公开(公告)号：EP4133062A1

公开(公告)日：2023-02-15

申请号：EP21718847.3

申请日：2021-04-12

申请人： Rnassist Limited ,  Goldsborough, Andrew Simon ,  Bates, Malcolm Robert

发明人： GOLDSBOROUGH, Andrew Simon ,  BATES, Malcolm Robert

IPC分类号： C12N7/06 ,  C11D3/48

公开(公告)号：EP3981873A1

公开(公告)日：2022-04-13

申请号：EP21191783.6

申请日：2013-06-13

申请人： EMD Millipore Corporation

发明人： XENOPOULOS, Alex

IPC分类号： C12N7/04 ,  C12N7/06 ,  C07K1/16 ,  C07K1/36 ,  B01F25/00 ,  B01F25/40 ,  B01D15/00

摘要： The present application relates to novel and improved methods of achieving virus inactivation during a protein purification process.

公开(公告)号：EP2935569B1

公开(公告)日：2019-05-01

申请号：EP13865170.8

申请日：2013-12-20

申请人： Celverum Inc.

发明人： CONRAD, David ,  BATENCHUK, Cory ,  LEBOEUF, Fabrice ,  BELL, John Cameron

IPC分类号： A61K35/76 ,  C12N7/06 ,  A61P35/02

公开(公告)号：EP2704740B1

公开(公告)日：2016-10-05

申请号：EP12731200.7

申请日：2012-05-03

申请人： Streck, Inc.

发明人： RYAN, Wayne L. ,  GRUNKEMEYER, James A.

IPC分类号： A61K39/00 ,  C12N7/06 ,  A61K39/145

CPC分类号： A61K39/275 ,  A61K39/12 ,  A61K2039/5252 ,  C12N7/00 ,  C12N2760/16134 ,  C12N2760/16163

摘要： The present invention is directed at a composition comprising a live swine flu virus having an infectious component and a plurality of surface antigens in contact with a formaldehyde donor agent having a molecular weight that is less than about 400 g/mol. Preferably, the formaldehyde donor agent is selected from a non-crosslinking chemical fixative that contains urea.

公开(公告)号：EP2902485A1

公开(公告)日：2015-08-05

申请号：EP13841603.7

申请日：2013-09-27

申请人： National University Corporation Kobe University ,  Toray Industries, Inc. ,  Tokyo Metropolitan Institute of Medical Science ,  University of Indonesia ,  Indonesian Institute Of Sciences (LIPI)

发明人： HOTTA, Hak ,  AOKI, Chie ,  WAKITA, Takaji ,  PRATIWI, Soedarmono ,  RATNA, Sitompul ,  LUKMAN, Hakim ,  LEONARDUS, Kardono

IPC分类号： C12N7/02 ,  A61K39/29 ,  A61P31/14 ,  C12N7/06 ,  C12Q1/02 ,  C12N15/09

CPC分类号： A61K39/29 ,  A61K31/366 ,  A61K31/40 ,  A61K31/405 ,  A61K35/66 ,  A61K2039/5252 ,  C07D309/10 ,  C12N7/00 ,  C12N2770/24251 ,  C12N2770/28034 ,  C12N2770/28051 ,  C12N2770/28061 ,  C12Q1/18 ,  G01N33/5014 ,  G01N2333/186 ,  G01N2500/04 ,  G01N2500/10 ,  A61K2300/00

摘要： Provided are a HCV particle formation promoter capable of promoting formation of HCV particles in culture cells, and a method of enhancing production of HCV particles. Also provided are a method of evaluating an anti-HCV agent candidate substance, and a method of producing a HCV vaccine. The HCV particle formation promoter comprises as an active ingredient a statin or a pharmaceutically acceptable salt thereof. Addition of the statin or pharmaceutically acceptable salt thereof to HCV-infected culture cells can promote formation of infectious HCV particles and enhance production of the particles. In addition, an anti-HCV agent candidate substance is evaluated by culturing HCV-infected cells in the presence of the HCV particle formation promoter and the anti-HCV agent candidate substance. Further, a HCV vaccine is produced by using HCV particles produced by the method of enhancing production of HCV particles.

摘要翻译： 提供能够促进培养细胞中HCV颗粒形成的HCV颗粒形成促进剂，以及增强HCV颗粒生成的方法。 还提供了评估抗HCV剂候选物质的方法以及HCV疫苗的制备方法。 HCV颗粒形成促进剂包含他汀类或其药学上可接受的盐作为活性成分。 向HCV感染的培养细胞中加入他汀类药物或其药学上可接受的盐可促进感染性HCV颗粒的形成并增加颗粒的产生。 此外，通过在HCV颗粒形成促进剂和抗HCV剂候选物质的存在下培养HCV感染的细胞来评价抗HCV剂候选物质。 此外，通过使用通过增强HCV颗粒的产生的方法产生的HCV颗粒来生产HCV疫苗。

公开(公告)号：EP2867359A1

公开(公告)日：2015-05-06

申请号：EP13810248.8

申请日：2013-06-13

申请人： EMD Millipore Corporation

发明人： XENOPOULOS, Alex

IPC分类号： C12N7/04 ,  C12N7/06 ,  C07K1/16

CPC分类号： C12N7/00 ,  C07K1/16 ,  C07K1/36 ,  C12N2740/10061

摘要： The present application relates to novel and improved methods of achieving virus inactivatlon during a protein purification process.

摘要翻译： 本申请涉及在蛋白质纯化过程中实现病毒灭活的新颖和改进的方法。

公开(公告)号：EP2339006A3

公开(公告)日：2011-10-19

申请号：EP10179891.6

申请日：2000-12-12

申请人： Monsanto Technology LLC

发明人： Fincher, Karen L. ,  Flasinski, Stanislaw ,  Wilkinson, Jack Q.

IPC分类号： C12N15/82 ,  C07K14/415 ,  C12N7/06

CPC分类号： C12N15/8275 ,  A01N57/20 ,  C12N7/00 ,  C12N9/1092 ,  C12N15/8216 ,  C12N15/8221 ,  C12N15/8222 ,  C12N15/8223 ,  C12N15/823 ,  C12N15/8261 ,  C12N15/8286 ,  C12N2710/00043 ,  Y02A40/146 ,  Y02A40/162

摘要： The present invention relates to novel plant expression constructs. More specifically the present invention provides DNA constructs comprising 5' regulatory sequences for modulating the expression of operably linked genes in plants.

摘要翻译： 本发明涉及新的植物表达构建体。 更具体地说，本发明提供了包含5'调节序列的DNA构建体，用于调节植物中可操作连接的基因的表达。

公开(公告)号：EP2339005A2

公开(公告)日：2011-06-29

申请号：EP10179886.6

申请日：2000-12-12

申请人： Monsanto Technology LLC

发明人： Fincher, Karen, L. ,  Flasinski, Stanislaw ,  Wilkinson, Jack Q.

IPC分类号： C12N15/82 ,  C07K14/415 ,  C12N7/06

CPC分类号： C12N15/8275 ,  A01N57/20 ,  C12N7/00 ,  C12N9/1092 ,  C12N15/8216 ,  C12N15/8221 ,  C12N15/8222 ,  C12N15/8223 ,  C12N15/823 ,  C12N15/8261 ,  C12N15/8286 ,  C12N2710/00043 ,  Y02A40/146 ,  Y02A40/162

摘要： The present invention relates to novel plant expression constructs. More specifically the present invention provides DNA constructs comprising 5' regulatory sequences for modulating the expression of operably linked genes in plants.

摘要翻译： 本发明涉及新的植物表达构建体。 更具体地，本发明提供了包含用于调节植物中可操作连接的基因的表达的5'调节序列的DNA构建体。

公开(公告)号：EP2049657A4

公开(公告)日：2009-10-28

申请号：EP07840490

申请日：2007-07-24

申请人： AMERICAN STERILIZER CO

发明人： BURKE PETER A ,  LUDWIG KARL F ,  KRAL JUDE A ,  ZELINA FRANCIS J

IPC分类号： C12N7/06 ,  A61L2/02 ,  A61L2/16 ,  A61L2/18 ,  C02F1/44 ,  C02F1/50 ,  C02F1/68 ,  C02F1/72 ,  C02F9/00

CPC分类号： A61L2/18 ,  A61L2/022 ,  A61L2/16 ,  C02F1/001 ,  C02F1/02 ,  C02F1/32 ,  C02F1/44 ,  C02F1/444 ,  C02F1/50 ,  C02F1/688 ,  C02F1/722 ,  C02F9/00 ,  C02F9/005 ,  C02F2301/08

摘要： The present invention provides a method of operating a reprocessor that has a chamber for receiving items to be sterilized. The reprocessor is filled with water that has passed through a first and a second filter element that both comprise a filtration system. A liquid sterilant is generated by mixing the water with dry chemical reagents. The liquid sterilant is circulated through a fluid circulation system and the filtration system wherein a portion of the liquid sterilant is directed through a bypass conduit and another portion is directed through the first and second filter elements. After a predetermined exposure time, the reprocessor is drained. Then the reprocessor is filled with water for rinsing that has passed through the first and the second filter elements. The water for rinsing is heated prior to being introduced into the reprocessor.

公开(公告)号：EP1958626A1

公开(公告)日：2008-08-20

申请号：EP08250527.2

申请日：2008-02-13

申请人： Ajinomoto Co., Inc.

发明人： Koyama, Hajime ,  Arakawa, Tsutomu ,  Ejima, Daisuke

IPC分类号： A61K31/198 ,  C12N7/06 ,  A23L1/305

CPC分类号： A01N47/44 ,  A23L3/3508 ,  A23V2002/00 ,  A61K31/198 ,  A61K2039/5252 ,  C12N7/00 ,  C12N7/04 ,  C12N7/06 ,  C12N2710/16663 ,  C12N2760/16163 ,  C12N2760/18863 ,  A23V2200/10 ,  A23V2250/0606

摘要： The present invention provides a method for conveniently producing a protein formulation with viruses being inactivated, without impairing the quality of the obtained protein formulation, characterized by including the step of exposing the protein formulation contaminated with the viruses to a 0.1-2M aqueous solution of arginine, an arginine derivative or a mixture thereof, the aqueous solution being adjusted to pH 3.5 to 5. The present invention also provides a virus inactivation method characterized by including the step of bringing a virus-containing object into contact with a 0.1-2M aqueous solution of arginine, a arginine derivative or a mixture thereof, the aqueous solution being adjusted to pH 3.5 to 5.

摘要翻译： 本发明提供了一种用于方便地制造具有病毒蛋白质制剂被灭活，而不会损害所得到的蛋白质制剂的质量，通过包括沾染的病毒的蛋白质制剂暴露于精氨酸0.1-2Mwässrige溶液的步骤为特征的 ，精氨酸衍生物或它们的混合物的5日，wässrige溶液被调节至pH为3.5，本发明提供这样通过包括使含病毒的对象接触到一个0.1-2M溶液wässrige的步骤为特征的病毒灭活方法 精氨酸，精氨酸衍生物或它们的混合物，所述溶液wässrige被调整至pH 3.5至第五