公开(公告)号：EP0113561A3

公开(公告)日：1985-05-08

申请号：EP83307541

申请日：1983-12-12

申请人： THE UPJOHN COMPANY

发明人： Pearlman, Bruce Allen

IPC分类号： C07H09/04 ,  C07C177/00 ,  C07D493/04 ,  C07F09/535 ,  C07F09/53 ,  C07D317/00 ,  C07D307/00

CPC分类号： C07H9/04 ,  C07C405/00 ,  C07C405/0016 ,  C07C405/0025 ,  C07C405/0041 ,  C07C2601/08 ,  C07F9/4006

摘要： Prostaglandins such as 9-deoxo-9-methylene-16,16-dimethyl-PGE 2 , PGE 2 and PGF 2α are prepared by a novel process, from D-glucose. The process involves a number of steps, including the preparation of novel intermediates including 2,3-disubstituted-4,5-tetrahydrofurandiols protected with the, for example, 2,2-propylidene radical.

公开(公告)号：EP0178669A3

公开(公告)日：1987-04-08

申请号：EP85113205

申请日：1985-10-17

申请人： Takeda Chemical Industries, Ltd.

发明人： Oka, Youichi ,  Yokoyama, Masao ,  Dairaku, Toshiaki

IPC分类号： B01J19/18 ,  C07B37/00 ,  C07H09/04

CPC分类号： C07H9/04 ,  B01J19/18 ,  B01J2219/00094 ,  B01J2219/00159 ,  B01J2219/00162 ,  B01J2219/00164 ,  B01J2219/00182 ,  B01J2219/185 ,  Y02P20/582

摘要： An apparatus and a method for carrying out the dehydration reaction to produce a high boiling compound comprises charging a raw material and an organic solvent into a circulating system including a reactor, a preheater and an evaporator to cause the chemical dehydration reaction, drawing water, formed as a result of the dehydration reaction, together with the solvent in the form of vapor, compressing the vapor, effecting a heat exchange between the compressed vapor and the evaporator, dehydrating the compressed vapor by condensation, removing the dehydrated water out of the system, and returning the remaining solvent to the reactor.

公开(公告)号：EP0139486A3

公开(公告)日：1985-05-29

申请号：EP84306499

申请日：1984-09-24

申请人： Takeda Chemical Industries, Ltd.

发明人： Matsumura, Koichi

IPC分类号： C07H09/04

CPC分类号： C07H9/04

摘要： A process is disclosed for production of a sugar ketal, which comprises reacting a sugar with a ketone in the presence of antimony pentachloride or antimony pentafluoride. The process offers characteristic features that the reaction can be allowed to proceed fully in a small amount of the catalyst, the objective sugar ketal being obtained in improved yields.

公开(公告)号：EP0027908A3

公开(公告)日：1981-08-05

申请号：EP80105893

申请日：1980-09-29

申请人： BAYER AG

发明人： Kinast, Günther, Dr. ,  Müller, Lutz, Dr. ,  Sitt, Rüdiger, Dr. ,  Puls, Walter, Dr.

IPC分类号： C07D211/46 ,  C07D211/54 ,  C07H09/04 ,  C07H15/12 ,  C07D498/04 ,  A61K31/445 ,  C07D263/00 ,  C07D221/00

CPC分类号： C07H9/04 ,  C07D211/46 ,  C07H7/02 ,  Y10S514/824 ,  Y10S514/835 ,  Y10S514/866

公开(公告)号：EP0191464A3

公开(公告)日：1988-06-01

申请号：EP86101742

申请日：1986-02-12

申请人： BASF Aktiengesellschaft

发明人： Pfaff, Klaus-Peter, Dr. ,  Paust, Joachim, Dr. ,  Hartmann, Horst

IPC分类号： C07H09/04

CPC分类号： C07H9/04

摘要： Verfahren zur Herstellung von Zuckerketalen durch Umsetzen von Zuckern mit Ketonen in Gegenwart von einem sauren Katalysator, das dadurch gekennzeichnet ist, dass man
A. eine Bortrifluorid-Molekülverbindung oder Trifluor methansulfonsäure in Mengen von nur 0,01 bis 10 Gew.-%, bezogen auf eingesetzten Zucker, verwendet,
B. das Keton in bis zu 30fach molarem Überschuss ein setzt und
C. das bei der Reaktion gebildete Wasser laufend aus dem Reaktionsgemisch entfernt.
Besonders vorteilhaft gestaltet sich das Verfahren, wenn man das Bortrifluorid als Bortrifluorid-Etherat ein setzt, dieses bzw. die Trifluormethansulfonsäure nach Be endigung der Umsetzung unter nichtwässrigen Bedingun gen unwirksam macht und anschliessend das Reaktionsge misch nach Abdampfen des Ketons einer fraktionierten Destilation unterwirft. Besondere Bedeutung hat das Ver fahren für die Umsetzung von L-Sorbose mit Aceton zu der für die Synthese von Ascorbinsäure benötigten 2,3;4,6-Di-O- isopropyliden-L-sorbofuranose.

公开(公告)号：EP0138441A3

公开(公告)日：1986-08-27

申请号：EP84306512

申请日：1984-09-25

申请人： McNeilab, Inc.

发明人： Maryanoff, Bruce Eliot ,  Gardocki, Joseph Francis

IPC分类号： C07C143/00 ,  C07D309/06 ,  C07H09/04 ,  A61K31/095 ,  A61K31/35 ,  A61K31/70

CPC分类号： C07H9/04 ,  C07D309/06

摘要： Sulfamates of the following formula (I):
wherein X is O or CH 2 and R 1 , R 2 , R 3 , R 4 and R 5 are as herein defined have been found to exhibit anticonvulsant activity and are thus useful in the treatment of conditions such as epilepsy. Further, pharmaceutical compositions containing a compound of formula (I) as well as methods for their use and intermediates form part of the present invention.

公开(公告)号：EP0173614A3

公开(公告)日：1986-08-13

申请号：EP85401575

申请日：1985-08-01

申请人： ZAIDAN HOJIN BISEIBUTSU KAGAKU KENKYU KAI

发明人： Umezawa, Hamao ,  Umezawa, Sumio ,  Tsuchiya Tsutomu ,  Takahashi, Yoshiaki

IPC分类号： C07H15/234 ,  A61K31/70 ,  C07H09/04

CPC分类号： C07H15/234 ,  C07H9/04 ,  Y02P20/55

摘要： A new compound, 3'-fluoro-3'-deoxykanamycin A is now provided, which is active against gram-negative and gram-positive bacteria, including kanamycin-resistant strains of bacteria and is useful as antibacterial agent for therapeutic treatment of bacterial infections. This new compound is produced by a process comprising reacting a 6- azido-2,4-di-O-protected-3,6-dideoxy-3-fluoro-α-D-glucopyranosyl bromide with the 4-hydroxyl group of a 6-0-(2'-0- protected-3'-N-protected-3'-amino-4',6'-di-O-protected-3'-deoxy-a-D-glucopyranosyl)-1,3-bis-N-protected-2-deoxystreptamine, reducing the azido group of the resulting reaction product into an amino group, and removing the remaining protective groups from the reduction product.