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    New physiologically active substance erbstatin analogous compounds
    5.
    发明公开
    New physiologically active substance erbstatin analogous compounds 失效
    新的生理活性物质ERBSTATIN类似物

    公开(公告)号：EP0238868A3

    公开(公告)日：1988-01-07

    申请号：EP87102543

    申请日：1987-02-23

    申请人： Zaidanhojin Biseibutsu Kagaku Kenkyukai

    发明人： Umezawa, Hamao ,  Tatsuta, Kuniaki ,  Takeuchi, Tomio ,  Isshiki, Kunio ,  Imoto, Masaya

    IPC分类号： C07C119/02 ,  C07C103/38 ,  A61K31/275 ,  A61K31/16 ,  A01N37/18 ,  A01N47/40

    CPC分类号： C07C251/00

    摘要： The present invention provides new physiological active substance erbstatin analogue compounds of a general formula (I), which have excellent tyrosine-specific protein-kinase inhibitory activity, antitumor activity and antimicrobial activity.
    in which R 1 represents a hydrogen atom, a lower alkanoyl group or a lower alkyl group; n represents a positive integer of
    1 to3; X represents a hydrogen atom or a halogen atom; Y represents a group of formula -CH=CH-NC, -CH=CH-NHR 2 or-CH 2 -CH 2 -NHR 2 (where R 2 represents a formyl group or a lower alkanoyl group; with the exception of the cases where X is hydrogen atom, (R 1 0) n group is 2,5-dihydroxy group and Y is -CH=CH-NHCHO or-CH 2 -CH 2 -NHCHO). The present invention further provides a tyrosine-specific protein-kinase inhibitor, tumoricide or bactericide containing at least one compound of the said formula (I).

    Sesquiterpenoid isocyanide composition and its methods of use
    8.
    发明公开
    Sesquiterpenoid isocyanide composition and its methods of use 失效
    倍半萜类化合物异氰酸酯酶

    公开(公告)号：EP0285302A1

    公开(公告)日：1988-10-05

    申请号：EP88302483.8

    申请日：1988-03-22

    申请人： HARBOR BRANCH OCEANOGRAPHIC INSTITUTION, INC.

    发明人： Wright, Amy E. ,  McCarthy, Peter. ,  Cross, Sue Shipley ,  Rake, James B. ,  McConnell, Oliver J.

    IPC分类号： C07C119/02 ,  A61K31/275

    CPC分类号： C07C403/02 ,  C07C2601/14

    摘要： This invention relates to a novel composition which is useful as an antitumor, antiviral and antifungal composition, a process of producing the composition and a method for inhibiting tumors, viruses, and fungi utilizing the composition. More particularly, the novel composition is an organic sesquiterpenoid isocyanide composition which is derived from marine sponge Bubaris sp., and has the general formula:

    摘要翻译： 本发明涉及一种可用作抗肿瘤，抗病毒和抗真菌组合物的新型组合物，该组合物的制备方法以及利用该组合物抑制肿瘤，病毒和真菌的方法。 更具体地说，新型组合物是衍生自海洋海绵Bubaris sp。的有机倍半萜烯异氰酸酯组合物，具有以下通式： a

    New physiologically active substance erbstatin analogous compounds
    9.
    发明公开
    New physiologically active substance erbstatin analogous compounds 失效
    erbstatin的生理活性类似物。

    公开(公告)号：EP0238868A2

    公开(公告)日：1987-09-30

    申请号：EP87102543.3

    申请日：1987-02-23

    申请人： Zaidanhojin Biseibutsu Kagaku Kenkyukai

    发明人： Umezawa, Hamao ,  Tatsuta, Kuniaki ,  Takeuchi, Tomio ,  Isshiki, Kunio ,  Imoto, Masaya

    IPC分类号： C07C119/02 ,  C07C103/38 ,  A61K31/275 ,  A61K31/16 ,  A01N37/18 ,  A01N47/40

    CPC分类号： C07C251/00

    摘要： The present invention provides new physiological active substance erbstatin analogue compounds of a general formula (I), which have excellent tyrosine-specific protein-kinase inhibitory activity, antitumor activity and antimicrobial activity.
    in which R 1 represents a hydrogen atom, a lower alkanoyl group or a lower alkyl group; n represents a positive integer of

    1 to3;
    X represents a hydrogen atom or a halogen atom;
    Y represents a group of formula -CH=CH-NC, -CH=CH-NHR 2 or-CH 2 -CH 2 -NHR 2
    (where R 2 represents a formyl group or a lower alkanoyl group; with the exception of the cases where X is hydrogen atom, (R 1 0) n group is 2,5-dihydroxy group and Y is -CH=CH-NHCHO or-CH 2 -CH 2 -NHCHO).

    The present invention further provides a tyrosine-specific protein-kinase inhibitor, tumoricide or bactericide containing at least one compound of the said formula (I).