公开(公告)号：EP3943919B1

公开(公告)日：2023-11-22

申请号：EP20773060.7

申请日：2020-03-18

发明人： YOSHIHARA, Toshitada ,  MARUYAMA, Ryo ,  TOBITA, Seiji

IPC分类号： C07D405/04 ,  C07D413/04 ,  C07D417/04 ,  C09B57/02 ,  G01N33/92

公开(公告)号：EP3314257B1

公开(公告)日：2021-06-16

申请号：EP16736957.8

申请日：2016-06-20

发明人： MELQUIST, Penny ,  GEE, Kyle

IPC分类号： G01N33/50 ,  G01N33/58 ,  C07D311/16 ,  C07D311/54 ,  C07F9/655 ,  C09B57/02

公开(公告)号：EP3126451B1

公开(公告)日：2020-09-09

申请号：EP15774408.7

申请日：2015-04-01

申请人： Howard Hughes Medical Institute

发明人： LAVIS, Luke, D. ,  GRIMM, Jonathan, B. ,  CHEN, Jiji ,  LIONETTE, Timothee ,  ZHANG, Zhengjian ,  REVYAKIN, Audrey ,  SLAUGHTER, Joel

IPC分类号： C09B57/02 ,  C07D311/06 ,  A61K31/37 ,  A61K31/397 ,  C09B57/14 ,  C07D405/04 ,  C07D413/04

公开(公告)号：EP3553136A1

公开(公告)日：2019-10-16

申请号：EP18754496.0

申请日：2018-02-13

申请人： Konica Minolta, Inc.

发明人： TAKANASHI Kensaku ,  NAKAYAMA Shin ,  NISHIKAWA Kenji ,  ISODA Takeshi

IPC分类号： C09B57/02 ,  C09K11/06 ,  G01N33/533

摘要： The present invention provides: an aminocoumarin compound having a structure represented by the following formula (1); and an aminocoumarin compound-containing resin particle containing the aminocoumarin compound and a resin particle containing the aminocoumarin compound. In formula (1), Rs each independently represent a hydrogen atom or a methyl group, Q represents a sulfur atom, an oxygen atom, or N-R 1 , and R 1 represents a hydrogen atom or a methyl group. The aminocoumarin compound of the present invention is a fluorescent dye that has a longer excitation wavelength than a conventionally known sulfonated coumarin-based compound and is effectively excited at a wavelength of 475 nm or more, particularly at a wavelength around 500 nm. The aminocoumarin compound of the present invention is a fluorescent dye that is excited, for example, at a wavelength of 475 to 510 nm and can be observed in a green light emission region of 510 to 540 nm using the wavelength characteristic, and can be expected to be suitably utilized in immunostaining or the like.

公开(公告)号：EP3196274B1

公开(公告)日：2019-03-06

申请号：EP16181401.7

申请日：2011-09-16

申请人： Etablissements J. Soufflet ,  Université de Strasbourg

发明人： DREVELLE, Antoine ,  LADAME, Sylvain ,  NAJAH, Majdi ,  MAYOT, Estelle

IPC分类号： C09K11/06 ,  C07H17/075 ,  C12Q1/34 ,  G01N21/64 ,  C07H17/04 ,  C09B57/02

公开(公告)号：EP3312292A1

公开(公告)日：2018-04-25

申请号：EP17186149.5

申请日：2006-05-31

申请人： Promega Corporation

发明人： Cali,, James J ,  Daily,, William ,  Hawkins,, Erika ,  Klaubert,, Dieter ,  Liu,, Jianquan ,  Meisenheimer,, Poncho ,  Scurria,, Michael ,  Schultz,, John W ,  Unch,, James ,  Wood,, Keith V ,  Zhou,, Wenhui ,  Valley,, Michael P

IPC分类号： C12Q1/66 ,  C07D277/66 ,  C07D277/68 ,  C07D311/16 ,  C07D417/14 ,  C07D493/10 ,  C07F9/6558 ,  C09B11/24 ,  C09B19/00 ,  C09B57/00 ,  C09B57/02

CPC分类号： C07D277/66 ,  C07D277/68 ,  C07D311/16 ,  C07D417/04 ,  C07D417/14 ,  C07D493/10 ,  C07F9/65583 ,  C09B11/24 ,  C09B19/00 ,  C09B57/00 ,  C09B57/02 ,  C12Q1/66 ,  G01N2500/00

摘要： A method to detect the presence or amount of at least one molecule in a sample which employs a derivative of luciferin or a derivative of a fluorophore is provided.

摘要翻译： 提供了检测采用荧光素衍生物或荧光团衍生物的样品中至少一种分子的存在或量的方法。

公开(公告)号：EP2150586B1

公开(公告)日：2018-03-14

申请号：EP08756041.3

申请日：2008-05-21

申请人： Becton, Dickinson and Company

发明人： THOMAS, Joseph ,  CASH, Michael, T.

IPC分类号： C09B57/02 ,  G01N33/533 ,  G01N33/58

CPC分类号： G01N33/582 ,  A61K8/498 ,  C09B23/105 ,  C09B57/02 ,  C12M1/34 ,  G01N33/53 ,  G01N33/533 ,  G01N33/66

摘要： The presently disclosed subject matter provides thiol-reactive, environmentally sensitive fluorescent dyes, or fluorophores, which have an emission wavelength in the visible spectral region. When conjugated with a binding protein, the fluorophores exhibit a ratiometric response to one or more ligands or target analytes. The presently disclosed fluorophore-binding protein conjugates can be used to detect the presence of or amount of physiologically-important metabolites, such as glucose, fatty acids, and lactate, in biological samples.

公开(公告)号：EP2480609B1

公开(公告)日：2017-12-27

申请号：EP10757211.7

申请日：2010-09-24

申请人： Commissariat à l'Énergie Atomique et aux Énergies Alternatives

发明人： BUVAT, Pierrick ,  MALOSSE, Lucie ,  SIOVE, Alain ,  ADES, Dominique

IPC分类号： C09B57/02 ,  C09B69/10

CPC分类号： G01N21/64 ,  C08F220/68 ,  C09B57/02 ,  C09B69/109 ,  G01N33/0037 ,  G01N33/0047 ,  G01N33/0057 ,  G01N33/52 ,  G01N2201/06113 ,  G01N2201/068 ,  Y02A50/245 ,  Y10T428/2982 ,  Y10T436/163333 ,  Y10T436/173076

公开(公告)号：EP2215526A1

公开(公告)日：2010-08-11

申请号：EP08855494.4

申请日：2008-11-25

申请人： Rodenstock GmbH

发明人： MELZIG, Manfred ,  ROHLFING, Yven ,  WEIGAND, Udo

IPC分类号： G03C1/73 ,  C07D311/78 ,  C09B57/00 ,  C09B57/02

CPC分类号： G03C1/73 ,  C07D311/94 ,  C09B57/00 ,  G02B5/23

摘要： The present invention relates to photochromic benzopyranes and the use thereof in plastic materials of all types, particularly for ophthalmic purposes. The compounds according to the invention are photochromic benzopyrane compounds, wherein a multi-core aromatic compound is linked to the 5th and 6th positions of a benzopyrane, wherein the linkage in the 6th position occurs directly, and the linkage in the 5th position occurs via a one- or two-atom bridge.

公开(公告)号：EP2036953A3

公开(公告)日：2010-07-14

申请号：EP08017855.1

申请日：2005-05-20

申请人： Becton, Dickinson & Company

发明人： Pitner, Bruce, J. ,  Sherman, Douglas, B. ,  Ambroise, Arounaguiry ,  Thomas, Joseph, K.

IPC分类号： C09B23/00 ,  C09B19/00 ,  C09B23/10 ,  G01N33/533 ,  G01N33/58 ,  C09B57/02

CPC分类号： C09B23/10 ,  C07D207/02 ,  C09B23/105 ,  G01N33/582 ,  G01N33/66

摘要： Reactive fluorescent dyes compositions and methods of using same are disclosed. Coumarin nucleus or aza coumarin nucleus dyes are disclosed having thiol-reactive groups. Coumarin nucleus or aza coumarin nucleus dyes are disclosed that exhibit a fluorescence emission of at least about 575 nm. Biosensors are disclosed having a binding protein and a Coumarin nucleus or aza coumarin nucleus.