PROCESS FOR THE PREPARATION OF 3-(3-CHLORO-1H-PYRAZOL-1-YL)PYRIDINE
    4.
    发明公开
    PROCESS FOR THE PREPARATION OF 3-(3-CHLORO-1H-PYRAZOL-1-YL)PYRIDINE 审中-公开
    制备3-(3-氯-1H-吡唑-1-基)吡啶的方法

    公开(公告)号:EP3174856A1

    公开(公告)日:2017-06-07

    申请号:EP14899042.7

    申请日:2014-10-17

    CPC分类号: C07D401/04

    摘要: 3-(3-Chloro-1H-pyrazol-1-yl)pyridine is prepared by cyclizing 3-hydrazinopyridine-.dihydrochloride with commercially available 3-ethoxyacrylonitrile to provide 3-(3-amino-1H-pyrazol-1-yl)pyridine, and by converting the amino group to a chloro group by a Sandmeyer reaction.

    摘要翻译: 通过用市售3-乙氧基丙烯腈环化3-肼基吡啶 - 二盐酸盐制备3-(3-氯-1H-吡唑-1-基)吡啶,得到3-(3-氨基-1H-吡唑-1-基)吡啶, 并通过Sandmeyer反应将氨基转化为氯基。