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公开(公告)号：EP2102210A2
公开(公告)日：2009-09-23
申请号：EP07862967.2
申请日：2007-12-14
IPC分类号： C07D475/12
CPC分类号： C07D475/00
摘要： The present invention relates to compounds useful as inhibitors of protein kinase. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders. The invention also provides processes for preparing compounds of the inventions.
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公开(公告)号：EP3747866B1
公开(公告)日：2023-03-01
申请号：EP19747114.7
申请日：2019-01-30
发明人： XU, Heng , CHEN, Xiaoguang , LIN, Songwen , JI, Ming , XUE, Nina , WU, Deyu , JIN, Jing
IPC分类号： C07D213/32 , C07D213/40 , C07D213/71 , C07D401/12 , C07D405/02 , C07D405/12 , C07D407/12 , C07D409/12 , C07D475/12 , A61K31/18 , A61K31/435 , A61K31/4355 , A61K31/436 , A61K31/4427 , A61P25/00 , A61P29/00 , A61P35/00 , A61P37/02
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公开(公告)号：EP2364314B1
公开(公告)日：2014-03-12
申请号：EP09775438.6
申请日：2009-12-07
发明人： DESAI, Manoj, C. , HALCOMB, Randall, L. , HRVATIN, Paul , HUI, Hon Chung , MC FADDEN, Ryan , ROETHLE, Paul, A. , YANG, Hong
IPC分类号： C07D475/06 , C07D475/08 , C07D475/12 , C07D487/04 , A61K31/519 , A61P31/12 , A61P35/00
CPC分类号： A61K31/519 , A61K31/527 , A61K31/5377 , A61K31/551 , A61K31/573 , A61K31/683 , A61K31/7056 , A61K31/7072 , A61K31/708 , A61K38/16 , A61K38/21 , A61K38/212 , A61K45/06 , C07D403/12 , C07D475/06 , C07D475/08 , C07D475/10 , C07D475/12 , C07D487/04 , Y02A50/385 , Y02A50/387 , Y02A50/389 , Y02A50/391 , Y02A50/393 , Y02A50/395
摘要： Provided are intermediates for the production of modulators of toll-like receptors with the following structures:
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公开(公告)号：EP2958919B1
公开(公告)日：2019-05-22
申请号：EP13705185.0
申请日：2013-02-21
IPC分类号： C07D475/00 , C07D475/12 , A61K31/519
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公开(公告)号：EP2958918B1
公开(公告)日：2016-12-07
申请号：EP13704969.8
申请日：2013-02-21
IPC分类号： C07D475/00 , C07D475/12 , A61K31/519
CPC分类号： C07D491/20 , C07D475/00 , C07D475/12
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6.发明授权COMPOSITIONS AND METHODS OF REDUCING SIDE EFFECTS AND TOXICITY OF METHOTREXATE WHEN GIVEN AS OROTATE DERIVATIVES 有权组合物和方法减少副作用和甲氨蝶呤毒性总局评为乳清酸衍生物
公开(公告)号：EP2104502B1
公开(公告)日：2015-05-06
申请号：EP08713200.7
申请日：2008-01-18
申请人： Savvipharm Inc.
发明人： KARMALI, Rashida, A.
IPC分类号： A61K31/525 , C07D475/12 , A61P35/00
CPC分类号： A61K31/525 , C07D487/04
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公开(公告)号：EP4392423A1
公开(公告)日：2024-07-03
申请号：EP22861983.9
申请日：2022-08-23
发明人： YAN, Shunqi , YEH, Litain
IPC分类号： C07D451/14 , C07D475/12 , C07D491/048 , C07D498/14 , A61K31/517 , A61K31/519 , A61K31/5377 , A61P35/00 , C07D239/94 , C07D401/04 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/14 , C07D405/12 , C07D405/14 , C07D413/14 , C07D417/14
CPC分类号： A61P35/00 , C07D401/12 , C07D401/14 , C07D403/04 , C07D405/14 , C07D401/04 , C07D413/14 , C07D417/14 , C07D487/04 , C07D403/12 , C07D471/08 , C07D498/04
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公开(公告)号：EP2958919A1
公开(公告)日：2015-12-30
申请号：EP13705185.0
申请日：2013-02-21
IPC分类号： C07D475/00 , C07D475/12 , A61K31/519
CPC分类号： C07D487/14 , C07D471/14 , C07D475/00 , C07D475/12 , C07D498/14
摘要： The present invention relates to dihydropteridinones, their use as modulators of γ-secretase and to pharmaceutical compositions containing said compounds. In particular, the present invention relates to compounds which interfere with γ-secretase and/or its substrate and therefore modulate the formation of Αβ peptides.
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公开(公告)号：EP2516441A1
公开(公告)日：2012-10-31
申请号：EP10798439.5
申请日：2010-12-21
发明人： GALEMMO, Robert, A., Jr. , ARTIS, Dean Richard , YE, Xiaocong Michael , AUBELE, Danielle, L. , TRUONG, Anh, P. , BOWERS, Simeon , HOM, Roy, K. , ZHU, Yong-Liang , NEITZ, R., Jeffrey , SEALY, Jennifer , ADLER, Marc , BEROZA, Paul , ANDERSON, John, P.
IPC分类号： C07D475/04 , C07D475/12 , A61K31/4985 , A61P25/00
CPC分类号： C07D475/00 , A61K31/519 , A61K31/5377 , A61K31/5383 , C07D475/04 , C07D475/12 , C07D487/14 , C07D498/14 , C07D519/00
摘要： The present invention provides compounds having a structure according to Formula (I): or a salt or solvate thereof, wherein ring A, E1, E2, R1, R2, R3 and R4 are defined herein. The invention further provides pharmaceutical compositions including the compounds of the invention and methods of making and using the compounds and compositions of the invention, e.g., in the treatment and prevention of various disorders, such as Parkinson's disease.
摘要翻译： 本发明提供具有根据式（I）的结构的化合物或其盐或溶剂合物，其中环A，E1，E2，R1，R2，R3和R4如本文所定义。 本发明进一步提供了包含本发明化合物的药物组合物以及制备和使用本发明化合物和组合物的方法，例如用于治疗和预防各种病症如帕金森氏病。
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10.发明公开COMPOSITIONS AND METHODS OF REDUCING SIDE EFFECTS AND TOXICITY OF METHOTREXATE WHEN GIVEN AS OROTATE DERIVATIVES 有权组合物和方法减少副作用和甲氨蝶呤毒性总局评为乳清酸衍生物
公开(公告)号：EP2104502A4
公开(公告)日：2011-08-10
申请号：EP08713200
申请日：2008-01-18
申请人： SAVVIPHARM INC
发明人： KARMALI RASHIDA A
IPC分类号： A61K31/525 , A61P35/00 , C07D475/12
CPC分类号： A61K31/525 , C07D487/04
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