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公开(公告)号：EP4420726A3
公开(公告)日：2024-11-13
申请号：EP24168727.6
申请日：2016-03-17
申请人： ALLERGAN, INC.
发明人： JIAO, Jim , CHANG, Chin-Ming , GORE, Anuradha V. , GRAHAM, Richard S. , JORDAN, R. Scott , NEERVANNAN, Sesha , PUJARA, Chetan P. , SHEN, Jie , WARNER, Kevin S.
IPC分类号： A61K31/498 , A61K9/00 , A61K47/02 , A61K9/08 , A61K31/5377 , A61P27/06
摘要： Embodiments disclosed herein are directed to fixed compositions comprising brimonidine and timolol for lowering intraocular pressure and treating glaucoma.
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公开(公告)号：EP4452256A1
公开(公告)日：2024-10-30
申请号：EP22843653.1
申请日：2022-12-20
申请人： Astrazeneca AB
发明人： HAMERLIK, Petra
IPC分类号： A61K31/336 , A61K31/495 , A61K31/498 , A61K45/06 , A61P35/00 , A61K41/00
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公开(公告)号：EP4421070A1
公开(公告)日：2024-08-28
申请号：EP22883978.3
申请日：2022-10-18
申请人： Sapiensbio Inc.
发明人： YOON, Dong-Oh , RYOO, Kanghyun , LEE, Hyunseung , RYU, Incheol , JEONG, Eun Jeong , LEE, Myoungwoo , LEE, Jin Woo , KIM, Je Hak
IPC分类号： C07D403/06 , A61K31/498 , A61K31/5377 , A61K31/4985 , A61P11/00 , A61P43/00 , C07D401/06 , C07D241/40 , C07D401/12 , C07D487/04
CPC分类号： A61K31/498 , A61K31/4985 , A61K31/5377 , A61P11/00 , A61P43/00 , C07D241/40 , C07D401/06 , C07D401/12 , C07D403/06 , C07D487/04
摘要： The present invention relates to a novel compound that is effective in inhibiting fibrosis. The inventors confirmed that the compound has an effect of inhibiting actin polymerization and not only reduces the levels of all types of fibrosis biomarkers but also effectively inhibits the expression of α-SMA, which is a major causative factor of fibrosis. Therefore, the novel compound according to the present invention is expected to be effectively used as a preparation having an excellent effect of alleviating and inhibiting fibrosis to prevent and treat a fibrosis disease.
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公开(公告)号：EP4201929B1
公开(公告)日：2024-08-14
申请号：EP21217702.6
申请日：2021-12-24
IPC分类号： C07D401/04 , A61K31/498 , A61P35/00 , A61P35/02
CPC分类号： A61P35/00 , A61P35/02 , C07D401/04
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公开(公告)号：EP4370507A1
公开(公告)日：2024-05-22
申请号：EP22748490.4
申请日：2022-07-12
IPC分类号： C07D241/36 , C07D405/12 , A61P25/00 , A61K31/498
CPC分类号： C07D405/12 , C07D241/36 , A61P25/00
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公开(公告)号：EP4355749A1
公开(公告)日：2024-04-24
申请号：EP23797297.1
申请日：2023-04-27
申请人： Xinthera, Inc.
IPC分类号： C07D487/04 , A61K31/496 , A61K31/498 , A61K31/4985 , A61K31/517 , A61P35/00 , A61P35/04 , C07D471/04 , C07D491/048
CPC分类号： C07D491/04 , C07D487/04 , C07D471/04 , C07D401/14
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公开(公告)号：EP4355334A1
公开(公告)日：2024-04-24
申请号：EP22823742.6
申请日：2022-06-16
发明人： BLACK, Cameron , ZIMMERMANN, Michal
IPC分类号： A61K31/5377 , A61K31/444 , A61K31/498 , A61K31/553 , A61P35/00 , C07D401/12 , C07D401/14 , C07D471/04
CPC分类号： A61K31/498 , A61K31/5377 , A61P35/00 , A61K45/06
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8.发明公开
公开(公告)号：EP4349828A1
公开(公告)日：2024-04-10
申请号：EP22810495.6
申请日：2022-05-23
发明人： XU, Zusheng , LOU, Yangtong , SHEN, Jian , XIE, Tiegang , SUN, Qingrui , CHEN, Li , ZENG, Kun , JIN, Xin
IPC分类号： C07D403/02 , C07D403/04 , C07D239/84 , C07D401/04 , C07D487/04 , C07D498/04 , A61K31/41 , A61K31/4188 , A61K31/498 , A61K31/4985 , A61P35/00
摘要： A nitrogen-containing heterocyclic compound, a preparation method thereof and an application thereof. A nitrogen-containing heterocyclic compound represented by formula I, a pharmaceutically acceptable salt thereof, a stereoisomer thereof, a tautomer thereof, or an isotopic compound thereof. The nitrogen-containing heterocyclic compound is expected to be used for the treatment and/or prevention of multiple diseases related to Ras.
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公开(公告)号：EP3589323B1
公开(公告)日：2024-04-03
申请号：EP18707713.6
申请日：2018-02-28
IPC分类号： A61K31/437 , A61K31/438 , A61K31/4545 , A61K31/47 , A61K31/4965 , A61K31/498 , A61K45/06 , A61P31/06
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10.发明公开
公开(公告)号：EP4337653A1
公开(公告)日：2024-03-20
申请号：EP22816759.9
申请日：2022-06-01
发明人： WEEKS, Kevin , AUBÉ, Jeffrey , LI, Kelin , ZELLER, Meredith
IPC分类号： C07D401/12 , C07D241/12 , A61K31/498
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