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    DRY CHEMICAL TEST STRIP WITH MULTIPLE LAYERS OF MEMBRANES BASED ON CONCENTRATION GRADIENT
    1.
    发明授权
    DRY CHEMICAL TEST STRIP WITH MULTIPLE LAYERS OF MEMBRANES BASED ON CONCENTRATION GRADIENT 有权

    公开(公告)号：EP3264081B1

    公开(公告)日：2018-08-01

    申请号：EP15882969.7

    申请日：2015-02-28

    申请人： Zeng, Rongbin

    发明人： Zeng, Rongbin

    IPC分类号： G01N33/52

    CPC分类号： G01N33/525 ,  G01N33/00 ,  G01N2333/90283 ,  G01N2333/904 ,  G01N2333/91074 ,  G01N2333/916

    摘要： A dry chemical test strip with multiple layers of membranes based on concentration gradient, comprising a substrate (1), an indicator layer (2), a reagent layer (3) and a diffusion layer (5), which are arranged successively from bottom to top, and further comprises a concentration gradient layer (4), which is arranged on the upper or lower surface of the reagent layer (3). Wherein a first reagent is uniformly applied on the reagent layer (3), and a second reagent is applied on the concentration gradient layer (4). The concentration gradient ˆ‡ Á of the second reagent is 0 in the width direction of the test strip, and is a constant or a function of the variable of length in the length direction of the test strip, and a chromogenic reagent is uniformly applied on the indicator layer (2). The dry chemical test strip with multiple layers of membranes based on concentration gradient can enable a continuous stepless change in the concentration distribution of the reagent on the test strip, allow all the testing and analysis procedures to be directly carried out on the test strip, and enable a test result to be directly obtained on the spot without the help of an instruments.

    DRY CHEMICAL TEST STRIP WITH MULTIPLE LAYERS OF MEMBRANES BASED ON CONCENTRATION GRADIENT
    4.
    发明公开
    DRY CHEMICAL TEST STRIP WITH MULTIPLE LAYERS OF MEMBRANES BASED ON CONCENTRATION GRADIENT 有权
    基于浓度梯度的多层膜干燥化学试验条

    公开(公告)号：EP3264081A1

    公开(公告)日：2018-01-03

    申请号：EP15882969.7

    申请日：2015-02-28

    申请人： Zeng, Rongbin

    发明人： Zeng, Rongbin

    IPC分类号： G01N33/52

    CPC分类号： G01N33/525 ,  G01N33/00 ,  G01N2333/90283 ,  G01N2333/904 ,  G01N2333/91074 ,  G01N2333/916

    摘要： A dry chemical test strip with multiple layers of membranes based on concentration gradient, comprising a substrate (1), an indicator layer (2), a reagent layer (3) and a diffusion layer (5), which are arranged successively from bottom to top, and further comprises a concentration gradient layer (4), which is arranged on the upper or lower surface of the reagent layer (3). Wherein a first reagent is uniformly applied on the reagent layer (3), and a second reagent is applied on the concentration gradient layer (4). The concentration gradient ∇ ρ of the second reagent is 0 in the width direction of the test strip, and is a constant or a function of the variable of length in the length direction of the test strip, and a chromogenic reagent is uniformly applied on the indicator layer (2). The dry chemical test strip with multiple layers of membranes based on concentration gradient can enable a continuous stepless change in the concentration distribution of the reagent on the test strip, allow all the testing and analysis procedures to be directly carried out on the test strip, and enable a test result to be directly obtained on the spot without the help of an instruments.

    摘要翻译： 本发明公开了一种干式化学试纸条，包括基片（1），指示剂层（2），试剂层（3）和扩散层（5），所述干化学试片具有基于浓度梯度的多层膜， 并且还包括布置在试剂层（3）的上表面或下表面上的浓度梯度层（4）。 其中，第一试剂均匀涂布在试剂层（3）上，第二试剂涂布在浓度梯度层（4）上。 第二试剂的浓度梯度在测试条的宽度方向上为0，并且是测试条长度方向上的长度变量的常数或函数，并且显色剂均匀地施加在 指示层（2）。 基于浓度梯度的多层膜的干化学测试条可以使试剂在试条上的浓度分布连续无级变化，允许在试条上直接进行所有测试和分析程序，并且 无需仪器的帮助即可直接获得测试结果。

    DRY CHEMICAL TEST STRIP WITH MULTIPLE LAYERS OF MEMBRANES BASED ON CONCENTRATION GRADIENT
    6.
    发明公开
    DRY CHEMICAL TEST STRIP WITH MULTIPLE LAYERS OF MEMBRANES BASED ON CONCENTRATION GRADIENT 有权

    公开(公告)号：EP3264081A4

    公开(公告)日：2018-01-03

    申请号：EP15882969

    申请日：2015-02-28

    申请人： ZENG RONGBIN

    发明人： ZENG RONGBIN

    IPC分类号： G01N33/52

    CPC分类号： G01N33/525 ,  G01N33/00 ,  G01N2333/90283 ,  G01N2333/904 ,  G01N2333/91074 ,  G01N2333/916

    摘要： A dry chemical test strip with multiple layers of membranes based on concentration gradient, comprising a substrate (1), an indicator layer (2), a reagent layer (3) and a diffusion layer (5), which are arranged successively from bottom to top, and further comprises a concentration gradient layer (4), which is arranged on the upper or lower surface of the reagent layer (3). Wherein a first reagent is uniformly applied on the reagent layer (3), and a second reagent is applied on the concentration gradient layer (4). The concentration gradient ˆ‡ Á of the second reagent is 0 in the width direction of the test strip, and is a constant or a function of the variable of length in the length direction of the test strip, and a chromogenic reagent is uniformly applied on the indicator layer (2). The dry chemical test strip with multiple layers of membranes based on concentration gradient can enable a continuous stepless change in the concentration distribution of the reagent on the test strip, allow all the testing and analysis procedures to be directly carried out on the test strip, and enable a test result to be directly obtained on the spot without the help of an instruments.

    Verfahren zum Nachweis von Störungen des Protein C/Protein S-Systems
    10.
    发明公开
    Verfahren zum Nachweis von Störungen des Protein C/Protein S-Systems 失效
    Verfahren zum Nachweis vonStörungendes Protein C / Protein S-Systems

    公开(公告)号：EP0696642A1

    公开(公告)日：1996-02-14

    申请号：EP95111554.2

    申请日：1995-07-22

    申请人： BEHRINGWERKE Aktiengesellschaft

    发明人： Kraus, Michael, Dr.

    IPC分类号： C12Q1/56

    CPC分类号： G01N33/86 ,  G01N2333/462 ,  G01N2333/745 ,  G01N2333/91074 ,  G01N2333/9108 ,  G01N2333/91085 ,  G01N2333/96461 ,  G01N2405/04 ,  Y10S514/834

    摘要： Die vorliegende Erfindung betrifft ein Verfahren zum Nachweis von Störungen des Protein C/Protein S-Systems durch ein Verfahren zum qualitativen Nachweis und zur quantitativen Bestimmung der funktionellen Aktivität des Protein C/Protein S-Systems der Gerinnung in einer Probe einer biologischen Flüssigkeit, das folgende Schritte einschließt:

    a) Zugabe eines Aktivators des Protein C zu der verdünnten oder unverdünnten Probe;
    b) optionale Zugabe eines Kontaktphaseaktivators;
    c) Inkubation des Reaktionsansatzes;
    d) Start des Gerinnungsablaufes durch Zugabe von Kalziumionen und/oder anderen Gerinnungs-auslösenden Agenzien und
    e) Bestimmung der Gerinnungsaktivität.

    摘要翻译： 检测或确定。 蛋白质C /蛋白S系统在生物流体中的凝血功能活性包括：（a）将蛋白C激活剂（A）加入到选择性中。 稀释样品; （b）选择 加入接触相活化剂（B）; （c）孵化混合物; （d）通过加入Ca离子和/或其它凝血诱导剂引发凝血，和（e）测量凝血活性。 还要求：（1）试剂 （A），（B）和磷脂（PL）和（2）测试试剂盒 这样的试剂。