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    TANDEM DIFFERENTIAL MOBILITY ION MOBILITY SPECTROMETRY
    4.
    发明公开
    TANDEM DIFFERENTIAL MOBILITY ION MOBILITY SPECTROMETRY 审中-公开

    公开(公告)号：EP4403911A1

    公开(公告)日：2024-07-24

    申请号：EP24153527.7

    申请日：2024-01-23

    Applicant: Hamilton Sundstrand Corporation

    Inventor： Gardner, Ben D. ,  Eicemen, Gary A. ,  Fwler,Peter

    IPC: G01N27/624 ,  H01J49/00

    CPC classification number: G01N27/624 ,  H01J49/0045

    Abstract: In accordance with at least one aspect of this disclosure, a method for identifying a chemical composition includes, collecting a chemical sample and introducing the chemical sample to a detection system, performing, with a differential mobility spectrometer (112), differential mobility spectrometry on the chemical sample to separate ions within the chemical sample into a first constituent group based on a first analysis characteristic. Performing differential mobility spectrometry on the chemical sample further comprises, filtering the ions within the ionized flow such that only ions having a desired mobility pass to a fragmenter, and fragmenting the filtered sample to further dissociate ions within the filtered sample to generate additional ion types having distinctive mobility characteristics.

    DUCTING GAS OF MASS SPECTROMETER
    6.
    发明公开
    DUCTING GAS OF MASS SPECTROMETER 审中-公开

    公开(公告)号：EP4358115A1

    公开(公告)日：2024-04-24

    申请号：EP23202802.7

    申请日：2023-10-10

    Applicant: Thermo Finnigan LLC

    Inventor： QUARMBY, Scott T. ,  MAZE, Joshua T.

    IPC: H01J49/00 ,  H01J49/06 ,  H01J49/24

    CPC classification number: H01J49/24 ,  H01J49/067 ,  H01J49/0045

    Abstract: A mass spectrometer includes a vacuum chamber, a pump for maintaining a vacuum chamber at an operating vacuum pressure, an ion source, a first mass filter configured to select precursor ions, a collision/reaction cell pressurized with a collision or reaction gas and configured to generate a plurality of product ions from the precursor ions by colliding or reacting the precursor ions with one or more gas particles, and a second mass filter configured to select target ions from the product ions. Also provided are entrance and exit lenses between the collision/reaction cell and the first and second mass filters, respectively, each of which include axially-spaced ion lenses and evacuation chambers between adjacent ion lenses. A plenum fluidly connects the evacuation chambers to the pump inlet to facilitate evacuation of collision or reaction gas escaping the collision/reaction cell to the pump away from the first and second mass filters.

    HYBRID MASS SPECTROMETER
    7.
    发明公开
    HYBRID MASS SPECTROMETER 审中-公开

    公开(公告)号：EP3410463A1

    公开(公告)日：2018-12-05

    申请号：EP17174365.1

    申请日：2017-06-02

    Applicant: Thermo Fisher Scientific (Bremen) GmbH

    Inventor： GIANNAKOPULOS, Anastassios ,  MAKAROV, Alexander ,  HOCK, Christian Albrecht ,  DAMOC, Nicolaie Eugen ,  STEWART, Hamish

    IPC: H01J49/00 ,  H01J49/40 ,  H01J49/42

    CPC classification number: H01J49/0031 ,  H01J49/0045 ,  H01J49/10 ,  H01J49/40 ,  H01J49/425

    Abstract: A data independent acquisition method of mass spectrometry for analysing a sample within a mass range of interest. The method is performed within a time period based on a width of a chromatographic peak of the sample as it elutes from a chromatography system. The method comprising the steps of ionising the sample to produce a plurality of precursor ions, selecting precursor ions within a mass range of interest to be analysed, performing at least one MS1 scan of the precursor ions and performing a set of MS2 scans. Performing the MS1 scan comprises mass analysing precursor ions across the mass range of interest using a Fourier Transform mass analyser for identification and/or quantitation of the precursor ions in the MS1 domain. Performing the set of MS2 scans comprises segmenting the precursor ions into a plurality of precursor mass segments, each precursor mass segment having a mass range of no greater than 5 amu, and for each precursor mass segment fragmenting the precursor ions within that precursor mass segment and performing an MS2 scan of the fragmented ions. The MS2 scan is performed by forming an ion packet from the fragmented ions and injecting the ion packet of fragmented ions into a time of flight mass analyser (150) and mass analysing the fragmented ions.

    DECONVOLUTION OF MIXED SPECTRA
    8.
    发明公开
    DECONVOLUTION OF MIXED SPECTRA 审中-公开

    公开(公告)号：EP3335237A1

    公开(公告)日：2018-06-20

    申请号：EP16834737.5

    申请日：2016-08-09

    Applicant: DH Technologies Development PTE. Ltd.

    Inventor： COX, David Michael ,  IVOSEV, Gordana

    IPC: H01J49/30 ,  H01J49/00

    CPC classification number: H01J49/0031 ,  H01J49/0027 ,  H01J49/004 ,  H01J49/0045 ,  H01J49/04 ,  H01J49/26

    Abstract: An m/z range of an ion beam is divided into two or more precursor ion mass selection windows. A pattern of two or more different window m/z ranges to be used during two or more successive cycles for at least one precursor ion mass selection window is determined. The pattern includes an initial window m/z range and one or more successively different window m/z ranges. Each of the one or more successively different window m/z ranges includes at least a portion of the initial window m/z range. A tandem mass spectrometer is instructed to select and fragment the two or more precursor ion mass selection windows during each cycle of a plurality of cycles and to repeatedly use the pattern for each group of two or more successive cycles of the plurality of cycles for the selection and fragmentation of the at least one precursor ion mass selection window.

    POST-IONIZATION OF NEUTRALS FOR ION MOBILITY OTOFMS IDENTIFICATION OF MOLECULES AND ELEMENTS DESORBED FROM SURFACES
    9.
    发明公开
    POST-IONIZATION OF NEUTRALS FOR ION MOBILITY OTOFMS IDENTIFICATION OF MOLECULES AND ELEMENTS DESORBED FROM SURFACES 审中-公开

    公开(公告)号：EP2389681A4

    公开(公告)日：2017-11-15

    申请号：EP10733952

    申请日：2010-01-23

    Applicant: IONWERKS INC

    Inventor： SCHULTZ J ALBERT ,  EGAN THOMAS F ,  WATERS KELLEY L ,  LEWIS ERNEST K

    IPC: H01J49/00 ,  G01N27/62 ,  H01J49/10 ,  H01J49/40

    CPC classification number: H01J49/40 ,  G01N27/622 ,  H01J49/0027 ,  H01J49/0045 ,  H01J49/107

    Abstract: The present invention relates to a method and apparatus for ionizing a neutral MALDI desorption plume, and in particular, for efficiently measuring the ionized MALDI desorption plume when post-ionization techniques are combined with a medium pressure MALDI-IM-oTOFMS instrument. Additionally, the present disclosure provides a method and apparatus that simultaneously separates tissue-sample MALDI ions by IM-oTOFMS according to their chemical family. After separation, the MALDI ions are directly compared to the ions created by post-ionizing the co-desorbed neutral molecules with a second laser wherein the second laser is delayed by a few hundred microseconds. The present disclosure further provides novel approaches that enhance the analysis of ions, including the use of giant fullerene internal standards to enhance mass accuracy, and ultraviolet (UV) declustering lasers to generate intact peptides and proteins, either of which may be followed by VUV post-ionization which generates identifiable structural fragments.

    SYSTEMS AND METHODS FOR SUPPRESSING UNWANTED IONS
    10.
    发明公开
    SYSTEMS AND METHODS FOR SUPPRESSING UNWANTED IONS 审中-公开
    用于抑制有害离子的系统和方法

    公开(公告)号：EP3216044A1

    公开(公告)日：2017-09-13

    申请号：EP15856924.4

    申请日：2015-10-30

    Applicant: PerkinElmer Health Sciences, Inc.

    Inventor： BADIEI, Hamid ,  BAZARGAN, Samad

    IPC: H01J49/26

    CPC classification number: H01J49/061 ,  H01J49/00 ,  H01J49/0031 ,  H01J49/0045 ,  H01J49/005 ,  H01J49/0072 ,  H01J49/0077 ,  H01J49/10 ,  H01J49/105 ,  H01J49/24

    Abstract: A mass spectrometer is provided that is configurable for operation in both a Kinetic Energy Discrimination (KED) mode and a dynamic reaction cell (DRC) mode. To operate in the KED mode, a collision cell can be filled with a quantity of the inert gas, and an energy barrier can be formed between the collision cell and a downstream mass analyzer. To operate instead in the DRC mode, the collision cell can be filled with a quantity of gas that is reactive with the interferer ions.

    Abstract translation: 提供可配置为在动能判别（KED）模式和动态反应池（DRC）模式下操作的质谱仪。 为了在KED模式下操作，碰撞池可以填充一定量的惰性气体，并且碰撞池和下游质量分析仪之间可以形成能量屏障。 为了在DRC模式下操作，碰撞池可以填充一定量的与干扰离子反应的气体。

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