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    ANTIDEMENTIAL AGENT
    41.
    发明专利
    ANTIDEMENTIAL AGENT 失效

    公开(公告)号：JPS62252726A

    公开(公告)日：1987-11-04

    申请号：JP9473886

    申请日：1986-04-25

    Applicant: HOECHST JAPAN

    Inventor： GOTO MASAYOSHI ,  DEMURA NOBUTAKA ,  OSAKI TSUTOMU

    IPC: A61K31/70 ,  A61K31/7042 ,  A61K31/7052 ,  A61K31/7076 ,  A61P25/28 ,  C07H19/16 ,  C07H19/167

    Abstract: PURPOSE:An antidemential agent containing an adenosine derivative as an active ingredient. CONSTITUTION:An antidemential agent obtained by containing a compound expressed by the formula (R1 is H or halogen; R2 is H, alkyl, cycloalkyl or aralkyl; R3 is hydroxymethyl except when R1 and R2 are same and H; R3 is hydroxymethyl) as an active ingredient. The agent is effective against senile dementia and a valuable drug effective for treating dysmnesia. The dose thereof is 2-1,000mg/adult/day expressed in terms of the adenosine derivative. The administration can be intravenously, intramuscularly, orally and intrarectally carried out. The compound expressed by the formula has a low toxicity as compared with the pharmacologically active dose and can be continuously administered.

    DETERMINATION OF BETA-LACTAMASE AND MATERIAL USED THEREFOR
    43.
    发明专利
    DETERMINATION OF BETA-LACTAMASE AND MATERIAL USED THEREFOR 失效

    公开(公告)号：JPS61249400A

    公开(公告)日：1986-11-06

    申请号：JP9007785

    申请日：1985-04-26

    Applicant: HOECHST JAPAN

    Inventor： KOBAYASHI SHINZO ,  ARAI SUSUMU

    IPC: G01N33/50 ,  C12Q1/34

    Abstract: PURPOSE:A solid culture medium for gram-negative bacteria to which a specific quantitative indicator is combined with a specimen, subjected to cultivation to determine beta-lactamase whereby the resistance of a gram-negative bacterium of beta-lactamse is quantitatively measured. CONSTITUTION:A solid culture medium for gram-negative bacteria which contains 3-(2-azo-p-dimethylanilino-1-pyridiummethyl)-(6R, 7R)-(2-thienylacet amide)-3-cephem-4-carboxylate which changes its color from violet to yellow by hydrolysis with beta-lactamase is inoculated with a specimen and cultured. When the specimen produces beta-lactamase, a ring of color-changing zone is formed around the colony and the size of the color-changing zone is logarithmi cally proportional to the production of beta-lactamase.

    REMEDY FOR MEMORY DISORDER
    44.
    发明专利
    REMEDY FOR MEMORY DISORDER 失效

    公开(公告)号：JPS61229823A

    公开(公告)日：1986-10-14

    申请号：JP7118885

    申请日：1985-04-05

    Applicant: HOECHST JAPAN

    Inventor： GOTO MASAYOSHI ,  DEMURA NOBUTAKA ,  SAKAGUCHI TAKASHI

    IPC: C07D473/06 ,  A61K31/52 ,  A61K31/522 ,  A61P25/28

    Abstract: PURPOSE:The titled remedy containing 3,7-dihydro-3-methyl-1-(5-oxohexyl)-7- propyl-1H-purine-2,6--dione as an active constituent. CONSTITUTION:A remedy for cerebropathy, particularly memory disorder containing a compound expressed by the formula (propentofylline) as an active constituent. The cerebropathy may be primarily caused by the nervous system containing glial cells and the cerebrovascular system. As the mental and physical symptoms, dementia includes Alzheimer's dementia (progressive and recognized forgetfulness, disorientation of time and place and hypobulia rapidly worsening from the initial period of outbreak) and cerebrovascular dementia caused by cerebrovascular disorder. The prepentofylline is particularly effective for mem ory disorder in the various symptoms. The dose thereof is 100-1,500mg/day, and the continuous administration is possible due to the low toxicity. The rem edy can be administered by the methods of intravascular, intramuscular, oral and rectal administration.

    Iridescence imparting agent
    45.
    发明专利
    Iridescence imparting agent 失效
    防雷剂代理

    公开(公告)号：JPS59164713A

    公开(公告)日：1984-09-17

    申请号：JP3899783

    申请日：1983-03-11

    Applicant: Hoechst Japan Kk

    Inventor： TAKEUCHI HIDEO

    IPC: C08K5/00 ,  A61K8/00 ,  A61K8/02 ,  A61K8/37 ,  A61K8/39 ,  A61K8/40 ,  A61Q5/00 ,  C08K5/06 ,  C08K5/10 ,  C08K5/17 ,  C08K5/19 ,  C11D3/20 ,  C11D3/40 ,  D06M13/02 ,  D06M13/224 ,  D06M13/322 ,  D06M13/46 ,  D06M13/463

    Abstract: PURPOSE: A stable iridescence imparting agent containing an alkanediol diester, a quaternary ammonium salt, a nonionic surfactant and further if necessary an ester of a polyhydric alcohol condensate with a fatty acid or an inorganic salt.
    CONSTITUTION: An iridescence imparting agent containing 3W40wt% compound expressed by formula I (R and R' are 12W24C alkyl; n is an integer 1W10), 3W 15wt% compound expressed by formula II (one or two of R
    1 , R
    2 , R
    3 and R
    4 are 8W24C alkyl or hydroxyalkyl; the rest are 1W3C alkyl, hydroxyalkyl or benzyl; X is halogen, etc.), 0.1W5wt% nonionic surfactant expressed by formula III (R is 8W24C alkyl; n is an integer 0W20) and if necessary an ester of a polyhydric alcohol condensate expressed by formula IV with a fatty acid or an inorganic salt. The above-mentioned imparting agent can be stably incorporated in a cationic surfactant system, e.g. a hair rinse, hair treatment, softener for clothing, etc.
    COPYRIGHT: (C)1984,JPO&Japio

    Abstract translation: 目的：含有链烷二醇二酯，季铵盐，非离子表面活性剂和必要时的多元醇缩合物与脂肪酸或无机盐的酯的稳定的虹彩赋予剂。 构成：含有3-40重量％由式I表示的化合物（R和R'是12-24C烷基; n是整数1-10）的彩虹赋予剂，3-15重量％由式II表示的化合物（一个或两个 R1，R2，R3和R4分别为8-24C烷基或羟基烷基，其余为1-3C烷基，羟烷基或苄基; X为卤素等），0.1-5wt％由式Ⅲ表示的非离子表面活性剂（R为8- 24C烷基; n为0-20的整数），如果需要，由式IV与脂肪酸或无机盐表示的多元醇缩合物的酯。 上述赋予剂可以稳定地加入到阳离子表面活性剂体系中， 头发冲洗，头发处理，服装软化剂等

    LEAKAGE DETECTOR FOR VOLATILE ORGANIC SUBSTANCE WITH WATER-PROOF MECHANISM
    46.
    发明专利
    LEAKAGE DETECTOR FOR VOLATILE ORGANIC SUBSTANCE WITH WATER-PROOF MECHANISM 失效

    公开(公告)号：JPH10267840A

    公开(公告)日：1998-10-09

    申请号：JP6859797

    申请日：1997-03-21

    Applicant: HOECHST JAPAN

    Inventor： TAKANO YUSUKE ,  YAMAMOTO HIRONOBU ,  TAKAYA AKIHIRO ,  ASULEE F SABIN ,  JAMES B SUTAMATOFU

    IPC: G01N21/41 ,  G01M3/00 ,  G01M3/04

    Abstract: PROBLEM TO BE SOLVED: To provide a leakage detector for volatile organic substance to which no influence of water, etc., is given and a leakage monitoring system using it. SOLUTION: This detector is provided with a light source 2 and a detection part 10 having a detection element 8 with a polymer thin film 4 where at least one of thin film and the index of refraction is changed due to contact with an organic substance vapor. A light from the light source 2 enters the polymer thin film 4 and its reflected light is picked up by an optical transmission/output part 14. The detection part 10 is provided with a vapor introduction port, which is provided with such a mechanism as to prevent a water from entering the inside of the detection part 10.

    NEW THERAPEUTIC AGENT FOR ULCERATIVE COLITIS
    47.
    发明专利
    NEW THERAPEUTIC AGENT FOR ULCERATIVE COLITIS 失效

    公开(公告)号：JPH09157182A

    公开(公告)日：1997-06-17

    申请号：JP34745895

    申请日：1995-12-06

    Applicant: HOECHST JAPAN

    Inventor： ARAI YOSHINORI ,  TAKANASHI HITOSHI

    IPC: A61K38/00 ,  A61P1/00 ,  A61P1/04 ,  C07K14/705 ,  C07K14/715

    Abstract: PROBLEM TO BE SOLVED: To obtain the subject therapeutic agent, comprising a mammalian interleukin-1 receptor or its specific fragment as an active ingredient, capable of manifesting excellent suppressing actions on shortening of an alimentary canal due to ulcerative colitis, having high safety and useful for preventing and treating the ulcerative colitis. SOLUTION: This new therapeutic agent for ulcerative colitis comprises (A) a mammalian interleukin-1 receptor (e.g. the one derived from a human) or (B) a fragment of the ingredient (A) including a physiologically active part (e.g. a protein which is a soluble fragment of a human I type interleukin-1 receptor comprising an amino acid sequence of the formula) as an active ingredient. Furthermore, the agent can be intravenously or intramuscularly be administered and prepared as, e.g. a powdery pharmaceutical preparation for injection. The agent is preferably administered in 1-15mg daily dose for an adult, expressed in terms of the amount of the exemplified protein in the ingredient (B).

    NEW PROTEIN HMW HUMAN MP52
    50.
    发明专利
    NEW PROTEIN HMW HUMAN MP52 失效

    公开(公告)号：JPH0931098A

    公开(公告)日：1997-02-04

    申请号：JP21802295

    申请日：1995-07-24

    Applicant: HOECHST JAPAN

    Inventor： KIMURA MICHIO ,  MATSUMOTO TOMOAKI ,  TAKAHASHI MIKIKO ,  KAWAI SHINJI ,  FUJINO YUKIO

    IPC: C12N15/09 ,  A61K38/00 ,  A61P3/00 ,  A61P19/10 ,  A61P43/00 ,  C07K14/47 ,  C07K14/51 ,  C12N5/10 ,  C12N15/12 ,  C12P21/02 ,  C12R1/91

    Abstract: PROBLEM TO BE SOLVED: To obtain the subject new protein having a specific amino acid sequence, inducing the formation of cartilage from undifferentiated mesenchymal cell, exhibiting actions to promote the differentiation and maturation of osteoblast and useful for the treatment, prevention, etc., of osteoporosis, bone fracture, damage of tooth, wound, etc. SOLUTION: This new protein HMW(high-molecular weight) human MP52 is composed of the dimer of the peptide having the 1st to the 474th amino acid sequence of formula, the dimer of the peptide having the 121st to the 474th amino acid sequence of formula, the dimer of the peptide having the 122nd to the 474th amino acid sequence of formula, the dimer of the peptide having the 121st to the 474th amino acid sequence of formula and the 122nd to the 474th amino acid sequence of formula, the dimer of the peptide having the 1st to the 474th and the 121th (122nd) to the 474th amino acid sequence of formula, the dimer of the peptide having the 1st to the 474th and the 355th to the 474th amino acid sequence of formula and the dimer of the peptide having the 121st (122nd) to the 474th and the 355th to the 474th amino acid sequence of formula. The substance is useful for the prevention, treatment, etc., of osteoporosis, bone fracture, wound, etc.

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