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公开(公告)号：EP1654287B1
公开(公告)日：2010-08-11
申请号：EP04764037.0
申请日：2004-08-16
申请人： Merck Patent GmbH
CPC分类号： C07K16/2887 , A61K2039/505 , C07K16/3076 , C07K2317/24 , C07K2317/52 , C07K2317/56 , C07K2317/732 , C07K2317/734 , C07K2319/00 , Y10S424/80 , Y10S424/801
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2.发明授权Therapeutic application of chimeric antibodies to human B lymphocyte restricted differentiation antigen for treatment of B cell lymphoma 失效嵌合的和标记的抗体的治疗用途其针对一个分化抗原，其表达仅限于人B淋巴细胞为B细胞淋巴瘤的治疗
公开(公告)号：EP1005870B1
公开(公告)日：2009-01-21
申请号：EP99123967.4
申请日：1993-11-12
申请人： Biogen Idec Inc.
发明人： Anderson, Darrell R. , Hanna, Nabil , Leonard, John E. , Newman, Roland A. , Reff, Mitchell E. , Rastetter, William H.
CPC分类号： C07K16/2887 , A61K38/00 , A61K47/6849 , A61K51/1027 , A61K51/1093 , A61K2039/505 , C07K2317/24 , C07K2317/56 , C07K2317/732 , C07K2319/00 , C12N2799/028 , Y10S424/80 , Y10S424/801 , Y10S530/808 , Y10S530/809 , Y10S530/867
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3.发明公开TREATMENT OF INTERMEDIATE- AND HIGH-GRADE NON-HODGKINS LYMPHOMA WITH ANTI-CD20 ANTIBODY 审中-公开HOHENMALIGNITÄTSGRADES麻省理工学院麻省理工学院抗体CD20抗生素
公开(公告)号：EP1227836A4
公开(公告)日：2005-06-22
申请号：EP00955249
申请日：2000-08-02
申请人： IDEC PHARMA CORP
IPC分类号： A61K51/00 , A61K39/395 , A61P35/00 , C07K16/28 , C12P21/08 , A61K39/00 , A61K49/16 , A61K51/10 , A61M36/06 , G01N33/15 , G01N33/50 , G01N33/53
CPC分类号： C07K16/2887 , A61K31/475 , A61K31/573 , A61K31/664 , A61K31/675 , A61K31/704 , A61K35/28 , A61K35/545 , A61K39/3955 , A61K39/39558 , A61K2039/505 , C07K2317/24 , Y10S424/801 , A61K2300/00
摘要： This invention discloses methods for the treatment of intermediate- and high-grade non-Hodgkins lymphomas comprising administration of anti-CD20 antibodies.
摘要翻译： 本发明公开了治疗中，高级非霍奇金淋巴瘤的方法，包括施用抗CD20抗体。
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公开(公告)号：EP0778891B1
公开(公告)日：2004-10-20
申请号：EP95929923.1
申请日：1995-09-01
发明人： EDELMAN, Léna , MARGARITTE, Christel,San Francisco General , KACZOREK, Michel , CHAABIHI, Hassan
IPC分类号： C12N15/13 , C07K16/34 , A61K39/395 , C12N15/86
CPC分类号： C12N15/86 , A61K38/00 , C07K16/34 , C12N2710/14143 , Y10S424/80 , Y10S424/801 , Y10S530/866 , Y10S530/867
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5.发明公开Therapeutic application of chimeric antibodies to human B lymphocyte restricted differentiation antigen for treatment of B cell lymphoma 失效嵌合的和标记的抗体的治疗用途其针对一个分化抗原，其表达仅限于人B淋巴细胞为B细胞淋巴瘤的治疗
公开(公告)号：EP1005870A2
公开(公告)日：2000-06-07
申请号：EP99123967.4
申请日：1993-11-12
发明人： Anderson, Darrell R. , Hanna, Nabil , Leonard, John E. , Newman, Roland A. , Reff, Mitchell E. , Rastetter, William H.
CPC分类号： C07K16/2887 , A61K38/00 , A61K47/6849 , A61K51/1027 , A61K51/1093 , A61K2039/505 , C07K2317/24 , C07K2317/56 , C07K2317/732 , C07K2319/00 , C12N2799/028 , Y10S424/80 , Y10S424/801 , Y10S530/808 , Y10S530/809 , Y10S530/867
摘要： Disclosed herein is an immunologically active, chimeric anti-CD20 antibody for use as a medicament, which antibody is capable of substantial B-cell depletion when administered to a subject.
摘要翻译： 公开在是用作药物，所述抗体能够大幅B细胞耗竭当施用给受试者的免疫活性的，嵌合的抗CD20抗体。
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6.发明公开$i(RUPESTRIS) STEM PITTING ASSOCIATED VIRUS NUCLEIC ACIDS, PROTEINS, AND THEIR USES 失效蛋白质和BY $ I（一枝）应变相关病毒核酸及其应用
公开(公告)号：EP0989992A1
公开(公告)日：2000-04-05
申请号：EP98923613.8
申请日：1998-05-20
发明人： GONSALVES, Dennis , MENG, Baozhong
CPC分类号： C12N15/8283 , C07K14/005 , C12N2770/26022 , C12Q1/701 , Y10S424/801
摘要： The present invention relates to an isolated protein or polypeptide corresponding to a protein or polypeptide of a Rupestris stem pitting associated virus. The encoding DNA molecule, either alone in isolated form, in an expression system, a host cell, or a transgenic grape plant, is also disclosed. Other aspects of the present invention relate to a method of imparting Rupestris stem pitting associated virus resistance to grape plants by transforming them with the DNA molecule of the present invention, and a method of detecting the presence of a Rupestris stem pitting associated virus, such as RSPaV-1, in a sample.
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公开(公告)号：EP0977991A1
公开(公告)日：2000-02-09
申请号：EP98906582.6
申请日：1998-02-20
发明人： STARLING, Gary, C. , SIADAK, Anthony, W. , BOWEN, Michael, A. , ARUFFO, Alejandro , BAJORATH, Jurgen , BODIAN, Dale, L. , SKONIER, John, E.
IPC分类号： G01N33/567 , C12N5/08 , C07K16/28 , C12P21/08
CPC分类号： C07K14/70596 , A61K38/00 , C07K16/2896 , C07K2317/34 , C07K2319/00 , Y10S424/801 , Y10S530/808 , Y10S530/864
摘要： The invention provides antibodies and other binding agents that bind specifically to SRCR domains of human CD6 (hCD6) and have advantageous properties, including the capacity to substantially inhibit binding of activated leukocyte adhesion molecule (ALCAM) to hCD6. The binding agents of the invention are useful, inter alia, in methods for screening peptides and drugs that also bind to hCD6 and/or modulate ALCAM binding to hCD6, as well as in diagnostic and therapeutic methods for management and treatment of inflammatory and autoimmune diseases.
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8.发明公开ANTI-FELINE HERPESVIRUS-1 RECOMBINANT ANTIBODY AND GENE FRAGMENT CODING FOR SAID ANTIBODY. 失效重组抗体针对猫疱疹病毒-1基因片段和编码它们。
公开(公告)号：EP0671472A4
公开(公告)日：1997-11-19
申请号：EP94901002
申请日：1993-11-25
IPC分类号： A61K39/395 , A61K38/00 , A61P31/12 , C07K14/00 , C07K14/03 , C07K16/00 , C07K16/08 , C12N15/02 , C12N15/09 , C12N15/13 , C12P21/08 , C12R1/91 , C12N15/62
CPC分类号： C07K16/085 , A61K38/00 , C07K2317/24 , C07K2319/00 , Y10S424/80 , Y10S424/801 , Y10S424/809
摘要： An anti-feline herpesvirus-1 recombinant antibody which is efficacious in treating, preventing and diagnosing feline herpesvirus-1 (FHV-1) infection, and a gene fragment useful for the preparation of the antibody. A gene fragment coding for the antibody V region bearing an FHV-1 specific avidity of a mouse monoclonal antibody having an excellent activity of neutralizing FHV-1 is obtained by constructing cells which produce the antibody. A chimeric anti-FHV-1 recombinant antibody is prepared from the above gene fragment and another gene fragment coding for a feline antibody C region.
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公开(公告)号：EP0778891A1
公开(公告)日：1997-06-18
申请号：EP95929923.0
申请日：1995-09-01
CPC分类号： C12N15/86 , A61K38/00 , C07K16/34 , C12N2710/14143 , Y10S424/80 , Y10S424/801 , Y10S530/866 , Y10S530/867
摘要： Cloning of DNA fragments which code for the light chain or the heavy chain variable domain of the D7C2 monoclonal antibody within a baculovirus. The invention also concerns the expression of these DNA fragments in insect host cells, the anti-rhesus D recombinant monoclonal antibody so obtained and its use.
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公开(公告)号：EP0347433A1
公开(公告)日：1989-12-27
申请号：EP88907749.0
申请日：1988-09-05
申请人： CELLTECH LIMITED
CPC分类号： C07K16/3015 , C07K16/00 , C07K16/30 , Y10S424/801 , Y10S530/867
摘要： The present invention provides an altered antibody molecule (AAM) having a hinge region which has a different number of cysteine residues from that found in the hinge region normally associated with the CH1 domain of the antibody molecule and a process for producing the same using recombinant DNA technology.
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