公开(公告)号：EP1178968A4

公开(公告)日：2002-06-19

申请号：EP00930725

申请日：2000-05-15

申请人： SQUIBB BRISTOL MYERS CO

发明人： KIM SOONG-HOON ,  JOHNSON JAMES A

IPC分类号： C07B61/00 ,  C07D417/06 ,  C07F7/18 ,  C07D225/02 ,  C07D225/04 ,  C07D313/06 ,  C07D313/16

CPC分类号： C07D417/06

摘要： The invention as claimed is directed to a process for making an epothilone having structures (II) or (IV) from ones having an oxiranyl moiety, by reacting a compound having the latter structure with a metal or metal-assisted reagent. Said metal or metal-assisted reagent is selected from the group consisting of a) reactive metallocenes; b) [N2C(CO2Me)2, cat Rh2,(OAC)4]; c) [N2C(CO2Me)2, cat[(n-C7H15CO2)2 Rh]2]; d) [Zn-Cu, EtOH]; e) [Mg(Hg), MgBr]; f) Cr; g) [FeCl3, n-BuLi]; h) [TiCl3, LiAlH4]; i) [TiCl4, Zn]; j) [WCl6, LiAlH4]; k) [NbCl5, NaAlH4]; l) [VCl3,Zn] and m) [WCl6, n-BuLi].

公开(公告)号：EP1178968A1

公开(公告)日：2002-02-13

申请号：EP00930725.7

申请日：2000-05-15

申请人： BRISTOL-MYERS SQUIBB COMPANY

发明人： KIM, Soong-Hoon ,  JOHNSON, James, A.

IPC分类号： C07D225/02 ,  C07D225/04 ,  C07D313/06 ,  C07D313/16

CPC分类号： C07D417/06

摘要： The invention as claimed is directed to a process for making an epothilone having structures (II) or (IV) from ones having an oxiranyl moiety, by reacting a compound having the latter structure with a metal or metal-assisted reagent. Said metal or metal-assisted reagent is selected from the group consisting of a) reactive metallocenes; b) [N2C(CO2Me)2, cat Rh2,(OAC)4]; c) [N2C(CO2Me)2, cat[(n-C7H15CO2)2 Rh]2]; d) [Zn-Cu, EtOH]; e) [Mg(Hg), MgBr]; f) Cr; g) [FeCl3, n-BuLi]; h) [TiCl3, LiAlH4]; i) [TiCl4, Zn]; j) [WCl6, LiAlH4]; k) [NbCl5, NaAlH4]; l) [VCl3,Zn] and m) [WCl6, n-BuLi].

摘要翻译： 所要求保护的本发明涉及一种通过使具有后面结构的化合物与金属或金属辅助试剂反应来制备具有结构式（II）或（IV）的埃坡霉素的方法中的具有环氧乙烷基部分的埃坡霉素的方法。 所述金属或金属辅助试剂选自：a）反应性金属茂; b）[N2C（CO2Me）2，cat Rh2，（OAC）4]; c）[N2C（CO2Me）2，cat [（n-C7H15CO2）2Rh] 2]; d）[Zn-Cu，EtOH]; e）[Mg（Hg），MgBr]; f）Cr; g）[FeCl 3，n-BuLi]; h）[TiCl 3，LiAlH 4]; i）[TiCl4，Zn]; j）[WCl6，LiAlH4]; k）[NbCl 5，NaAlH 4]; l）[VCl3，Zn]和m）[WCl6，n-BuLi]。