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公开(公告)号：EP4417978A1
公开(公告)日：2024-08-21
申请号：EP22880821.8
申请日：2022-09-30
发明人： KAWABE, Toshiki , OGASAWARA, Kosuke , IIJIMA, Yumi
摘要： A method for analyzing a blood coagulation reaction comprises, by a blood coagulation analysis device, measuring a coagulation reaction of a sample solution including a subject blood specimen, determining whether or not the coagulation reaction of the sample solution is completed, and when it is determined that the coagulation reaction is completed, terminating measurement of the coagulation reaction of the sample solution. The blood coagulation analysis device includes a reaction table which is rotated in one direction, and the reaction table includes a measurement port to which a cell can be attached. The coagulation reaction of the sample solution in the cell supplied to the measurement port is measured, and time series data of the measured coagulation reaction is accumulated. Whether or not the coagulation reaction is completed is determined from the accumulated time series data of the coagulation reaction, and when it is determined that the coagulation reaction is completed, measurement of the coagulation reaction of the sample solution is terminated, and the cell containing the sample solution is removed from the measurement port.
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公开(公告)号：EP4386385A1
公开(公告)日：2024-06-19
申请号：EP22855879.7
申请日：2022-08-09
发明人： YAJI, Shohei , ITO, Shizuka , OKUYAMA, Shinya , OCHIAI, Yasushi , KOHNO, Keigo , WATANABE, Keisuke , HEWSON, Christopher Kenta , SAKAI, Shun
IPC分类号： G01N33/531 , G01N33/543
CPC分类号： G01N33/543 , G01N33/531
摘要： The present invention provides an immunoassay method for detecting a protein with an isoelectric point of 9.5 or higher, comprising a step of bringing a sample containing the protein with an isoelectric point of 9.5 or higher into contact with a glass material in the presence of a cationic substance, and an immunochromatography kit for detecting a protein with an isoelectric point of 9.5 or higher, comprising a specimen diluent and an immunochromatography test strip.
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3.发明公开
公开(公告)号：EP4317969A1
公开(公告)日：2024-02-07
申请号：EP22775655.8
申请日：2022-03-23
发明人： KOMAI, Kuniya , INOUE, Tomonori
IPC分类号： G01N33/48
摘要： Provided is a blood separation composition with which a partition wall can be satisfactorily formed even when the blood separation composition is stored for a long time. A blood separation composition according to the present invention contains an organic component having fluidity at 25°C and fine powder silica, the fine powder silica including hydrophobic silica having a hydrophobicity of 60% or more as measured by a methanol wettability method.
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公开(公告)号：EP4212880A1
公开(公告)日：2023-07-19
申请号：EP21866778.0
申请日：2021-09-08
发明人： KAWABE, Toshiki , ODA, Yukio
IPC分类号： G01N33/86
摘要： Provided is a blood coagulation reaction analysis method. The method includes measuring a blood coagulation reaction of a subject specimen and acquiring first data for calculating a blood coagulation time of the subject specimen and second data for estimating a blood coagulation abnormality factor of the subject specimen, wherein the acquiring of the second data includes: obtaining a first derivative V(i) of a coagulation reaction curve R(i); and determining a point p k where V(i) assumes X k before reaching a maximum value of V(i), Vmax, and a point q k where V(i) assumes X k after reaching Vmax.
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公开(公告)号：EP4212627A1
公开(公告)日：2023-07-19
申请号：EP21866847.3
申请日：2021-09-10
摘要： An object of the present invention is to provide a method for measuring an object to be measured in a specimen by an enzymatic method, the measurement method being able to suppress the positive influence of peroxide derived from the specimen. More specifically, an object of the present invention is to provide a measurement method and a measurement reagent that can suppress elevation in value regardless of whether or not the specimen is a catalase-free specimen. Provided is a measurement method that can accurately quantify hydrogen peroxide derived from an object to be measured, without influence derived from a specimen, by contacting the specimen with an enzyme in the presence of at least one compound selected from the group consisting of a compound represented by the following general formula (I), a benzimidazole derivative having an electron-donating substituent at position 2, and histidine, wherein R1 and R2 are the same or different and each represent hydrogen, a linear or branched alkyl group having 1 to 6 carbon atoms and optionally having a substituent, an aryl group optionally having a substituent, or an alkyloxy group having 1 to 6 carbon atoms.
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6.发明公开
公开(公告)号：EP4130745A1
公开(公告)日：2023-02-08
申请号：EP21777082.5
申请日：2021-03-24
发明人： YAJI Maasa , INABA Yuya , KITAHARA Shinichiro , WAKIYA Takeshi , YAMAGAMI Mai , OBINATA Shuhei
IPC分类号： G01N33/543 , G01N33/553
摘要： Disclosed is a sensitized magnetic responsive particle including: a magnetic responsive particle having a core particle and at least one magnetic layer disposed on the core particle, the magnetic layer containing microparticles of a magnetic metal and/or an oxide thereof; and a substance that specifically interacts with an analyte, the substance being supported on the magnetic responsive particle, wherein, assuming that a volume and a weight of the core particle are respectively v c and w c , and that a volume and a weight of the magnetic responsive particle are respectively v e and w e , the magnetic material density [(w e - w c )/(v e - v c )] satisfies the following expression 1: 2.0 ≤ w e − w c / v e − v c The magnetic responsive particle has a high magnetic collection property in spite of a small particle size. When the magnetic responsive particle is used, a reagent for an immunoassay having excellent magnetic separability and capable of realizing high sensitivity can be provided.
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公开(公告)号：EP4119941A1
公开(公告)日：2023-01-18
申请号：EP21768942.1
申请日：2021-03-12
发明人： UMETSU, Mina , NEMOTO, Yuriko , TAIRA, Hiroaki
摘要： Provided is a hemoglobin assay method by which HbA0 fraction can be separated with high accuracy.
The hemoglobin assay method includes allowing elution of a fraction containing hemoglobin A0 by ion exchange chromatography using an eluent containing a buffer at a concentration of less than 25 mM, wherein the buffer is a phosphate or a Good's buffer, and the eluent has a pH within ± 0.1 of a pKa of the buffer.-
公开(公告)号：EP4108772A1
公开(公告)日：2022-12-28
申请号：EP21757281.7
申请日：2021-02-19
发明人： EBINUMA Hiroyuki , SUZUKI Ikumi
IPC分类号： C12N15/12 , C12Q1/686 , C12Q1/6876 , C12N9/00
摘要： It is an object of the present disclosure to provide a method for reducing the influence of baseline disturbances in a method for detecting a target nucleic acid in dry blood filter paper by real-time PCR using a fluorescent dye, with a simple method. The present disclosure provides a method for detecting a target nucleic acid in dry blood filter paper by real-time PCR, the method including: (1) amplifying the target nucleic acid in the dry blood filter paper by applying thermal cycles to a sample solution containing a dry blood filter paper punch piece and a PCR reagent, wherein the PCR reagent includes a fluorescently labeled probe; (2) optically detecting the fluorescence intensity of the sample solution for each of the thermal cycles; and (3) performing quantitative analysis of the target nucleic acid using data after a predetermined number of cycles of the optically detected data.
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公开(公告)号：EP4102231A1
公开(公告)日：2022-12-14
申请号：EP20918005.8
申请日：2020-12-17
发明人： KAWABE, Toshiki , NISHIO, Tomohisa , MATSUSHITA, Hirotoshi , TAKIMORI, Shota , YAMAGUCHI, Toyomi
IPC分类号： G01N35/02
摘要： An automatic analysis apparatus is provided which is capable of stirring a reagent without reducing the analysis processing capacity, with a simple configuration.
An automatic analysis apparatus of the invention includes a reagent table 34 that is rotatable and that holds reagent vessels 74, and a plurality of magnets 36 are disposed below the reagent table 34, with orientations of magnetic poles of the magnets 36 fixed, along a movement path R of the reagent vessels 74 moving on a circumference when the reagent table 34 is rotationally driven. The plurality of magnets 36 are disposed such that the fixed orientations of the magnetic poles of the magnets vary along the movement path R, and act a magnetic force on a stirring bar 39 in each of the reagent vessels 74. When the reagent table 34 is rotated and the reagent vessels 74 pass above the magnets 36, the stirring bar 39 in each of the reagent vessels 34 is rotated and/or oscillated by the magnetic force received from the magnets 36, to stir the reagent.-
公开(公告)号：EP4083630A1
公开(公告)日：2022-11-02
申请号：EP20906355.1
申请日：2020-12-25
发明人： KAWABE, Toshiki
IPC分类号： G01N33/86
摘要： Provided is a blood coagulation time measurement method. In the method, reaction X(i) is acquired through smoothing and zero-point adjustment of a measured value P(i) for coagulation reaction of a blood specimen, and then an integration ratio Z(i) of the reaction X(i) is acquired. These values are used to calculate an index for coagulation time Tc calculation, and it is determined whether or not the index satisfies the criteria. The procedure is sequentially repeated until an index that satisfies the criteria is obtained.
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