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    METHOD FOR EXTRACTING SUBSTANCE SOLUBLE IN ORGANIC SOLVENT
    93.
    发明专利
    METHOD FOR EXTRACTING SUBSTANCE SOLUBLE IN ORGANIC SOLVENT 失效

    公开(公告)号：JPS6271501A

    公开(公告)日：1987-04-02

    申请号：JP21346885

    申请日：1985-09-26

    Applicant: NITTO ELECTRIC IND CO

    Inventor： HIGUCHI TOSHIO ,  MATSUMURA TAKEO ,  SASAKI TAKESHI ,  SHIMATANI SHUNICHI

    IPC: C07B63/00 ,  A61K35/60 ,  A61K35/74 ,  A61K36/00 ,  A61K36/258 ,  B01D11/02 ,  B01D63/00 ,  B01D65/00 ,  C07B31/00 ,  C07C67/00 ,  C11B1/10 ,  C11B9/00 ,  C12P17/02 ,  C12P19/44 ,  C12R1/38

    Abstract: PURPOSE:To conveniently obtain a substance soluble in an org. solvent in high yield by dipping a sample body contg. a substance to be extracted soluble in the org. solvent through a porous membrane. CONSTITUTION:The sample body 1 contained in a porous membrane 3 consisting of a polyimide film, etc., and an org. solvent 2 are supplied into an extraction vessel 4. The amt. of the org. solvent is so regulated that the sample body 1 is sufficiently immersed. The extraction vessel 4 is heated by using a heater 5, cooling water is passed through a Dimroth condenser 6, the org. solvent in the extraction vessel 4 is refluxed and the substance to be extracted in the sample body 1 is extracted into the org. solvent. The substance dissolved in the org. solvent is permeated through the porous membrane 3. The substance insoluble in the org. solvent is incapable of being permeated through the porous membrane 3. Consequently, the substance in the sample body 1 soluble in the org. solvent and the substance insoluble in the org. solvent are separated by the porous membrane 3.

    Preparation of optically active hydantoin
    96.
    发明专利
    Preparation of optically active hydantoin 失效
    光学活性橙皮苷的制备

    公开(公告)号：JPS6172762A

    公开(公告)日：1986-04-14

    申请号：JP19539284

    申请日：1984-09-17

    Applicant: Kanegafuchi Chem Ind Co Ltd

    Inventor： TAKAHASHI SATOMI ,  YAMADA YUKIO ,  UEDA YASUYOSHI ,  KATAYAMA YASUHIRO ,  SHIMADA YOSHIO ,  WATANABE KIYOSHI

    IPC: C07D233/72 ,  C07D233/74 ,  C07D311/68 ,  C07D317/60 ,  C07D405/06 ,  C07D491/10 ,  C12P17/02 ,  C12P17/10 ,  C12P17/18 ,  C12P41/00 ,  C12R1/01 ,  C12R1/07 ,  C12R1/15 ,  C12R1/365

    CPC classification number: C07D405/06 ,  C07D233/74 ,  C07D311/68 ,  C07D317/60 ,  C07D491/10 ,  C12P17/02 ,  C12P17/10 ,  C12P17/18 ,  C12P41/009

    Abstract: PURPOSE: To convert enzymatically only one steric configuration of racemic modification of N-carbamoyl-α-amino acid obtained easily from hydantoins or α-amino acid to hydrantoins, and further to separate and to collect unused antipode.
    CONSTITUTION: Only one steric configuration of racemic modification of an N-carbamoyl-α-amino acid shown by the formula I (R
    1 and R
    2 are alkyl, aralkyl, aryl, or R
    1 and R
    2 form one unsymmetrical cyclic compound) is enzymatically converted to corresponding hydantoins by the use of a bacterium belonging the genus Aerobacter, Agrobacterium, Bacillus, corynabacterium, etc., to give an optically active hydantoin [e.g., (R) form shown by the formula III, etc.] shown by the formula II. Further, separated unreacted optically active N- carbamoyl-α-amino acid is subjected to ring formation under acidic conditions under heating to give a corresponding optically active hydantoin.
    USE: A drug and an intermediate for drugs.
    COPYRIGHT: (C)1986,JPO&Japio

    Abstract translation: 目的：为了酶的转化，只能从乙内酰脲或α-氨基酸容易地得到N-氨基甲酰基-α-氨基酸的外消旋修饰的一个立体构型到乙内酰脲，并进一步分离并收集不使用的对映体。 结构式：式I（R 1和R 2）所示的N-氨基甲酰基-α-氨基酸的外消旋体的仅有一个立体构型是烷基，芳烷基，芳基或R 1和R 2 >形成一个不对称环状化合物）通过使用属于气杆菌属，农杆菌属，芽孢杆菌属，棒状杆菌属等的细菌酶促转化成相应的乙内酰脲，得到光学活性的乙内酰脲[例如，式 III等]。 此外，分离的未反应的光学活性N-氨甲酰基-α-氨基酸在酸性条件下加热形成环状，得到相应的光学活性乙内酰脲。 用途：药物和药物中间体。

    PREPARATION OF EPOXIDE FROM ALLYL PHENYL ETHER
    97.
    发明专利
    PREPARATION OF EPOXIDE FROM ALLYL PHENYL ETHER 失效

    公开(公告)号：JPS60251894A

    公开(公告)日：1985-12-12

    申请号：JP10804084

    申请日：1984-05-28

    Applicant: NIPPON MINING CO

    Inventor： FURUHASHI KEIZOU ,  TAKAGI KIFUKU

    IPC: C07D303/22 ,  C07C217/30 ,  C12P17/02 ,  C12R1/365

    Abstract: PURPOSE:To obtain a 2,3-epoxypropyl ether useful as an intermediate for drugs, by treating an allyl phenyl ether with a specific bacterium capable of producing epoxide to give an epoxide, separating and collecting the epoxide. CONSTITUTION:An allyl phenyl ether is treated with a bacterium beloning to the genus Nocardia, capable of producing an epoxide under an aerobic condition, to produce a corresponding 2,3-epoxypropyl phenyl ether. Then, the prepared epoxide is separated and collected. Or, the compound is treated with the bacterium in the presence of a water-insoluble organic solvent, so that the epoxide can be produced much more advantageously. An aromatic ether such as allyl phenyl ether or naphthyl allyl ether, having no substituent group on the aromatic ring may be cited as the allyl phenyl ether usable as a raw material substrate.

    Production of epoxide
    100.
    发明专利
    Production of epoxide 失效
    环氧化物的生产

    公开(公告)号：JPS59216595A

    公开(公告)日：1984-12-06

    申请号：JP9108683

    申请日：1983-05-24

    Applicant: Baiorisaac Center:Kk

    Inventor： SHINTANI MAKOTO ,  FURUHASHI KEIZOU ,  TAKAGI KIFUKU

    IPC: C12P17/02 ,  C12R1/365

    Abstract: PURPOSE: To produce the corresponding epoxide useful as a raw material or intermediate for producing synthetic resins and medicines, etc., by reacting an olefin having an aromatic ring with a specific microorganism.
    CONSTITUTION: An olefin having an aromatic ring, e.g. styrene or allylbenzene, is reacted with a microorganism, e.g. Nocardia corallina (FERM-P No. 4094), belonging to the genus Nocardia, and having the ability to produce epoxides under aerobic conditions preferably at 6W8 pH and 25W45°C for 1W6 days.
    COPYRIGHT: (C)1984,JPO&Japio

    Abstract translation: 目的：通过使具有芳环的烯烃与特定的微生物反应，生产用作生产合成树脂和药物等的原料或中间体的相应的环氧化物。 构成：具有芳香环的烯烃，例如 苯乙烯或烯丙基苯与微生物例如 属于诺卡氏菌属的诺卡氏菌（FERM-P No.4094），并且在需氧条件优选在6-8 pH和25-45℃下产生环氧化物1-6天的能力。

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