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公开(公告)号：EP4400172A3
公开(公告)日：2024-11-06
申请号：EP24165623.0
申请日：2011-03-09
发明人： HUANG, Taisheng , XUE, Chu-Biao , WANG, Anlai , KONG, Ling , YE, Hai Fen , YAO, Wenqing , RODGERS, James D. , SHEPARD, Stacey , WANG, Haisheng , SHAO, Lixin , LI, Hui-Yin , LI, Qun
IPC分类号： A61K31/437 , A61K31/519 , A61P3/10 , A61P11/00 , A61P11/06 , A61P17/00 , A61P19/02 , A61P29/00 , A61P35/00
摘要： The present invention provides piperidin-4-yl azetidine derivatives, as well as their compositions and methods of use, that modulate the activity of Janus kinase 1 (JAK1) and are useful in the treatment of diseases related to the activity of JAK1 including, for example, inflammatory disorders, autoimmune disorders, cancer, and other diseases.
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公开(公告)号：EP4400172A2
公开(公告)日：2024-07-17
申请号：EP24165623.0
申请日：2011-03-09
发明人： HUANG, Taisheng , XUE, Chu-Biao , WANG, Anlai , KONG, Ling , YE, Hai Fen , YAO, Wenqing , RODGERS, James D. , SHEPARD, Stacey , WANG, Haisheng , SHAO, Lixin , LI, Hui-Yin , LI, Qun
IPC分类号： A61P27/02
CPC分类号： C07B2200/1320130101 , C07D487/04 , C07D519/00 , A61K31/4545 , A61K31/519 , A61P27/02
摘要： The present invention provides piperidin-4-yl azetidine derivatives, as well as their compositions and methods of use, that modulate the activity of Janus kinase 1 (JAK1) and are useful in the treatment of diseases related to the activity of JAK1 including, for example, inflammatory disorders, autoimmune disorders, cancer, and other diseases.
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公开(公告)号：EP4036088A1
公开(公告)日：2022-08-03
申请号：EP21213769.9
申请日：2011-03-09
发明人： HUANG, Taisheng , XUE, Chu-Biao , WANG, Anlai , KONG, Ling , YE, Hai Fen , YAO, Wenqing , RODGERS, James D. , SHEPARD, Stacey , WANG, Haisheng , SHAO, Lixin , LI, Hui-Yin , LI, Qun
IPC分类号： C07D401/14 , C07D405/14 , A61K31/4155 , A61K31/437 , A61K31/4468 , A61P27/02
摘要： The present invention provides piperidin-4-yl azetidine derivatives, as well as their compositions and methods of use, that modulate the activity of Janus kinase 1 (JAK1) and are useful in the treatment of diseases related to the activity of JAK1 including, for example, inflammatory disorders, autoimmune disorders, cancer, and other diseases.
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公开(公告)号：EP3715347A1
公开(公告)日：2020-09-30
申请号：EP20158754.0
申请日：2011-03-09
发明人： HUANG, Taisheng , XUE, Chu-Biao , WANG, Anlai , KONG, Ling , YE, Hai Fen , YAO, Wenqing , RODGERS, James D. , SHEPARD, Stacey , WANG, Haisheng , SHAO, Lixin , LI, Hui-Yin , LI, Qun
IPC分类号： C07D471/04 , C07D487/04 , A61K31/437 , A61K31/519 , A61P35/00
摘要： The present invention provides the use of piperidin-4-yl azetidine derivatives I in combination with an EGFR inhibitor to treat cancer.
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5.发明公开
公开(公告)号：EP3050882A1
公开(公告)日：2016-08-03
申请号：EP15195698.4
申请日：2011-03-09
发明人： HUANG, Taisheng , XUE, Chu-Biao , WANG, Anlai , KONG, Ling , YE, Hai Fen , YAO, Wenqing , RODGERS, James D. , SHEPARD, Stacey , WANG, Haisheng , SHAO, Lixin , LI, Hui-Yin , LI, Qun
IPC分类号： C07D471/04 , C07D487/04 , A61K31/437 , A61K31/519 , A61P3/10 , A61P17/00 , A61P19/02 , A61P29/00 , A61P35/00
CPC分类号： A61K31/4545 , A61K9/0014 , A61K9/0019 , A61K9/0024 , A61K9/0048 , A61K31/519 , A61P1/00 , A61P11/00 , A61P11/06 , A61P27/02 , A61P35/00 , C07B2200/13 , C07D401/14 , C07D405/14 , C07D471/04 , C07D487/04 , C07D519/00
摘要： The present invention provides piperidin-4-yl azetidine derivatives, as well as their compositions and methods of use, that modulate the activity of Janus kinase 1 (JAK1) and are useful in the treatment of diseases related to the activity of JAK1 including, for example, inflammatory disorders, autoimmune disorders, cancer, and other diseases.
摘要翻译： 本发明提供哌啶-4-基氮杂环丁烷衍生物及其组合物和使用方法，其调节Janus激酶1（JAK1）的活性，并且可用于治疗与JAK1的活性相关的疾病，包括对于 例如炎症性疾病，自身免疫性疾病，癌症和其它疾病。
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公开(公告)号：EP3354652B1
公开(公告)日：2020-05-06
申请号：EP17211097.5
申请日：2011-03-09
发明人： HUANG, Taisheng , XUE, Chu-Biao , WANG, Anlai , KONG, Ling , YE, Hai Fen , YAO, Wenqing , RODGERS, James D. , SHEPARD, Stacey , WANG, Haisheng , SHAO, Lixin , LI, Hui-Yin , LI, Qun
IPC分类号： C07D487/04 , A61K31/519 , A61P1/00 , A61P11/00 , A61P11/06 , A61P27/02 , A61P35/00
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公开(公告)号：EP3050882B1
公开(公告)日：2018-01-31
申请号：EP15195698.4
申请日：2011-03-09
发明人： HUANG, Taisheng , XUE, Chu-Biao , WANG, Anlai , KONG, Ling , YE, Hai Fen , YAO, Wenqing , RODGERS, James D. , SHEPARD, Stacey , WANG, Haisheng , SHAO, Lixin , LI, Hui-Yin , LI, Qun
IPC分类号： C07D471/04 , C07D487/04 , A61K31/437 , A61K31/519 , A61P3/10 , A61P17/00 , A61P19/02 , A61P29/00 , A61P35/00
CPC分类号： A61K31/4545 , A61K9/0014 , A61K9/0019 , A61K9/0024 , A61K9/0048 , A61K31/519 , A61P1/00 , A61P11/00 , A61P11/06 , A61P27/02 , A61P35/00 , C07B2200/13 , C07D401/14 , C07D405/14 , C07D471/04 , C07D487/04 , C07D519/00
摘要： The present invention provides piperidin-4-yl azetidine derivatives, as well as their compositions and methods of use, that modulate the activity of Janus kinase 1 (JAK1) and are useful in the treatment of diseases related to the activity of JAK1 including, for example, inflammatory disorders, autoimmune disorders, cancer, and other diseases.
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公开(公告)号：EP2545045B1
公开(公告)日：2016-01-06
申请号：EP11711709.3
申请日：2011-03-09
发明人： HUANG, Taisheng , XUE, Chu-Biao , WANG, Anlai , KONG, Ling , YE, Hai Fen , YAO, Wenqing , RODGERS, James D. , SHEPARD, Stacey , WANG, Haisheng , SHAO, Lixin , LI, Hui-Yin , LI, Qun
IPC分类号： C07D401/14 , C07D405/14 , A61K31/4155 , A61K31/437 , A61K31/4468 , A61P29/00
CPC分类号： A61K31/4545 , A61K9/0014 , A61K9/0019 , A61K9/0024 , A61K9/0048 , A61K31/519 , A61P1/00 , A61P11/00 , A61P11/06 , A61P27/02 , A61P35/00 , C07B2200/13 , C07D401/14 , C07D405/14 , C07D471/04 , C07D487/04 , C07D519/00
摘要： The present invention provides piperidin-4-yl azetidine derivatives, as well as their compositions and methods of use, that modulate the activity of Janus kinase 1 (JAK1) and are useful in the treatment of diseases related to the activity of JAK1 including, for example, inflammatory disorders, autoimmune disorders, cancer, and other diseases.
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公开(公告)号：EP3354652A1
公开(公告)日：2018-08-01
申请号：EP17211097.5
申请日：2011-03-09
发明人： HUANG, Taisheng , XUE, Chu-Biao , WANG, Anlai , KONG, Ling , YE, Hai Fen , YAO, Wenqing , RODGERS, James D. , SHEPARD, Stacey , WANG, Haisheng , SHAO, Lixin , LI, Hui-Yin , LI, Qun
IPC分类号： C07D487/04 , A61K31/519 , A61P1/00 , A61P11/00 , A61P11/06 , A61P27/02 , A61P35/00
摘要： The present invention provides piperidin-4-yl azetidine derivative, shown below, (or the adipc acid salt thereof) which modulates the activity of Janus kinase 1 (JAK1) and is useful in the treatment of diseases related to the activity of JAK1 including, for example, inflammatory disorders, autoimmune disorders, cancer, and other diseases.
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