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1.发明公开DISUBSTITUTED LAVENDUSTIN A ANALOGS AND PHARMACEUTICAL COMPOSITIONS COMPRISING THE ANALOGS 审中-公开脱氧核糖核酸酶ANALOGEN UND DIESE ENTHALTENDE PHARMAZEUTISCHE ZUSAMMENSETZUNGEN
公开(公告)号：EP1060160A2
公开(公告)日：2000-12-20
申请号：EP99910987.9
申请日：1999-02-24
IPC分类号： C07C229/60 , A61K31/195 , C07C69/94 , C07C69/95 , C07C65/19 , C07C229/64 , C07C237/30 , C07C225/28 , C07C225/22 , C07C215/68 , C07F9/38
CPC分类号： C07C229/60 , C07C69/94 , C07C69/95 , C07C215/68 , C07C225/22 , C07C225/24 , C07C229/64 , C07C237/30 , C07C2603/74 , C07F9/4021
摘要： Disubstituted lavendustin A analogs that are PTK inhibitors having antiproliferative activity are described. Preferred compounds of the present invention, without limitation, satisfy either Formula (1) or Formula (2). Currently preferred compounds, based on in vivo biological activity, are 4'-adamantylbenzoate-1'-N-1,4-dihydroxybenzylamine and 4'-adamantylmethylbenzoate-1'-N-1,4-dihydroxybenzylamine. The present invention also provides pharmaceutical compositions comprising effective amounts of disubstituted lavendustin A analogs. Such compositions also may comprise other active ingredients, other materials conventionally used in the formulation of pharmaceutical compositions, and mixtures thereof. The compounds and compositions of the present invention can be used for treating subjects to, for example, inhibit the proliferation of living cells in the treatment of proliferative diseases.
摘要翻译： 二取代的天冬氨酸蛋白酶A是具有抗增殖活性的PTK抑制剂的类似物。 本发明优选的化合物，但不限于式1或式2。目前优选的化合物基于体内生物学活性是4'-金刚烷基苯甲酸酯-1'-N-1,4-二羟基苄胺和4'-金刚烷基甲基苯甲酸酯 -1'- N-1,4-二羟基苄胺。 本发明还提供包含有效量的二取代的天冬胰蛋白酶A类似物的药物组合物。 这样的组合物还可以包含其它活性成分，药物组合物制剂中常规使用的其它材料及其混合物。 本发明的化合物和组合物可用于治疗受试者，例如抑制活细胞在增殖性疾病的治疗中的增殖。
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2.发明授权AZOMETHINE DIRECT DYES OR REDUCED PRECURSORS OF THESE DYES OBTAINED FROM 2-CHLORO-3-AMINO-6-METHYLPHENOL, AND HAIR DYEING METHOD STARTING FROM THESE DYES AND PRECURSORS 有权偶氮甲碱直接染料或减少这些染料前体，从2-氯-3-氨基-6-甲基苯酚和这些染料和前体OUTBOUND染发
公开(公告)号：EP2229140B1
公开(公告)日：2011-08-03
申请号：EP08860954.0
申请日：2008-12-09
申请人： L'Oréal
IPC分类号： A61K8/49 , A61Q5/10 , C09B53/02 , C07C225/28
CPC分类号： C07C251/22 , A61K8/413 , A61K8/415 , A61K8/4913 , A61K8/4946 , A61Q5/065 , A61Q5/10 , C07C215/82 , C07C2601/16 , C07D207/14 , C07D233/58 , C07D233/61 , C07D403/04 , C09B53/00
摘要： The invention relates to the dyeing of keratinous fibres using azomethine direct dyes of formula (I) or reduced precursors of azomethine direct dyes of formula (II) obtained from 2-chloro-3-amino-6-methylphenol. A subject-matter of the invention is a dyeing composition comprising at least one chlorinated azomethine direct dye or one reduced precursor of a chlorinated azomethine direct dye, a method for dyeing keratinous fibres which employs the said composition and their uses in the dyeing of keratinous fibres. This composition makes it possible to obtain a particularly stable and consistent colouring.
摘要翻译： 本发明涉及角蛋白纤维的使用（I）或降低的，从2-氯-3-氨基-6-甲基苯酚获得的式（II）的偶氮甲碱直接染料的前体的式偶氮甲碱直接染料染色。 本发明的主题是一种染色组合物，其包含至少一种氯化偶氮甲碱直接染料或氯化偶氮甲碱直接染料的一个减少前体，用于染色角蛋白纤维的方法，其采用了所述组合物和它们的用途在角质纤维的染色 ， 这种组合物使得有可能获得特别稳定的和一致的着色。
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3.发明公开2,5-BIS-DIAMINE-[1,4] BENZOQUINONE DERIVATIVES FOR THE TREATMENT OF ALZHEIMER'S DISEASE, A PROCESS FOR THEIR PREPARATION AND INTERMEDIATES THEREFOR 审中-公开2,5-双 - 二胺 - [1,4] BENZ CHINON衍生物用于治疗阿尔茨海默病，METHOD FOR PRODUCTION WHICH及其中间体的治疗
公开(公告)号：EP1497257A1
公开(公告)日：2005-01-19
申请号：EP03720875.8
申请日：2003-04-11
发明人： ANDRISANO, Vincenza , BARTOLINI, Manuela , BOLOGNESI, Maria, Laura , CAVALLI, Andrea , MELCHIORRE, Carlo , RECANATINI, Maurizio
IPC分类号： C07C225/28 , C07C221/00 , A61P25/28
CPC分类号： C07D307/52 , C07C225/28
摘要： 2,5-bis-diamine-[1,4]benzoquinonic derivatives, having a general formula (I) have proved useful for the treatment of Alzheimer's disease; a method for preparing them and intermediates used in said method are also described. Fomula (I).
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公开(公告)号：EP3131874B1
公开(公告)日：2018-07-25
申请号：EP14723345.6
申请日：2014-04-16
IPC分类号： C07C69/75 , C07C225/28
CPC分类号： C07C225/28 , C07B2200/07 , C07C69/95 , C07C2601/16 , C07C2602/42
摘要： The present invention relates to novel cannabidiol quinone derivatives of formula (I) (I) wherein R is the carbon atom of a, linear or branched group, represented by: alkyl, aryl, alkenyl, alkynyl, acyl or alkoxycarbonyl groups; or wherein R is the nitrogen atom of a, linear or branched group represented by: alkylamine, arylamine, alkenylamineor alkynylamine groups. The invention also relates to the use of any of the compounds of formula (I)as medicamentsin therapy, particularly for treating diseasesand conditions responsive to PPARg modulationdue to their high PPARg agonistic effect lacking electrophilic (Nrf2 activation) and cytotoxic activities. This invention also provides pharmaceutical compositions comprising said compounds and method of treating diseases with said compounds.
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公开(公告)号：EP3131874A1
公开(公告)日：2017-02-22
申请号：EP14723345.6
申请日：2014-04-16
IPC分类号： C07C69/75 , C07C225/28
CPC分类号： C07C225/28 , C07B2200/07 , C07C69/95 , C07C2601/16 , C07C2602/42
摘要： The present invention relates to novel cannabidiol quinone derivatives of formula (I) (I) wherein R is the carbon atom of a, linear or branched group, represented by: alkyl, aryl, alkenyl, alkynyl, acyl or alkoxycarbonyl groups; or wherein R is the nitrogen atom of a, linear or branched group represented by: alkylamine, arylamine, alkenylamineor alkynylamine groups. The invention also relates to the use of any of the compounds of formula (I)as medicamentsin therapy, particularly for treating diseasesand conditions responsive to PPARg modulationdue to their high PPARg agonistic effect lacking electrophilic (Nrf2 activation) and cytotoxic activities. This invention also provides pharmaceutical compositions comprising said compounds and method of treating diseases with said compounds.
摘要翻译： 本发明涉及式（I）（I）的新型大二酚醌衍生物，其中R是直链或支链基团的碳原子，由烷基，芳基，烯基，炔基，酰基或烷氧基羰基表示; 或其中R为直链或支链基团的氮原子，由：烷基胺，芳基胺，链烯基胺或炔基胺基团表示。 本发明还涉及任何式（I）化合物作为治疗药物的用途，特别是用于治疗对PPARg调节有反应的疾病和病症，这是由于它们的高PPARg激动作用缺乏亲电子（Nrf2活化）和细胞毒活性。 本发明还提供包含所述化合物的药物组合物和用所述化合物治疗疾病的方法。
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公开(公告)号：EP2913321A1
公开(公告)日：2015-09-02
申请号：EP14156954.1
申请日：2014-02-27
IPC分类号： C07C225/28 , C07C50/08 , C07C62/38
CPC分类号： C07C50/28 , A61K31/122 , A61K31/13 , A61K31/215 , C07C69/757 , C07C69/95 , C07C225/28 , C07C2601/14 , C07C2601/16
摘要： The present invention relates to novel cannabigerol quinone derivatives of formula (I)
wherein R is the carbon atom of a linear or branched group, represented by: alkyl, aryl, alkenyl, alkynyl, acyl, or alcoxycarbonil groups; or wherein R is the nitrogen atom of a linear or branched group, represented by: alkylamino, arylamino, alkenylamino or alkynylamino groups; or, alternatively, R represents a bond between 2 molecules of formula (I) forming a dimer. The invention also relates to the use of any of the compounds of formula (I) as medicaments in therapy, particularly for treating PPARg-related diseases due to their high PPARg agonistic effect lacking electrophilic (Nrf2 activation) and cytotoxic activities. This invention also provides pharmaceutical compositions comprising said compounds and method of treating diseases with said compounds.摘要翻译： 本发明涉及式（I）的新型大麻素醌衍生物，其中R为直链或支链基团的碳原子，由以下各项表示：烷基，芳基，烯基，炔基，酰基或烷氧基碳酰基; 或其中R是直链或支链基团的氮原子，由以下基团表示：烷基氨基，芳基氨基，烯基氨基或炔基氨基; 或者，或者，R代表形成二聚体的2个式（I）分子之间的键。 本发明还涉及式（I）的任何化合物作为药物在治疗中的应用，特别是用于治疗PPARg相关疾病，因为它们具有缺乏亲电子（Nrf2激活）和细胞毒性活性的高PPARg激动作用。 本发明还提供了包含所述化合物的药物组合物和用所述化合物治疗疾病的方法。
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7.发明公开AZOMETHINE DIRECT DYES OR REDUCED PRECURSORS OF THESE DYES OBTAINED FROM 2-CHLORO-3-AMINO-6-METHYLPHENOL, AND HAIR DYEING METHOD STARTING FROM THESE DYES AND PRECURSORS 有权偶氮甲碱直接染料或减少这些染料前体，从2-氯-3-氨基-6-甲基苯酚和这些染料和前体OUTBOUND染发
公开(公告)号：EP2229140A1
公开(公告)日：2010-09-22
申请号：EP08860954.0
申请日：2008-12-09
申请人： L'Oréal
IPC分类号： A61K8/49 , A61Q5/10 , C09B53/02 , C07C225/28
CPC分类号： C07C251/22 , A61K8/413 , A61K8/415 , A61K8/4913 , A61K8/4946 , A61Q5/065 , A61Q5/10 , C07C215/82 , C07C2601/16 , C07D207/14 , C07D233/58 , C07D233/61 , C07D403/04 , C09B53/00
摘要： The invention relates to the dyeing of keratinous fibres using azomethine direct dyes of formula (I) or reduced precursors of azomethine direct dyes of formula (II) obtained from 2-chloro-3-amino-6-methylphenol. A subject-matter of the invention is a dyeing composition comprising at least one chlorinated azomethine direct dye or one reduced precursor of a chlorinated azomethine direct dye, a method for dyeing keratinous fibres which employs the said composition and their uses in the dyeing of keratinous fibres. This composition makes it possible to obtain a particularly stable and consistent colouring.
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8.发明授权FUEL AND LUBRICANT ADDITIVES DERIVED FROM DIHYDROXYAROMATIC COMPOUNDS 失效作者羟基芳族化合物HERKOMMENDE FUEL和油脂配件
公开(公告)号：EP0722464B1
公开(公告)日：1998-02-04
申请号：EP94929986.1
申请日：1994-09-30
IPC分类号： C08F8/32 , C10L1/22 , C10M133/54 , C10M133/12 , C07C225/28 , C10M159/12
CPC分类号： C07D295/13 , C07C225/20 , C07C225/28 , C07C225/30 , C10L1/22 , C10L1/223 , C10L1/2235 , C10L1/232 , C10L1/238 , C10L1/2383 , C10L1/2387 , C10L10/04 , C10L10/08 , C10M129/14 , C10M133/06 , C10M133/54 , C10M159/12 , C10M2207/024 , C10M2215/04 , C10M2215/042 , C10M2215/26 , C10M2217/046 , C10M2217/06 , C10M2227/00 , C10M2227/061 , C10N2240/00 , C10N2240/02 , C10N2240/08 , C10N2240/10 , C10N2240/101 , C10N2240/102 , C10N2240/103 , C10N2240/104 , C10N2240/106 , C10N2240/22 , C10N2240/30 , C10N2240/50 , C10N2240/52 , C10N2240/54 , C10N2240/56 , C10N2240/58 , C10N2240/60 , C10N2240/66
摘要： The present invention relates to a novel process for the production of fuel and lubricant additives useful as dispersants and multifunctional viscosity modifiers wherein a dihydroxyaromatic compound is alkylated with an olefinic polymer and then aminated in such a manner as to oxidize the hydroxyl moieties of the dihydroxyaromatic compound to carbonyl groups.
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9.发明公开
公开(公告)号：EP3921300A1
公开(公告)日：2021-12-15
申请号：EP20753058.5
申请日：2020-02-06
IPC分类号： C07C225/28 , A61K31/133
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公开(公告)号：EP1890995A2
公开(公告)日：2008-02-27
申请号：EP06765510.0
申请日：2006-06-13
IPC分类号： C07C225/28 , C07C221/00 , A61K31/132 , A61P25/28
CPC分类号： C07C225/28 , C07D213/38 , C07D333/20
摘要： Synthesis of 2,5-bis-diamine-[l,4]benzoquinonic derivatives having the general formula (I), products and intermediates of said synthesis; the synthesis involves the use of p-benzoquinones having the general formula (IX) and diamines having the general formula (XI).
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