公开(公告)号：EP4462438A3

公开(公告)日：2025-02-26

申请号：EP24189554.9

申请日：2016-10-07

Applicant: Guardant Health, Inc.

Inventor： ELTOUKHY, Helmy ,  TALASAZ, Amir-Ali

IPC: C12Q1/68 ,  G01N33/48 ,  G01N33/574 ,  C12Q1/6883 ,  C12Q1/6886 ,  G16H20/00 ,  G16B40/00 ,  G16B50/00 ,  G16B40/20 ,  G16B40/30 ,  G16B50/20

Abstract: Systems and methods are disclosed for generating a therapeutic response predict or detecting a disease, by: using a genetic analyzer to generate genetic information; receiving into computer memory a training dataset comprising, for each of a plurality of individuals having a disease, (1) genetic information from the individual generated at first time point and (2) treatment response of the individual to one or more therapeutic interventions determined at a second, later, time point; and implementing a machine learning algorithm using the dataset to generate at least one computer implemented classification algorithm, wherein the classification algorithm, based on genetic information from a subject, predicts therapeutic response of the subject to a therapeutic intervention.

公开(公告)号：EP4185716B1

公开(公告)日：2025-02-19

申请号：EP21755837.8

申请日：2021-07-22

Inventor： GANCI, Federica ,  SPINELLA, Francesca ,  FIORENTINO, Francesco ,  BLANDINO, Giovanni

IPC: C12Q1/6886

公开(公告)号：EP3169797B2

公开(公告)日：2025-02-19

申请号：EP15734713.9

申请日：2015-07-13

Inventor： LEVESQUE, Mitchell Paul ,  DUMMER, Reinhard ,  WIDMER, Daniel ,  RAAIJMAKERS, Marieke Ineke Geertje

IPC: C12Q1/6886

公开(公告)号：EP4501930A1

公开(公告)日：2025-02-05

申请号：EP23778490.5

申请日：2023-03-31

Applicant: Shanghai Shijiang Biotechnology Co., Ltd

Inventor： SHI, Yufeng ,  MA, Wenjiang ,  WANG, Yingcai

IPC: C07D471/04 ,  C07D213/74 ,  C07D401/04 ,  C07C237/40 ,  C07D277/42 ,  C07D233/60 ,  C07D401/06 ,  C07D239/42 ,  C07D213/75 ,  A61P35/00 ,  A61P35/02 ,  C12Q1/6886 ,  C12Q1/02

Abstract: The present invention relates to an aromatic ring compound and use thereof. Specifically proyided is a compound of formula I, or an optical isomer thereof, or a racemate thereof, or a solvate thereof, or a pharmaceutically acceptable salt thereof, or a deuterated compound thereof. The compound has a significantly excellent therapeutic effect on tumors with low expression, no expression, low activity or no activity of mitochondrial permeablity transition pores; low expression, no expression, low activity or no activity of peptidyl-prolyl isomerase F; low expression or no expression of the NNMT gene; high expression of DNA methylases; high expression of UHRFl; high levels of methylation of nucleotide sites in the NNM'T gene; and/or high levels of methylation of DNA CpG sites in the NNMT gene region.

公开(公告)号：EP4496904A2

公开(公告)日：2025-01-29

申请号：EP23775786.9

申请日：2023-03-06

Applicant: Arima Genomics, Inc.

Inventor： SCHMITT, Anthony ,  SIKKINK, Kristin

IPC: C12Q1/6886 ,  A61P35/00 ,  C12N15/12

公开(公告)号：EP4493690A2

公开(公告)日：2025-01-22

申请号：EP23771682.4

申请日：2023-03-16

Applicant: EMPIRICO INC.

Inventor： GOTTESMAN, Omri ,  ALLEN, Andrew ,  BRUSE, Shannon ,  CAJES, Brian ,  JAKUBOSKY, David ,  LEWIS, David ,  MCINNES, Gregory ,  O'ROURKE, Jason ,  ROZEMA, David ,  BUSKE, Paul

IPC: C12N15/11 ,  C12Q1/6886 ,  A61P35/00

公开(公告)号：EP3896170B1

公开(公告)日：2025-01-22

申请号：EP19883631.4

申请日：2019-11-18

Inventor： CHEN, Qihan

IPC: C12Q1/68 ,  C07K14/46 ,  C12N9/22 ,  C12Q1/6886 ,  G01N33/574

公开(公告)号：EP4491182A1

公开(公告)日：2025-01-15

申请号：EP23766144.2

申请日：2023-03-10

Applicant: Shanghai Shijiang Biotechnology Co., Ltd

Inventor： SHI, Yufeng ,  MA, Wenjiang

IPC: A61K31/4745 ,  C07D455/03 ,  C12Q1/6886 ,  A61P35/00

Abstract: The present invention relates to an application of a tetracyclic compound in the treatment of tumors. Specifically provided is a use of a compound of formula I, an optical isomer or racemate thereof, a solvate thereof, a pharmaceutically acceptable salt thereof or a deuterated compound thereof, which is used for preparing a composition or a formulation, said composition or formulation being used for preventing and/or treating tumors. A compound of the invention has a uniquely advantageous precision treatment effect on tumors having low expression or no expression of the NNMT gene, high expression of a DNA methylase, high expression of UHRFI, a high NNMT gene nucleotide site methylation level, and/or a high NNMT gene region DNA CpG site methylation level.

公开(公告)号：EP4490324A2

公开(公告)日：2025-01-15

申请号：EP23767589.7

申请日：2023-03-06

Applicant: Arima Genomics, Inc.

Inventor： SCHMITT, Anthony ,  SIKKINK, Kristin ,  REID, Bret Derek

IPC: C12Q1/6886 ,  C12Q1/6813 ,  C12Q1/6869

公开(公告)号：EP4486921A1

公开(公告)日：2025-01-08

申请号：EP23762893.8

申请日：2023-03-01

Applicant: Crown Bioscience (Suzhou) Inc.

Inventor： MAO, Binchen ,  GUO, Sheng ,  LI, Henry Qixiang

IPC: C12Q1/6886