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    Percutaneous absorption type preparation
    51.
    发明专利
    Percutaneous absorption type preparation 审中-公开
    PERCUTANEOUS吸收式制备

    公开(公告)号：JP2012126739A

    公开(公告)日：2012-07-05

    申请号：JP2012070208

    申请日：2012-03-26

    Applicant: Kyorin Pharmaceutical Co Ltd ,  Ono Pharmaceut Co Ltd ,  小野薬品工業株式会社 ,  杏林製薬株式会社

    Inventor： TAKAHASHI KOICHI ,  SAKAI YOSHINORI

    IPC: A61K31/4164 ,  A61K9/70 ,  A61K47/06 ,  A61K47/10 ,  A61K47/12 ,  A61K47/14 ,  A61K47/16 ,  A61K47/22 ,  A61K47/32 ,  A61K47/34 ,  A61P1/04 ,  A61P11/00 ,  A61P11/06 ,  A61P13/10

    CPC classification number: A61K9/7053 ,  A61K9/7069 ,  A61K31/4164

    Abstract: PROBLEM TO BE SOLVED: To provide a percutaneous absorption type preparation which comprises 4-(2-methyl-1-imidazolyl)-2,2-diphenylbutylamide as the active ingredient and a backbone for transdermal system, and satisfies at lest one of the following conditions (1) and (2).SOLUTION: The phermaceutical preparation enables absorption of 4-(2-methyl-1-imidazolyl)-2.2-dephenylbutylamide, which has a low ability to be absorbed from the skin, from the skin into the body continuously and efficiently. (1) The active ingredient content in one preparation or one time administration preparation is from about 0.1 mg to about 10 mg, (2) the size is from about 1 cmto about 300 cm.

    Abstract translation: 待解决的问题：提供一种包含4-（2-甲基-1-咪唑基）-2,2-二苯基丁基酰胺作为活性成分的经皮吸收型制剂和经皮系统的骨架，并满足至少一个 的条件（1）和（2）。 解决方案：药物制剂使得能够连续有效地从皮肤吸收具有低于皮肤吸收能力的4-（2-甲基-1-咪唑基）-2,2-脱苯基丁酰胺。 （1）一次制剂或一次给药制剂中的活性成分含量为约0.1mg至约10mg，（2）尺寸为约1cm至约1cm 300厘米 2 。 版权所有（C）2012，JPO＆INPIT

    Dry syrup preparation
    53.
    发明专利
    Dry syrup preparation 有权
    干式制剂

    公开(公告)号：JP2012067136A

    公开(公告)日：2012-04-05

    申请号：JP2012000701

    申请日：2012-01-05

    Applicant: Kyorin Pharmaceutical Co Ltd ,  杏林製薬株式会社

    Inventor： HOSHINO RYOICHI ,  NAKAJIMA TSUYOSHI ,  AOKI YOSHINOBU

    IPC: A61K31/198 ,  A61K9/00 ,  A61K9/10 ,  A61K47/10 ,  A61K47/32 ,  A61K47/38 ,  A61P11/02 ,  A61P11/10 ,  A61P11/12 ,  A61P27/16

    CPC classification number: A61K9/0095 ,  A61K31/198

    Abstract: PROBLEM TO BE SOLVED: To obtain dry syrup preparations of L-carbocysteine in which the sourness inherent to L-carbocysteine can be relieved by a more convenient production process and which can be relatively easily dispensed, are easy to carry, can be easily taken as such, can be taken by suspending or dissolving before using and can be administered to subjects over a wide range from infants to the aged.SOLUTION: By blending a sugar alcohol and a sweetener having a high sweetness, dry syrup preparations having a relieved sourness of L-carbocysteine can be obtained by a more convenient production process. The dry syrup preparations of L-carbocysteine thus obtained can be relatively easily dispensed, are easy to carry, can be easily taken as such, can be taken by suspending or dissolving before using and can be administered to subjects over a wide range from infants to the aged.

    Abstract translation: 要解决的问题：为了获得L-碳半胱氨酸的干糖浆制剂，其中L-碳半胱氨酸固有的酸可以通过更方便的制备方法缓解并且可以相对容易地分配，易于携带，可以是 容易摄取，可以在使用前悬浮或溶解使用，并且可以在从婴儿到老年人的广泛范围内给予受试者。 解决方案：通过混合具有高甜度的糖醇和甜味剂，可以通过更方便的生产方法获得具有缓解L-半胱氨酸酸性的干糖浆制剂。 由此获得的L-半胱氨酸半胱氨酸的干糖浆制剂可以相对容易地分配，易于携带，可以容易地服用，可以在使用前通过悬浮或溶解使用，并且可以在从婴儿到 老年人。 版权所有（C）2012，JPO＆INPIT

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