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公开(公告)号：EP4460298A1
公开(公告)日：2024-11-13
申请号：EP23700440.3
申请日：2023-01-05
发明人： DELBECK, Martina , HAHN, Michael
IPC分类号： A61K31/4025 , A61K31/453 , A61P11/00
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公开(公告)号：EP2734552B1
公开(公告)日：2024-11-13
申请号：EP12735916.4
申请日：2012-07-20
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公开(公告)号：EP4458842A1
公开(公告)日：2024-11-06
申请号：EP22901639.9
申请日：2022-11-18
发明人： JANG, Jae-Hyung , KIM, Yoo Jin
IPC分类号： C07K14/005 , A61K48/00 , A61P9/12 , C12N15/86 , A61P11/00
摘要： The present invention relates to a mutant of the adeno-associated virus serotype 1 (AAV1) capsid protein, a nucleic acid coding for the mutant of the AAV1 capsid protein, a recombinant AAV1 vector carrying the nucleic acid coding for the mutant of the AAV1 capsid protein, and a pharmaceutical composition comprising the vector, wherein the mutant has cysteine substituted for serine at position 430 and valine substituted for isoleucine at position 647 in comparison with the amino acid sequence of the wild-type AAV capsid protein. Specifically, when delivered in an aerosol state through the trachea, the recombinant virus vector carrying a nucleic acid coding for the mutant of the AAV1 capsid protein enhances transgene expression in pulmonary vessel targeting cells and thus is useful for preventing or treating pulmonary arterial hypertension.
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公开(公告)号：EP4458825A1
公开(公告)日：2024-11-06
申请号：EP22914529.7
申请日：2022-12-23
发明人： XI, Ning , LI, Xiaobo , LI, Minxiong , FENG, Xuejin
IPC分类号： C07D413/14 , A61K31/517 , A61P11/00 , A61P31/12 , A61P9/10 , A61P35/02 , A61P37/00
摘要： Provided are a salt of an aminopyrimidine compound and a use thereof. Specifically, provided are a salt of ( S )-2-(1-((6-amino-5-(3-methyl-1,2,4-oxadiazol-5-yl)pyrimidin-4-yl)amino)ethyl)-5-(3-hydroxypro p-1-yn-1-yl)-3-phenylquinazolin-4(3 H )-one and a pharmaceutical composition comprising the salt. Further provided is a use thereof in the preparation of a medicament for treating and preventing diseases related to PI3K kinase abnormalities.
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公开(公告)号：EP4400172A3
公开(公告)日：2024-11-06
申请号：EP24165623.0
申请日：2011-03-09
发明人： HUANG, Taisheng , XUE, Chu-Biao , WANG, Anlai , KONG, Ling , YE, Hai Fen , YAO, Wenqing , RODGERS, James D. , SHEPARD, Stacey , WANG, Haisheng , SHAO, Lixin , LI, Hui-Yin , LI, Qun
IPC分类号： A61K31/437 , A61K31/519 , A61P3/10 , A61P11/00 , A61P11/06 , A61P17/00 , A61P19/02 , A61P29/00 , A61P35/00
摘要： The present invention provides piperidin-4-yl azetidine derivatives, as well as their compositions and methods of use, that modulate the activity of Janus kinase 1 (JAK1) and are useful in the treatment of diseases related to the activity of JAK1 including, for example, inflammatory disorders, autoimmune disorders, cancer, and other diseases.
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公开(公告)号：EP3436040B1
公开(公告)日：2024-11-06
申请号：EP17773198.1
申请日：2017-03-28
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公开(公告)号：EP4452966A1
公开(公告)日：2024-10-30
申请号：EP22908911.5
申请日：2022-12-22
发明人： BRZOZOWSKI, Martin , GARNIER, Jean-Marc Daniel , GARDNER, Christopher , LESSENE, Guillaume Laurent , KERSTEN, Wilhelmus Johannes Antonius
IPC分类号： C07D401/14 , C07D417/14 , A61K31/437 , A61K31/4545 , A61K31/513 , A61K47/55 , A61P1/00 , A61P11/00 , A61P19/00 , A61P21/00 , A61P25/00 , A61P29/00 , A61P31/00 , A61P35/00 , A61P37/00 , A61P43/00 , A61P9/00
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公开(公告)号：EP4452272A1
公开(公告)日：2024-10-30
申请号：EP22911443.4
申请日：2022-12-23
申请人： Astellas Pharma Inc.
发明人： NAGASHIMA, Takeyuki
IPC分类号： A61K31/517 , A61P1/00 , A61P11/00 , A61P35/00
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9.发明公开
公开(公告)号：EP4452264A1
公开(公告)日：2024-10-30
申请号：EP22840711.0
申请日：2022-12-20
发明人： DELBECK, Martina , HAHN, Michael
IPC分类号： A61K31/437 , A61K31/4995 , A61K31/505 , A61K31/506 , A61K31/519 , A61K31/537 , A61K31/5377 , A61K31/5383 , A61K31/5386 , A61P11/00 , A61P25/20 , A61K31/138 , A61K45/06
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公开(公告)号：EP4452219A2
公开(公告)日：2024-10-30
申请号：EP22838922.7
申请日：2022-12-20
申请人： ConvaTec Limited
发明人： MUNRO, Hugh Semple , BOOTE, Nick , HORNER, Alan
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