利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

59 条记录 (耗时 0.029 秒)

    TREATMENT OF OPTIC NEURITIS
    6.
    发明公开
    TREATMENT OF OPTIC NEURITIS 审中-公开
    治疗视神经炎

    公开(公告)号：EP1933860A2

    公开(公告)日：2008-06-25

    申请号：EP06778410.8

    申请日：2006-08-30

    申请人： ARES TRADING S.A.

    发明人： SERGOTT, Robert

    IPC分类号： A61K38/21 ,  A61K31/56 ,  A61K38/35 ,  A61P25/00

    CPC分类号： A61K31/56 ,  A61K38/215 ,  A61K2300/00

    摘要： The present invention provides a method for treating a patient having demyelinating optic neuritis (DON) comprising the sequential or simultaneous administration of a steroid compound and an interferon-beta protein. It is found that early, aggressive treatment of IFN-b is beneficial in such a treatment regimen, for example where the interferon-beta protein is administered at a cumulative weekly dose of more than 12 MIL). The method according to the invention is particularly suitable and beneficial for treatment of patients having early stage DON. In particular, the DON that will benefit from being treated according to the present invention may be in subclinical stage.

    UROCORTIN PROTEINS AND USES THEREOF
    8.
    发明公开
    UROCORTIN PROTEINS AND USES THEREOF 有权
    UROCORTIN蛋白及其用途

    公开(公告)号：EP1305334A1

    公开(公告)日：2003-05-02

    申请号：EP01963759.4

    申请日：2001-07-31

    申请人： RESEARCH DEVELOPMENT FOUNDATION

    发明人： VALE, Wylie, W. ,  SAWCHENKO, Paul, F. ,  LEWIS, Kathy, A. ,  VAUGHAN, Joan, M. ,  REYES, Teresa, M. ,  RIVIER, Jean, E. ,  HOGENESCH, John, B. ,  PERRIN, Marilyn, H.

    IPC分类号： C07K14/435 ,  C07K14/47 ,  C07K14/575 ,  C07K14/695 ,  C07K16/26 ,  C12N5/10 ,  C12N15/12 ,  C12N15/16 ,  C12N15/62 ,  C12N15/63 ,  C12N15/64 ,  A61K38/16 ,  A61K38/17 ,  A61K38/22 ,  A61K38/35 ,  A61K39/395

    CPC分类号： C07K14/57509 ,  A61K38/00 ,  A61K39/00

    摘要： A human urocortin-related peptide with significant sequence homology to the CRF neuropeptide family was identified. A mouse cDNA was isolated from whole brain poly (A+) RNA that encodes a predicted 38 amino acid peptide protein designated herein as urocortin II. Both human URP and mouse family members, CRF and urocortin (Ucn). These peptides are involved in the regulation of the hypothalamic-pituitary-adrenal axis under basal and stress conditions, suggesting a similar role for URP and Ucn II. Synthesized Ucn-II and URP peptide binds with higher affinity to CRF-R2 than to CRF-R1 Ucn II and human URP appear to be involved in the regulation of body temperature and appetite and may play a role in other stress related phenomenon. These findings identify Ucn II and human URP as a new members of the CRF family of neuropeptides, which are expressed centrally and bind to CRF-R2.

    摘要翻译： 鉴定了与CRF神经肽家族具有显着序列同源性的人类urocortin相关肽。 从全脑多聚腺苷酸（A +）RNA中分离小鼠cDNA，其编码预测的38个氨基酸的肽蛋白质，在本文中称为尿皮质素II。 人类URP和小鼠家族成员，CRF和urocortin（Ucn）。 这些肽在基础和应激条件下参与下丘脑 - 垂体 - 肾上腺轴的调节，表明URP和Ucn II具有类似的作用。 合成的Ucn-II和URP肽以更高的亲和力与CRF-R2结合而不是与CRF-R1 Ucn II结合，并且人类URP似乎参与体温和食欲的调节并且可能在其他与应激有关的现象中起作用。 这些发现将Ucn II和人类URP鉴定为神经肽的CRF家族的新成员，所述神经肽集中表达并与CRF-R2结合。