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    METHOD FOR INDUCING NEURONAL SYNAPSE FORMATION AND MICROBEADS USED IN SAID METHOD
    5.
    发明公开
    METHOD FOR INDUCING NEURONAL SYNAPSE FORMATION AND MICROBEADS USED IN SAID METHOD 审中-公开

    公开(公告)号：EP3995509A1

    公开(公告)日：2022-05-11

    申请号：EP20837110.4

    申请日：2020-06-26

    申请人： Jiksak Bioengineering, Inc.

    发明人： YUMOTO Norihiro ,  KAWADA Jiro

    IPC分类号： C07K14/705 ,  C07K16/00 ,  C07K17/06 ,  C07K19/00 ,  C12M1/00 ,  C12M3/00 ,  C12N5/0793

    摘要： An object of the present invention is to provide a method for inducing the formation of the presynaptic apparatus in human neurons.
    According to the present invention, a method for inducing the formation of the presynaptic apparatus in human neurons, comprising co-culturing the peripheral neurons with microbeads in which at least one LRRTM molecule selected from the group consisting of the LRRTM (Leucine-rich repeat transmembrane neuronal protein) family molecules or a fusion protein containing the same is fixed to the surface (wherein, the LRRTM molecule or the fusion protein containing the same molecule is fixed to the surface of the microbead via a linker), and a microbead used for the method, are provided.

    COMPOUND FOR THE PREVENTION OR TREATMENT OF MYASTHENIA GRAVIS
    9.
    发明公开
    COMPOUND FOR THE PREVENTION OR TREATMENT OF MYASTHENIA GRAVIS 审中-公开

    公开(公告)号：EP3715376A1

    公开(公告)日：2020-09-30

    申请号：EP19164786.6

    申请日：2019-03-23

    申请人： Ablevia biotech GmbH

    发明人： The designation of the inventor has not yet been filed

    IPC分类号： C07K17/06 ,  A61K39/00 ,  A61K47/54 ,  C07K14/705

    摘要： The present invention provides a compound for the sequestration of anti human muscle nicotinic acetylcholine receptor (AChR) antibodies present in a human individual, the compound comprising a biopolymer scaffold and at least two peptides with a sequence length of 7-13 amino acids, wherein each of the peptides independently comprises a 7-13 amino-acid sequence fragment of the AChR subunit alpha sequence identified by UniProt accession code P02708, wherein the peptides are covalently bound to the biopolymer scaffold, wherein the biopolymer scaffold is selected from the group consisting of human globulins and human albumin. This compound is useful in the prevention or treatment of myasthenia gravis.

    COMPOUND FOR THE SEQUESTRATION OF UNDESIRABLE ANTIBODIES IN A PATIENT
    10.
    发明公开
    COMPOUND FOR THE SEQUESTRATION OF UNDESIRABLE ANTIBODIES IN A PATIENT 审中-公开

    公开(公告)号：EP3715374A1

    公开(公告)日：2020-09-30

    申请号：EP19164784.1

    申请日：2019-03-23

    申请人： Ablevia biotech GmbH

    发明人： The designation of the inventor has not yet been filed

    IPC分类号： C07K17/06 ,  A61K39/00 ,  A61K47/54 ,  C07K14/05

    摘要： The present invention provides a compound for the sequestration of undesirable antibodies (e.g. related to an autoimmune disease) in a patient. The compound comprises an inert biopolymer scaffold and at least a first peptide n-mer of the general formula P ( - S - P ) (n-1) and a second peptide n-mer of the general formula P ( - S - P ) (n-1) ; wherein, independently for each occurrence, P is a peptide with a sequence length of 2-13 amino acids and S is a non-peptide spacer, wherein, independently for each of the peptide n-mers, n is an integer of at least 1, wherein each of the peptide n-mers is bound to the biopolymer scaffold. Also provided are pharmaceutical compositions comprising the compound, as well as a method of sequestering one or more antibodies present in an individual and a method of inhibiting an immune reaction to a treatment with an active agent.