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    ANTICOAGULATION AND ANTICALCIFICATION BIOLOGICAL MATERIAL, AND PREPARATION METHOD THEREFOR
    5.
    发明公开
    ANTICOAGULATION AND ANTICALCIFICATION BIOLOGICAL MATERIAL, AND PREPARATION METHOD THEREFOR 审中-公开

    公开(公告)号：EP4140511A1

    公开(公告)日：2023-03-01

    申请号：EP21792008.1

    申请日：2021-04-23

    申请人： Venus MedTech (HangZhou), Inc.

    发明人： WANG, Yunbing ,  YANG, Fan ,  GUO, Gaoyang

    IPC分类号： A61L27/36 ,  A61L27/24 ,  A61L33/00 ,  C08F289/00 ,  C08F220/60 ,  C08F220/36 ,  C08F230/02

    摘要： Provided are an anticoagulation and anticalcification biological material and a preparation method therefor. The preparation method includes the following steps: introducing, on a biological tissue, a polymerizable reactive group, and undergoing free radical copolymerization with a zwitterion. In the present invention, by introducing a reactive group capable of free radical polymerization to a biological tissue and undergoing free radical copolymerization with a zwitterionic monomer, collagen in the biological tissue is crosslinked at multiple sites by means of a polymer, thereby achieving sufficient crosslinking within and between collagen fibers, improving the stability of the biological tissue, and prolonging the service life of the biological tissue. Moreover, a zwitterion is introduced to the surface of the biological tissue, to improve the anticoagulation performance, promote the in-situ endothelialization of a biological valve, and prevent the calcium element deposition.

    COPOLYMER, METHOD FOR PRODUCING SAME, MEASUREMENT DEVICE, AND MEASUREMENT CARRIER
    6.
    发明公开
    COPOLYMER, METHOD FOR PRODUCING SAME, MEASUREMENT DEVICE, AND MEASUREMENT CARRIER 审中-公开

    公开(公告)号：EP4116340A1

    公开(公告)日：2023-01-11

    申请号：EP21764970.6

    申请日：2021-03-01

    申请人： Kyocera Corporation

    发明人： ANDO, Tsuyoshi ,  MURASE, Nobuo ,  KURIOKA, Hideharu

    IPC分类号： C08F8/00 ,  C08F220/36 ,  G01N29/02

    摘要： The copolymer of the present disclosure comprises a first structural unit represented by Formula (1) and a second structural unit represented by Formula (2). In Formula (1), R 1 is a hydrogen atom or a methyl group. R 2 and R 3 are each independently a hydrogen atom or an alkyl group having from 1 to 4 carbons. x1 is an integer of 1 to 4.
    In Formula (2), R 4 is a hydrogen atom or a methyl group. R 5 and R 6 are each independently a hydrogen atom or an alkyl group having from 1 to 4 carbons. x2 is an integer of 1 to 4, and y is an integer of 3 to 7.