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1.
公开(公告)号:EP2064239A2
公开(公告)日:2009-06-03
申请号:EP07842088.2
申请日:2007-09-07
申请人: Amgen, Inc
发明人: HAN, Hq , CHEN, Qing , KWAK, Keith, Soo-Nyung , ZHOU, Xiaolan
IPC分类号: C07K16/00
CPC分类号: C07K16/22 , A61K2039/505 , C07K2317/14 , C07K2317/21 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/76 , C07K2317/92
摘要: The disclosure provides compositions and methods relating to or derived from anti-activin A binding proteins, including antibodies. In particular embodiments, the disclosure provides fully human, humanized, and chimeric anti-activin A antibodies that bind human activin A, activin A-binding fragments and derivatives of such antibodies, and activin A-binding polypeptides comprising such fragments. Other embodiments provide nucleic acids encoding such antibodies, antibody fragments and derivatives and polypeptides, cells comprising such polynucleotides, methods of making such antibodies, antibody fragments and derivatives and polypeptides, and methods of using such antibodies, antibody fragments and derivatives and polypeptides, including methods of treating or diagnosing subjects having activin A-related disorders or conditions including cachexia related to gonadal cancer, other cancers, rheumatoid arthritis, and other diseases.
摘要翻译: 本公开提供与抗激活素A结合蛋白(包括抗体)相关或衍生的组合物和方法。 在具体实施方案中,本公开提供了完全人,人源化和嵌合的抗激活素A抗体,其结合人激活素A,激活素A结合片段和此类抗体的衍生物,以及包含此类片段的激活素A-结合多肽。 其他实施方案提供编码此类抗体,抗体片段和衍生物和多肽的核酸,包含此类多核苷酸的细胞,制备此类抗体的方法,抗体片段和衍生物和多肽,以及使用此类抗体,抗体片段和衍生物和多肽的方法,包括方法 治疗或诊断具有激活素A相关疾病或包括与性腺癌,其他癌症,类风湿性关节炎和其他疾病相关的恶病质的病症的受试者。
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2.
公开(公告)号:EP3133084A1
公开(公告)日:2017-02-22
申请号:EP16178026.7
申请日:2007-09-07
申请人: Amgen Inc.
发明人: HAN, Hq , CHEN, Qing , KWAK, Keith Soo-Nyung , ZHOU, Xiaolan
IPC分类号: C07K16/22 , A61K39/395 , C12N15/13 , A61P5/06 , A61P9/10 , A61P35/00 , A61P37/00 , A61P43/00
摘要: The disclosure provides compositions and methods relating to or derived from anti-activin A binding proteins, including antibodies. In particular embodiments, the disclosure provides fully human, humanized, and chimeric anti-activin A antibodies that bind human activin A, activin A-binding fragments and derivatives of such antibodies, and activin A-binding polypeptides comprising such fragments. Other embodiments provide nucleic acids encoding such antibodies, antibody fragments and derivatives and polypeptides, cells comprising such polynucleotides, methods of making such antibodies, antibody fragments and derivatives and polypeptides, and methods of using such antibodies, antibody fragments and derivatives and polypeptides, including methods of treating or diagnosing subjects having activin A-related disorders or conditions including cachexia related to gonadal cancer, other cancers, rheumatoid arthritis, and other diseases.
摘要翻译: 本公开提供与抗激活素A结合蛋白(包括抗体)相关或衍生的组合物和方法。 在具体实施方案中,本公开提供了完全人,人源化和嵌合的抗激活素A抗体,其结合人激活素A,激活素A结合片段和此类抗体的衍生物,以及包含此类片段的激活素A-结合多肽。 其他实施方案提供编码此类抗体,抗体片段和衍生物和多肽的核酸,包含此类多核苷酸的细胞,制备此类抗体的方法,抗体片段和衍生物和多肽,以及使用此类抗体,抗体片段和衍生物和多肽的方法,包括方法 治疗或诊断具有激活素A相关疾病或包括与性腺癌,其他癌症,类风湿性关节炎和其他疾病相关的恶病质的病症的受试者。
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公开(公告)号:EP2132314B1
公开(公告)日:2016-11-30
申请号:EP08742032.9
申请日:2008-03-06
申请人: Amgen Inc.
IPC分类号: C12N15/12 , C07K14/71 , C12N15/861 , A61K38/17 , C12N5/10
CPC分类号: C07K14/71 , A61K38/00 , C07K2319/00 , C07K2319/30
摘要: The present invention provides variant activin IIB soluble receptor polypeptides and proteins capable of binding and inhibiting the activities of activin A, myostatin, or GDF-11. The present invention also provides polynucleotides, vectors and host cells capable of producing the variant polypeptides and proteins. Compositions and methods for treating muscle-wasting and other diseases and disorders are also provided.
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公开(公告)号:EP2064239B1
公开(公告)日:2014-11-26
申请号:EP07842088.2
申请日:2007-09-07
申请人: Amgen Inc.
发明人: HAN, Hq , CHEN, Qing , KWAK, Keith, Soo-Nyung , ZHOU, Xiaolan
IPC分类号: C07K16/22 , A61K39/395 , A61P35/00
CPC分类号: C07K16/22 , A61K2039/505 , C07K2317/14 , C07K2317/21 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/76 , C07K2317/92
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公开(公告)号:EP3101029B1
公开(公告)日:2019-04-03
申请号:EP16179980.4
申请日:2009-11-24
申请人: Amgen, Inc
发明人: SUN, Jeonghoon , TAM, Lei-Ting Tony , MICHAELS, Mark Leo , BOONE, Thomas C. , DESHPANDE, Rohini , LI, Yue-Sheng , HAN, Hq
IPC分类号: C07K14/705 , C07K14/71 , C07K14/72
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公开(公告)号:EP2370463B1
公开(公告)日:2016-08-31
申请号:EP09761055.4
申请日:2009-11-24
申请人: Amgen Inc.
发明人: SUN, Jeonghoon , TAM, Lei-Ting Tony , MICHAELS, Mark Leo , BOONE, Thomas C. , DESHPANDE, Rohini , LI, Yue-Sheng , HAN, Hq
IPC分类号: C07K14/495 , C07K14/71
CPC分类号: C07K14/71 , A61K38/00 , C07K14/495
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7.
公开(公告)号:EP2606066A1
公开(公告)日:2013-06-26
申请号:EP11745910.7
申请日:2011-08-15
申请人: Amgen Inc.
发明人: HAN, Hq , ARORA, Taruna , CHEN, Qing , LU, Hsieng Sen , ZHOU, Xiaolan
CPC分类号: C07K16/26 , A61K2039/505 , C07K16/22 , C07K2317/14 , C07K2317/34 , C07K2317/565 , C07K2317/76 , C07K2317/92 , Y02A50/466
摘要: Myostatin antagonists, including myostatin binding antibodies, are disclosed. Also disclosed are nucleic acids encoding and cells including myostatin antagonists; methods of production; and methods of use.
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公开(公告)号:EP3495388A1
公开(公告)日:2019-06-12
申请号:EP18203136.9
申请日:2007-09-07
申请人: Amgen Inc.
发明人: HAN, Hq , CHEN, Qing , KWAK, Keith Soo-Nyung , ZHOU, Xiaolan
IPC分类号: C07K16/22 , A61K39/395 , C12N15/13 , A61P5/06 , A61P9/10 , A61P35/00 , A61P37/00 , A61P43/00
摘要: The disclosure provides compositions and methods relating to or derived from anti-activin A binding proteins, including antibodies. In particular embodiments, the disclosure provides fully human, humanized, and chimeric anti-activin A antibodies that bind human activin A, activin A-binding fragments and derivatives of such antibodies, and activin A-binding polypeptides comprising such fragments. Other embodiments provide nucleic acids encoding such antibodies, antibody fragments and derivatives and polypeptides, cells comprising such polynucleotides, methods of making such antibodies, antibody fragments and derivatives and polypeptides, and methods of using such antibodies, antibody fragments and derivatives and polypeptides, including methods of treating or diagnosing subjects having activin A-related disorders or conditions including cachexia related to gonadal cancer, other cancers, rheumatoid arthritis, and other diseases.
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公开(公告)号:EP3730517A1
公开(公告)日:2020-10-28
申请号:EP20175809.1
申请日:2007-09-07
申请人: Amgen, Inc
发明人: HAN, Hq , CHEN, Qing , KWAK, Keith Soo-Nyung , ZHOU, Xiaolan
IPC分类号: C07K16/22 , A61K39/395 , C12N15/13 , A61P5/06 , A61P9/10 , A61P35/00 , A61P37/00 , A61P43/00 , A61P1/00 , A61P3/04 , A61P5/00 , A61P7/00 , A61P9/00 , A61P19/02 , A61P29/00
摘要: The disclosure provides compositions and methods relating to or derived from anti-activin A binding proteins, including antibodies. In particular embodiments, the disclosure provides fully human, humanized, and chimeric anti-activin A antibodies that bind human activin A, activin A-binding fragments and derivatives of such antibodies, and activin A-binding polypeptides comprising such fragments. Other embodiments provide nucleic acids encoding such antibodies, antibody fragments and derivatives and polypeptides, cells comprising such polynucleotides, methods of making such antibodies, antibody fragments and derivatives and polypeptides, and methods of using such antibodies, antibody fragments and derivatives and polypeptides, including methods of treating or diagnosing subjects having activin A-related disorders or conditions including cachexia related to gonadal cancer, other cancers, rheumatoid arthritis, and other diseases.
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公开(公告)号:EP3133084B1
公开(公告)日:2020-06-24
申请号:EP16178026.7
申请日:2007-09-07
申请人: Amgen Inc.
发明人: HAN, Hq , CHEN, Qing , KWAK, Keith Soo-Nyung , ZHOU, Xiaolan
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