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1.发明公开HETEROCYCLIC COMPOUNDS FOR TREATING OR PREVENTING DISORDERS CAUSED BY REDUCED NEUROTRANSMISSION OF SEROTONIN, NOREPHNEPHRINE OR DOPAMINE. 有权杂环化合物用于治疗或预防传染病DUE TO五羟色胺，NOREPHNEPHRIN或多巴胺减少的神经传递
公开(公告)号：EP2616460A1
公开(公告)日：2013-07-24
申请号：EP11764005.2
申请日：2011-09-12
IPC分类号： C07D403/04 , C07D409/04 , C07D241/38 , C07D243/10 , C07D401/04 , C07D403/10 , C07D405/04 , C07D405/10 , C07D409/10 , C07D413/10 , C07D417/04 , C07D417/10 , C07D471/04 , C07D491/04 , C07D495/04
CPC分类号： A61K31/498 , A61K31/499 , A61K31/501 , A61K31/502 , A61K31/506 , A61K31/517 , A61K31/5377 , A61K31/538 , A61K31/5513 , A61K31/695 , C07D241/38 , C07D241/42 , C07D243/10 , C07D243/12 , C07D401/04 , C07D401/10 , C07D403/04 , C07D403/10 , C07D405/04 , C07D405/10 , C07D409/04 , C07D409/10 , C07D413/10 , C07D417/04 , C07D417/10 , C07D471/04 , C07D491/04 , C07D495/04 , C07D498/04 , C07F7/10 , C07F7/1804 , C07F7/1856 , Y02P20/55
摘要： A heterocyclic compound represented by the general formula (1) or a salt thereof: wherein m, l, and n respectively represent an integer of 1 or 2; X represents -O- or -CH
2 -; R
1 represents hydrogen, a lower alkyl group, a hydroxy-lower alkyl group, a protecting group, or a tri-lower alkylsilyloxy-lower alkyl group; R
2 and R
3 , which are the same or different, each independently represent hydrogen or a lower alkyl group; or R
2 and R
3 are bonded to form a cyclo-C3-C8 alkyl group; and R
4 represents an aromatic group or a heterocyclic group, wherein the aromatic or heterocyclic group may have one or more arbitrary substituent(s).-
2.发明授权HETEROCYCLIC COMPOUNDS FOR TREATING OR PREVENTING DISORDERS CAUSED BY REDUCED NEUROTRANSMISSION OF SEROTONIN, NOREPHNEPHRINE OR DOPAMINE. 有权杂环化合物用于治疗或预防传染病DUE TO五羟色胺，NOREPHNEPHRIN或多巴胺减少的神经传递
公开(公告)号：EP2616460B1
公开(公告)日：2015-10-28
申请号：EP11764005.2
申请日：2011-09-12
IPC分类号： C07D403/04 , C07D409/04 , C07D241/38 , C07D243/10 , C07D401/04 , C07D403/10 , C07D405/04 , C07D405/10 , C07D409/10 , C07D413/10 , C07D417/04 , C07D417/10 , C07D471/04 , C07D491/04 , C07D495/04
CPC分类号： A61K31/498 , A61K31/499 , A61K31/501 , A61K31/502 , A61K31/506 , A61K31/517 , A61K31/5377 , A61K31/538 , A61K31/5513 , A61K31/695 , C07D241/38 , C07D241/42 , C07D243/10 , C07D243/12 , C07D401/04 , C07D401/10 , C07D403/04 , C07D403/10 , C07D405/04 , C07D405/10 , C07D409/04 , C07D409/10 , C07D413/10 , C07D417/04 , C07D417/10 , C07D471/04 , C07D491/04 , C07D495/04 , C07D498/04 , C07F7/10 , C07F7/1804 , C07F7/1856 , Y02P20/55
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3.发明授权N,N-SUBSTITUTED 3-AMINOPYRROLIDINE COMPOUNDS USEFUL AS MONOAMINES REUPTAKE INHIBITORS 有权N，N-二SUBSTIUIERTE健身3-氨基吡咯烷作为MONO胺回收抑制剂的
公开(公告)号：EP1881975B1
公开(公告)日：2014-01-08
申请号：EP06756356.9
申请日：2006-05-12
发明人： KURIMURA, Muneaki , TAIRA, Shinichi , TOMOYASU, Takahiro , ITO, Nobuaki , TAI, Kuninori , TAKEMURA, Noriaki , MATSUZAKI, Takayuki , MENJO, Yasuhiro , MIYAMURA, Shin , SAKURAI, Yohji , WATANABE, Akihito , SAKATA, Yasuyo , MASUMOTO, Takumi , AKAZAWA, Kohei , SUGINO, Harukiho , AMADA, Naoki , OHASHI, Satoshi , SHINOHARA, Tomoichi , SASAKI, Hirofumi , MORITA, Chisako , YAMASHITA, Junko , NAKAJIMA, Satoko
IPC分类号： C07D401/12 , C07D401/14 , C07D403/14 , C07D207/14 , C07D405/12 , C07D407/12 , A61K31/497 , A61K31/4439 , A61K31/40 , A61P25/00 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14 , C07D407/14
CPC分类号： C07D205/04 , C07D207/14 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D405/14 , C07D409/12 , C07D409/14 , C07D413/12 , C07D413/14 , C07D417/12 , C07D471/04 , C07D495/04 , C07F7/10
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公开(公告)号：EP0858452A1
公开(公告)日：1998-08-19
申请号：EP97933046.0
申请日：1997-07-29
发明人： MORI, Toyoki , TOMINAGA, Michiaki , TABUSA, Fujio , NAGAMI, Kazuyoshi , ABE, Kaoru , NAKAYA, Kenji , TAKEMURA, Isao , SHINOHARA, Tomoichi , TANADA, Yoshihisa , YAMAUCHI, Takahito
CPC分类号： C07D417/12 , C07D277/46 , C07D277/82 , C07D317/64 , C07D417/14 , C07D471/04 , C07D487/04
摘要： A thiazole compound of formula (I), wherein T is lower alkylene; u is 0 or 1; R?1 and R2¿ are the same or different and are each H, or lower alkyl, etc.; R3 is (1) or (2); R4 is H or lower alkanoyloxy-lower alkyl, which shows inhibitory activity or protein kinase C(PKC, Ca2+/phospholipid-depending serine/threonine protein phosphatase), and are useful as a protein kinase C inhibitor.
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5.发明公开
公开(公告)号：EP0765314A1
公开(公告)日：1997-04-02
申请号：EP95921112.0
申请日：1995-06-07
发明人： OGAWA, Hidenori 25-18, Nakakirai-Aza , KONDO, Kazumi 55-11, Nakakirai-Aza-Inamoto , YAMASHITA, Hiroshi , KAN, Keizo , MATSUZAKI, Takayuki , SHINOHARA, Tomoichi , TANADA, Yoshihisa , KURIMURA, Muneaki Naruto-Grand-Heights 503 , TOMINAGA, Michiaki , YABUUCHI, Yoichi
IPC分类号： A61K31 , A61P1 , A61P3 , A61P5 , A61P7 , A61P9 , A61P13 , A61P15 , A61P25 , A61P43 , C07D215 , C07D223 , C07D243 , C07D401 , C07D403 , C07D405 , C07D409 , C07D413 , C07D417 , C07D471 , C07D521
CPC分类号： C07D223/16 , C07D215/12 , C07D215/18 , C07D231/12 , C07D233/56 , C07D243/12 , C07D243/14 , C07D249/08 , C07D401/06 , C07D401/10 , C07D401/12 , C07D401/14 , C07D403/06 , C07D403/10 , C07D403/12 , C07D405/12 , C07D409/06 , C07D413/10 , C07D417/06 , C07D417/10 , C07D471/04
摘要： A benzoheterocyclic derivative of formula (1) and pharmaceutically acceptable salts thereof, which show excellent anti-vasopressin activity, vasopressin agonistic activity and oxytocin antagonistic activity, and are useful as a vasopressin antagonist, vasopressin agonist or oxytocin antagonist.
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公开(公告)号：EP3630729A1
公开(公告)日：2020-04-08
申请号：EP18732930.5
申请日：2018-05-31
发明人： SHINOHARA, Tomoichi , IWATA, Shin , ARAI, Kenta , ITO, Nobuaki , SUZUKI, Masaki
IPC分类号： C07D239/22 , C07D239/54 , A61K31/506 , A61P25/08
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7.发明授权N,N-SUBSTITUTED 3-AMINOPYRROLIDINE COMPOUNDS USEFUL AS MONOAMINES REUPTAKE INHIBITORS 有权N，N-取代的3-氨基吡咯烷化合物可用作单胺再用抑制剂
公开(公告)号：EP1881975B8
公开(公告)日：2014-04-09
申请号：EP06756356.9
申请日：2006-05-12
发明人： KURIMURA, Muneaki , TAIRA, Shinichi , TOMOYASU, Takahiro , ITO, Nobuaki , TAI, Kuninori , TAKEMURA, Noriaki , MATSUZAKI, Takayuki , MENJO, Yasuhiro , MIYAMURA, Shin , SAKURAI, Yohji , WATANABE, Akihito , SAKATA, Yasuyo , MASUMOTO, Takumi , AKAZAWA, Kohei , SUGINO, Haruhiko , AMADA, Naoki , OHASHI, Satoshi , SHINOHARA, Tomoichi , SASAKI, Hirofumi , MORITA, Chisako , YAMASHITA, Junko , NAKAJIMA, Satoko
IPC分类号： C07D401/12 , C07D401/14 , C07D403/14 , C07D207/14 , C07D405/12 , C07D407/12 , A61K31/497 , A61K31/4439 , A61K31/40 , A61P25/00 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14 , C07D407/14
CPC分类号： C07D205/04 , C07D207/14 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D405/14 , C07D409/12 , C07D409/14 , C07D413/12 , C07D413/14 , C07D417/12 , C07D471/04 , C07D495/04 , C07F7/10
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公开(公告)号：EP0858452B1
公开(公告)日：2002-03-13
申请号：EP97933046.1
申请日：1997-07-29
发明人： MORI, Toyoki , TOMINAGA, Michiaki , TABUSA, Fujio , NAGAMI, Kazuyoshi , ABE, Kaoru , NAKAYA, Kenji , TAKEMURA, Isao , SHINOHARA, Tomoichi , TANADA, Yoshihisa , YAMAUCHI, Takahito
IPC分类号： C07D277/82 , A61K31/425 , C07D417/12 , C07D277/46
CPC分类号： C07D417/12 , C07D277/46 , C07D277/82 , C07D317/64 , C07D417/14 , C07D471/04 , C07D487/04
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公开(公告)号：EP4370507A1
公开(公告)日：2024-05-22
申请号：EP22748490.4
申请日：2022-07-12
IPC分类号： C07D241/36 , C07D405/12 , A61P25/00 , A61K31/498
CPC分类号： C07D405/12 , C07D241/36 , A61P25/00
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公开(公告)号：EP3887358A1
公开(公告)日：2021-10-06
申请号：EP19820895.1
申请日：2019-11-29
发明人： SHINOHARA, Tomoichi , IWATA, Shin , SUZUKI, Masaki , ARAI, Kenta , ITO, Nobuaki , CHIBA, Takuya
IPC分类号： C07D239/34 , C07D239/54 , C07D401/04 , C07D403/04 , C07D405/04 , C07D413/04 , C07D417/04 , C07D471/04 , C07D487/04 , A61P25/08 , A61K31/506
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