33/573

CPC分类号： C12Q1/48 ,  C12Q1/37 ,  G01N33/573 ,  G01N33/6893 ,  G01N2333/91188 ,  G01N2333/96486 ,  G01N2800/324

摘要： Provided are methods for the detection and diagnosis of acute coronary syndrome or ACS. The methods are based on the discovery that abnormal levels of selected analytes in sample fluid, typically blood samples, of patients who are at risk are supportive of a diagnosis of ACS. At least two new biomarkers for ACS are thus disclosed, MMP-3 and SGOT. Altogether the concentrations of twelve analytes provide a sensitive and selective picture of the patient's condition, namely, whether the patient is suffering a heart attack. Other important biomarkers for ACS are described, including but not limited to IL-18, Factor VII, ICAM-1, Creatine Kinase-MB, MCP-I, Myoglobin, C Reactive Protein, von Willebrand Factor, TIMP-1, Ferritin, Glutathione S-Transferase, Prostate Specific Antigen (free), IL-3, Tissue Factor, alpha-Fetoprotein, Prostatic Acid Phosphatase, Stem Cell Factor, MIP-1-beta, Carcinoembryonic Antigen, IL-13, TNF-alpha, IgE, Fatty Acid Binding Protein, ENA-78, IL-1-beta, Brain-Derived Nerotrophic Factor, Apolipoprotein A1, Serum Amyloid P, Growth Hormone, Beta-2 microglobulin, Lipoprotein (a), MMP-9, Thyroid Stimulating hormone, alpha-2 Macroglobulin, Complement 3, IL-7, Leptin, and IL-6. Kits containing reagents to assist in the analysis of fluid samples are also described.