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    ENZYMATIC PRODUCTION OF TIACUMICIN B (FIDAXOMICIN)
    4.
    发明授权
    ENZYMATIC PRODUCTION OF TIACUMICIN B (FIDAXOMICIN) 有权
    台勾霉素B的酶法生产（非达霉素）

    公开(公告)号：EP2882860B1

    公开(公告)日：2016-05-04

    申请号：EP13750659.8

    申请日：2013-07-30

    申请人： OLON S.p.A.

    发明人： TRIONE, Guido ,  MALCANGI, Antonella

    IPC分类号： C12P19/58 ,  C12P19/62

    CPC分类号： C12P19/58 ,  C07H17/08 ,  C12P19/62

    摘要： The present invention relates to a procedure for the production of tiacumicin B comprising fermentation of a micro-organism capable of producing tiacumicin B, in particular of the species Dactylosporangium aurantiacum or Actinoplanes deccanensis, in a culture broth containing emulsifiers, such as ethoxylated castor oil, in combination with antifoaming products and vegetable oils.

    FRUCTOSYLATED MANGIFERIN AND PREPARATION METHOD THEREFOR AND USE THEREOF
    6.
    发明公开
    FRUCTOSYLATED MANGIFERIN AND PREPARATION METHOD THEREFOR AND USE THEREOF 有权
    FRUCTOSYLATED MANGIFERIN及其制备方法及其用途

    公开(公告)号：EP2657245A1

    公开(公告)日：2013-10-30

    申请号：EP12807633.8

    申请日：2012-03-08

    申请人： Nanjing University of Technology

    发明人： HE, Bingfang ,  WU, Xueming ,  CHU, Jianlin ,  WU, Bin ,  ZHANG, Sen ,  OUYANG, Pingkai

    IPC分类号： C07H15/26 ,  A61K31/7048 ,  A61P35/00 ,  A61P35/02 ,  C12P19/58

    CPC分类号： C07H15/26 ,  C12P17/06 ,  C12P19/00 ,  C12P19/14

    摘要： Provided are a fructosylated mangiferin, a preparation method therefor and a use thereof, wherein the fructosylated mangiferin has a structural formula represented by the following formula (I), the method for preparing the fructosylated mangiferin includes adding a substance with fructosylating enzymatic activity to a transformed liquid containing mangiferin for biotransformation reaction, so as to convert the mangiferin into the fructosylated mangiferin, wherein the transformed liquid contains the mangiferin and a glycosyl donor; as well as a use of the fructosylated mangiferin in preparation of a medicament for treatment of tumor-related diseases.

    摘要翻译： 本发明提供一种果糖基化芒果苷及其制备方法及其用途，其中所述果糖基化芒果苷具有下式（I）所示的结构式，所​​述果糖基化芒果苷的制备方法包括将具有果糖基化酶活性的物质加入转化体 将含有芒果苷的液体进行生物转化反应，以将芒果苷转化为果糖基化芒果苷，其中转化液体含有芒果苷和糖基供体; 以及果糖基化芒果苷在制备用于治疗肿瘤相关疾病的药物中的用途。