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公开(公告)号：EP4416154A1
公开(公告)日：2024-08-21
申请号：EP22802564.9
申请日：2022-10-12
发明人： AMOUSSA, Machoud , BENZ, Joerg , BLAISING, Julie Elisabeth Françoise , GIROUD, Maude , GRETHER, Uwe , KROLL, Carsten , KUHN, Bernd , MARTIN, Rainer E. , O'HARA, Fionn Susannah , PUELLMANN, Bernd , RITTER, Martin , ROMBACH, Didier , SCHMID, Philipp Claudio , WITTWER, Matthias Beat
IPC分类号： C07D487/10 , C07D498/10 , A61K31/407 , A61K31/4166 , A61K31/424
CPC分类号： C07D498/10
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公开(公告)号：EP4400100A1
公开(公告)日：2024-07-17
申请号：EP23382025.7
申请日：2023-01-13
申请人： Instituto de Investigación Biomédica de Salamanca De la Fundación Instituto Ciencia de la Salud De Castilla y León , Universidad De Salamanca
IPC分类号： A61K31/167 , A61K31/277 , A61K31/4166 , A61K31/4439 , A61K31/451 , A61K31/496 , A61P35/00
CPC分类号： A61K31/4166 , A61K31/451 , A61K31/4439 , A61K31/277 , A61K31/167 , A61K31/496 , A61P35/00
摘要： The present invention refers to antiandrogens, particularly nonsteroidal antiandrogens, or salts derived thereof, for use in the treatment of cancer, wherein the cancer is characterized by the presence of androgen receptor-negative (AR-) tumor cells.
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公开(公告)号：EP3283115B1
公开(公告)日：2024-06-12
申请号：EP16714718.0
申请日：2016-03-28
IPC分类号： A61K31/137 , A61K31/197 , A61K31/198 , A61K31/20 , A61K31/4166 , A61K31/55 , A61P25/00 , A61K45/06
CPC分类号： A61K45/06 , A61K31/137 , A61K31/197 , A61K31/198 , A61K31/20 , A61K31/4166 , A61K31/55 , A61P25/00 , A61P25/18 , A61P43/00
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公开(公告)号：EP4349332A3
公开(公告)日：2024-05-15
申请号：EP24150920.7
申请日：2019-05-14
发明人： Yang, Wenjin , Chang, Kai-Wei , Liu, Suying , Tsai, Cheng-Han
IPC分类号： C07D401/14 , C07D401/04 , C07D409/04 , A61K31/4166 , A61P11/00
CPC分类号： C07D401/04 , C07D401/14 , C07D409/04 , A61P11/00
摘要： Hydantoin based compounds useful as inhibitors of matrix metalloproteinases (MMPs), particularly macrophage elastase (MMP-12) are described. Also described are related compositions and methods of using the compounds to inhibit MMP-12 and treat diseases mediated by MMP-12, such as asthma, chronic obstructive pulmonary disease (COPD), emphysema, acute lung injury, idiopathic pulmonary fibrosis (IPF), sarcoidosis, systemic sclerosis, liver fibrosis, nonalcoholic steatohepatitis (NASH), arthritis, cancer, heart disease, inflammatory bowel disease (IBD), acute kidney injury (AKI), chronic kidney disease (CKD), Alport syndrome, and nephritis.
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6.发明公开
公开(公告)号：EP4364734A1
公开(公告)日：2024-05-08
申请号：EP22833577.4
申请日：2022-06-28
发明人： HAN, Jeong Seok , PARK, Yong Kyu , BANG, Sung Hun , KIM, Jae Hyun , JANG, Ha Lim , KIM, Ye Rin , LEE, Su Kyoung , LIM, Taek Joo
IPC分类号： A61K31/4166 , A61P13/12 , A23K20/137
CPC分类号： A23K20/137 , A61P13/12 , A61K31/4166
摘要： Disclosed are a pharmaceutical composition for animals containing 5-hydroxy-1-methylimidazolidine-2,4-dione as an active ingredient, more specifically, a composition for preventing or treating kidney disease in animals containing 5-hydroxy-1-methylimidazolidine-2,4-dione or a pharmaceutically acceptable salt thereof as an active ingredient, a method of treating kidney disease in animals using the compound, and a functional feed for preventing or ameliorating kidney disease in animals containing the compound as an active ingredient. The 5-hydroxy-1-methylimidazolidine-2,4-dione can effectively ameliorate and treat symptoms of kidney disease when administered to companion animals such as dogs or cats with kidney disease. Therefore, there are provided a novel agent and method for treating kidney disease of animals that can effectively treat kidney disease, which is the cause of high mortality in companion animals.
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7.发明公开
公开(公告)号：EP4247371A1
公开(公告)日：2023-09-27
申请号：EP21827282.1
申请日：2021-11-18
发明人： BRADLEY, William, D. , CUI, Jike , SUN, Kaiming , TROJER, Patrick , WANG, Jing , WU, Rentian
IPC分类号： A61K31/4433 , A61K31/4166 , A61K45/06 , A61P35/00 , A61P35/04
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公开(公告)号：EP4211116A1
公开(公告)日：2023-07-19
申请号：EP21773522.4
申请日：2021-09-06
发明人： CHENG, Zhanling , LERNER, Christian , LIU, Yongqiang , NETTEKOVEN, Matthias , PFLIEGER, Philippe , PUELLMANN, Bernd , WANG, Jianhua , WANG, Min , WANG, Yongguang , YANG, Song , ZHOU, Chengang
IPC分类号： C07D231/14 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , A61K31/4166 , A61K31/4178 , A61P31/04
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公开(公告)号：EP4196126A1
公开(公告)日：2023-06-21
申请号：EP21756066.3
申请日：2021-08-10
申请人： Pfizer Inc. , Astellas Pharma Inc.
发明人： ANDERS, Lars , KIM, Kimberly Hyunjung , LI, Danan , MCMILLAN, Elizabeth Anne , ROLLINS, Robert Andrew , VEENEMAN, Brendan Ayers
IPC分类号： A61K31/506 , A61K31/4166 , A61K38/00 , A61K31/4164 , A61K31/4439 , A61K31/58 , A61P35/00 , A61P35/04
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公开(公告)号：EP2785349B2
公开(公告)日：2022-11-09
申请号：EP12795842.9
申请日：2012-11-30
IPC分类号： A61K31/519 , A61P35/00 , A61K31/277 , A61K31/4166 , A61K31/58 , A61K31/5025 , A61P13/08
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