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公开(公告)号：EP1051501A1
公开(公告)日：2000-11-15
申请号：EP99906207.8
申请日：1999-01-27
摘要： The present invention relates to a nucleic acid molecule which codes for the cephalosporin acetylesterase from Bacillus subtilis ATCC 6633 (DSM 11909), vectors and host cells which comprise such a nucleic acid molecule, a process for the recombinant preparation of cephalosporin acetylesterase from B. subtilis ATCC 6633 (DSM 11909) using said nucleic acid molecule, and a process for preparing 3-deacetylcephalosporin compounds.
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2.发明公开7-Beta-substituted-3-lower alkanoylacetoxymethyl-7-alpha-methoxy-3-cephem-4-carboxylic acid and process for production of same 失效7-β-取代-3- alkanoylacetoxymethyl低7-α-甲氧基-3-头孢烯-4-羧酸和它们的制备方法。
公开(公告)号：EP0290136A2
公开(公告)日：1988-11-09
申请号：EP88302955.5
申请日：1988-03-31
发明人： Abe, Masami , Eiki, Hideo
IPC分类号： C07D501/57 , C12P35/08
CPC分类号： C12P35/08
摘要： 7β-substituted-3-lower alkanoylacetoxymethyl-7α-methoxy-3-cephem-4-carboxylic acid of formula (I) and salts thereof :
(wherein R¹ represents a lower alkyl group and R² represents an amino group which may be protected) are useful intermediates for preparing anti-bacterial cephamycin compounds.摘要翻译： 7测试取代-3-低级alkanoylacetoxymethyl -7-阿尔法 - 甲氧基-3-头孢烯-4-羧酸式（I）及其盐：
（其中，R <1>表示低级烷基，R <2 >可被保护的氨基）的darstellt可用于制备抗菌化合物头霉素有用的中间体。 -
3.发明公开7-Formylaminocephalosporin compounds and microorganism and process for their production 失效7-甲基胺环磷酰胺化合物和微生物及其生产方法
公开(公告)号：EP0212893A3
公开(公告)日：1988-09-21
申请号：EP86305951
申请日：1986-08-01
发明人： Imai, Harumitsu , Suzuki, Ken-ichi , Nagai, Koji , Miyazaki, Sigeru , Abe, Kenji , Takahashi, Isao , Tanaka, Koichi , Kadota, Shigenobu
IPC分类号： C07D501/57 , C12P35/08 , C12P35/06 , C12N01/20 , C12R01/38
摘要： Antibacterial 7-formylaminocephalosporin compounds of formula (1) or salt thereof
wherein
R' represents a carboxy group or an aminocarboxymethyl group
R 2 represents a hydrogen atom or an esterifying group, and R 3 represents a group having a 5- 6-membered heterocyclic ring, and processes for producing them. The compounds show antibacterial activity and are useful intermediates for other cephalosporin compounds having antibacterial activity.-
公开(公告)号：EP0150378A2
公开(公告)日：1985-08-07
申请号：EP84115168.1
申请日：1984-12-11
IPC分类号： C07D501/57 , C12P35/08
摘要： A compound of the formula:
wherein R' is
or hydrogen, or a salt thereof, is useful as an intermediate forthe production of cephem compounds, and some of them are useful as antimicrobial agent.-
5.发明公开Cephalosporins, processes for their preparation and microorganisms capable of their production 失效头孢菌素类，它们的制备方法以及它们的生产合适的微生物。
公开(公告)号：EP0028511A1
公开(公告)日：1981-05-13
申请号：EP80303870.2
申请日：1980-10-30
申请人： GLAXO GROUP LIMITED
发明人： Brown, David , Giles, Anthony Frederick , Cramer, Howard William , Noble, Hazel Mary , Nisbet, Louis Joseph , Bushell, Michael Edward , Weare, Glenis , Caldwell, Ian Yeatman
IPC分类号： C12P35/08 , C07D501/28 , C12N1/20
摘要： Cephamycin compounds of the formula (I)
wherein R 1 represents hydroxyl or sulphooxy and R 2 represents sulphooxy together with derivatives thereof including salts, esters, N-protected derivatives and solvates thereof are disclosed. These compounds are of great value as intermediates in the preparation of other cephamycin compounds.
The compounds of the invention may be isolated from fermentation broths of strains of the genus Streptomyces which produce the compounds and a new such strain is described. The isolation of the compounds may be achieved by a liquid/liquid or liquid/solid ion-exchange technique, and is preferably achieved by the formation of an ion-pair in a liquid/liquid technique.-
6.发明公开7-Beta-substituted-3-lower alkanoylacetoxymethyl-7-alpha-methoxy-3-cephem-4-carboxylic acid and process for production of same 失效7-取代的3-低级烷基酰氧基甲基-7-羟基-3-甲氧基-3-羧基-4-羧酸及其生产方法
公开(公告)号：EP0290136A3
公开(公告)日：1990-03-14
申请号：EP88302955.5
申请日：1988-03-31
发明人： Abe, Masami , Eiki, Hideo
IPC分类号： C07D501/57 , C12P35/08
CPC分类号： C12P35/08
摘要： 7β-substituted-3-lower alkanoylacetoxymethyl-7α-methoxy-3-cephem-4-carboxylic acid of formula (I) and salts thereof :
(wherein R¹ represents a lower alkyl group and R² represents an amino group which may be protected) are useful intermediates for preparing anti-bacterial cephamycin compounds.-
公开(公告)号：EP0216636A3
公开(公告)日：1988-09-28
申请号：EP86307324
申请日：1986-09-24
发明人： Abe, Masami , Tamura, Mamoru , Eiki, Hideo
摘要： A process for producing oganomycin E from cephamycin compound by the action of an esterase is disclosed. The cephamycin for reaction may be provided in situ bacterially. Esterase activity is provided by yeast of genus Torulopsis or by an esterase derived from the yeast. Type strain Torulopgis sp. YE-08907L is described as representative of a yeast having the characteristic enzymic esterase activity.
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公开(公告)号：EP0150378A3
公开(公告)日：1986-03-26
申请号：EP84115168
申请日：1984-12-11
IPC分类号： C07D501/57 , C12P35/08
摘要： A compound of the formula:
wherein R' is
or hydrogen, or a salt thereof, is useful as an intermediate forthe production of cephem compounds, and some of them are useful as antimicrobial agent.-
9.发明授权Cephalosporins, processes for their preparation and microorganisms capable of their production 失效CEPHALOSPORINS，其制备方法及其生产能力的微生物
公开(公告)号：EP0028511B1
公开(公告)日：1984-04-11
申请号：EP80303870.2
申请日：1980-10-30
申请人： GLAXO GROUP LIMITED
发明人： Brown, David , Giles, Anthony Frederick , Cramer, Howard William , Noble, Hazel Mary , Nisbet, Louis Joseph , Bushell, Michael Edward , Weare, Glenis , Caldwell, Ian Yeatman
IPC分类号： C12P35/08 , C07D501/28 , C12N1/20
摘要： Cephamycin compounds of the formula (I) (I) wherein R1 represents hydroxyl or sulphooxy and R2 represents sulphooxy together with derivatives thereof including salts, esters, N-protected derivatives and solvates thereof are disclosed. These compounds are of great value as intermediates in the preparation of other cephamycin compounds. The compounds of the invention may be isolated from fermentation broths of strains of the genus Streptomyces which produce the compounds and a new such strain is described. The isolation of the compounds may be achieved by a liquid/liquid or liquid/solid ion-exchange technique, and is preferably achieved by the formation of an ion-pair in a liquid/liquid technique.
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公开(公告)号：EP0216636A2
公开(公告)日：1987-04-01
申请号：EP86307324.3
申请日：1986-09-24
发明人： Abe, Masami , Tamura, Mamoru , Eiki, Hideo
摘要： A process for producing oganomycin E from cephamycin compound by the action of an esterase is disclosed. The cephamycin for reaction may be provided in situ bacterially. Esterase activity is provided by yeast of genus Torulopsis or by an esterase derived from the yeast. Type strain Torulopgis sp. YE-08907L is described as representative of a yeast having the characteristic enzymic esterase activity.
摘要翻译： 公开了一种通过酯酶的作用生产具有由式：
表示的来自头孢霉素的结构式为：CHEM>的生物质的黑头霉素E的方法。 可以原位细菌提供用于反应的头孢霉素。 酯酶活性由Torulopsis属的酵母或由酵母衍生的酯酶提供。 类型菌株Torulopsis sp。 YE-08907L被描述为具有特征酶活性的酵母的代表。
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