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    AZEOTROPIC DISTILLATION OF CYCLIC ESTERS OF HYDROXY ORGANIC ACIDS
    4.
    发明公开
    AZEOTROPIC DISTILLATION OF CYCLIC ESTERS OF HYDROXY ORGANIC ACIDS 有权
    含羟基有机酸的环状酯的共沸蒸馏

    公开(公告)号：EP1412043A2

    公开(公告)日：2004-04-28

    申请号：EP02778185.5

    申请日：2002-03-06

    申请人： A.E. STALEY MANUFACTURING COMPANY

    发明人： COCKREM, Michael, Charles, Milner ,  KOVACS, Istvan

    IPC分类号： B01D3/10 ,  B01D3/16 ,  B01D3/36 ,  B01D3/38 ,  C07C51/46 ,  C07C51/48 ,  C07C59/06 ,  C07C59/08 ,  C07C59/10 ,  C07C69/68

    CPC分类号： C07C51/46 ,  B01D3/36 ,  C07C51/42 ,  C07C59/06 ,  C07C59/08

    摘要： Cyclic esters of hydroxy organic acids can be produced and recovered via azeotropic distillation. In certain embodiments, cyclic esters such as glycolide and lactide can be produced from a fermentation broth or other feedstream that comprises a hydroxy organic acid, an ammonium salt of a hydroxy organic acid, or an ester of a hydroxy organic acid using azeotropic distillation. The hydroxy organic acid for the feedstream or the organic acid derived from the feedstream by decomposition is related to produce the cyclic ester. In other embodiments a crude composition of a cyclic ester of an organic ester can be purified using azeotropic distillation. The feedstream (10) and an azeotroping agent (12) are mixed in a reactor (14). A first vapor stream (20) can be purified using a first column (22), a second column (27) and a separator (38). A first column bottoms stream (24) from the first column (22) can be recycled back to reactor (14).

    摘要翻译： 羟基有机酸的环酯可以通过共沸蒸馏生产和回收。 在某些实施方案中，环状酯如乙交酯和丙交酯可以使用共沸蒸馏由包含羟基有机酸，羟基有机酸的铵盐或羟基有机酸的酯的发酵液或其他进料流产生。 进料流的羟基有机酸或通过分解从进料流得到的有机酸涉及产生环酯。 在其他实施方案中，可以使用共沸蒸馏来纯化有机酯的环状酯的粗制组合物。 进料流（10）和共沸剂（12）在反应器（14）中混合。 可以使用第一塔（22），第二塔（27）和分离器（38）来纯化第一蒸气流（20）。 来自第一塔（22）的第一塔底物流（24）可以再循环回反应器（14）。

    PREPARATION OF OPTICALLY ACTIVE 1,3-DIOXOLANE-4-METHANOL COMPOUNDS.
    9.
    发明公开
    PREPARATION OF OPTICALLY ACTIVE 1,3-DIOXOLANE-4-METHANOL COMPOUNDS. 失效
    光学活性的1,3-二氧戊环-4-甲醇的连接的生产。

    公开(公告)号：EP0173714A4

    公开(公告)日：1986-07-24

    申请号：EP85901208

    申请日：1985-02-11

    申请人： AMERICAN HOSPITAL SUPPLY CORP

    发明人： MAI KHUONG H X ,  PATIL GHANSHYAM

    IPC分类号： C07C69/675 ,  B01J31/00 ,  B01J31/04 ,  C07C51/00 ,  C07C51/367 ,  C07C59/10 ,  C07C67/00 ,  C07C67/08 ,  C07D317/20 ,  C07D317/72 ,  C07C59/285

    CPC分类号： C07D317/72 ,  C07C59/10 ,  C07D317/20

    摘要： Process for preparing 2,2'-disubstituted-1,3-dioxolane-4-methanol compounds having formula (I), wherein R1 and R2 are each independently hydrogen, alkyl, cycloalkyl or R1 and R2 together with the carbon atom form a 3 to 6 member cycloalkyl group, or aryl, the process comprising: reacting D- or L-serine with a nitrosating agent in an aqueous solution in the presence of formic acid, acetic acid, or propanoic acid to prepare 2,3-dihydroxypropanoic acid (D- or L-glyceric acid), the aqueous solution comprising from about 0.1 to 0.5 liter of water per mole of the serine starting material; reacting the glyceric acid so formed with 2,2-dimethoxypropane in the presence of a loweralkyl alcohol to prepare the D- or L-glyceric acid alkyl ester which is reacted with a selected aldehyde or ketone or the acetal or ketal derivative to prepare the corresponding 1,3-dioxolane derivative. Reacting the 1,3-dioxolane derivative with lithium aluminum hydride provides the desired 2,2'-disubstituted-1,3-dioxolane-4-methanol derivative. If an alcohol is not used as described above, then the 2,3-dihydroxy-propanoic acid is reacted with a selected aldehyde or ketone or the acetal or ketal derivative to prepare the 1,3-dioxolane derivative. The dioxolane derivative is then reacted with lithium aluminum hydride to provide the desired 2,2'-disubstituted-1,3-dioxolane-4-methanol derivative. The compounds so prepared are intermediates in the preparation of optically active beta-agonists or antagonists.