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    Method for quantifying dimethylaminoethyl methacrylate-containing copolymer
    61.
    发明专利
    Method for quantifying dimethylaminoethyl methacrylate-containing copolymer 有权
    定量含甲基丙烯酸二甲基丙烯酸酯共聚物的方法

    公开(公告)号：JP2011089811A

    公开(公告)日：2011-05-06

    申请号：JP2009241832

    申请日：2009-10-20

    Applicant: Kyorin Pharmaceutical Co Ltd ,  杏林製薬株式会社

    Inventor： ARIYOSHI KEIKO ,  FUKUDA MAMORU

    IPC: G01N24/08

    Abstract: PROBLEM TO BE SOLVED: To establish a method for simply quantifying a dimethylaminoethyl methacrylate-containing copolymer in a preparation without being affected by a reagent used in elution pretreatment. SOLUTION: After the preparation containing the dimethylaminoethyl methacrylate-containing copolymer is dissolved in an extraction solvent containing a surfactant and an alkylamine derivative to dry an extracted component, it is dissolved in d6-acetone containing d-trifluoroacetic acid to measure 1H-NMR to thereby quantify the dimethylaminoethyl methacrylate-containing copolymer. COPYRIGHT: (C)2011,JPO&INPIT

    Abstract translation: 要解决的问题：建立一种在制剂中简单定量含二甲基氨基乙基甲基丙烯酸酯共聚物的方法，而不受洗脱预处理中使用的试剂的影响。 解决方案：将含有含二甲基氨基乙基甲基丙烯酸酯共聚物的制剂溶解在含有表面活性剂和烷基胺衍生物的萃取溶剂中以干燥萃取的组分后，将其溶于含有D-三氟乙酸的d6-丙酮中，测量1H- NMR，从而定量含二甲氨基乙基甲基丙烯酸酯共聚物。 版权所有（C）2011，JPO＆INPIT

    Imidafenacin-containing orally disintegrating tablet
    63.
    发明专利
    Imidafenacin-containing orally disintegrating tablet 有权
    包含IMIDAFENACIN的ORALLY DISCUTING TABLET

    公开(公告)号：JP2011068640A

    公开(公告)日：2011-04-07

    申请号：JP2010189539

    申请日：2010-08-26

    Applicant: Kyorin Pharmaceutical Co Ltd ,  杏林製薬株式会社

    Inventor： ISHIZAKI TOSHIHIRO

    IPC: A61K31/4172 ,  A61K9/20 ,  A61K47/10 ,  A61K47/22 ,  A61K47/32 ,  A61K47/36 ,  A61P13/10

    Abstract: PROBLEM TO BE SOLVED: To provide a light-stable imidafenacin-containing rapidly orally disintegrating tablet. SOLUTION: The rapidly orally disintegrating tablet is prepared by mixing granules produced by spraying an excipient with imidafenacin, tocopherol or a tocopherol derivative, and at least one binder selected from the group consisting of an acrylic polymeric substance, a vinyl polymeric substance, and stearyl alcohol with an excipient and a disintegrator without subjecting to coating treatment and compression-molding the resultant mixture, wherein the content of the tocopherol or tocopherol derivative contained in the granules is 0.05-10 pts.mass per pt.mass imidafenacin, and the content of the binder is 0.1-30 pts.mass per pt.mass imidafenacin. COPYRIGHT: (C)2011,JPO&INPIT

    Abstract translation: 要解决的问题：提供一种含有光稳定的咪达那新的快速口腔崩解片。 解决方案：快速口腔崩解片剂是通过将通过喷雾赋形剂与咪达那新，生育酚或生育酚衍生物制备的颗粒和至少一种选自丙烯酸聚合物，乙烯基聚合物， 和硬脂醇与赋形剂和崩解剂反应，而不进行涂布处理和压缩成型所得混合物，其中颗粒中所含的生育酚或生育酚衍生物的含量为0.05-10质量度/每片咪达那新， 粘合剂的含量为0.1-30磅/平方米每毫升亚胺多沙星。 版权所有（C）2011，JPO＆INPIT

    Method of producing 4-(5-methylpyridine-2-ylamino)piperidine-1-carboxylic acid derivative using lewis acid
    64.
    发明专利
    Method of producing 4-(5-methylpyridine-2-ylamino)piperidine-1-carboxylic acid derivative using lewis acid 审中-公开
    使用露丝酸生产4-（5-甲基吡啶-2-基亚氨基）哌啶-1-羧酸衍生物的方法

    公开(公告)号：JP2011057594A

    公开(公告)日：2011-03-24

    申请号：JP2009207413

    申请日：2009-09-08

    Applicant: Kyorin Pharmaceutical Co Ltd ,  杏林製薬株式会社

    Inventor： KAWAMURA KOJI ,  KISHIMOTO TAKUYA

    IPC: C07D401/12 ,  B01J27/138 ,  B01J31/02 ,  C07B61/00

    CPC classification number: Y02P20/52

    Abstract: PROBLEM TO BE SOLVED: To provide a novel method of producing 5-methyl-2-(piperidine-4-ylamino)pyridine. SOLUTION: There is disclosed a production method shown in formula (in the formula, R represents a 1-6C straight chain or branched alkyl group, or an aryl 1-6C alkyl group). Namely the method of producing a 4-(5-methylpyridine-2-ylamino)piperidine-1-carboxylic acid derivative includes causing 2-amino-5-methylpyridine and a 4-piperidone-1-carboxylic acid derivative to react with each other in a solvent in the presence of a Lewis acid and a reducing agent. COPYRIGHT: (C)2011,JPO&INPIT

    Abstract translation: 待解决的问题：提供一种生产5-甲基-2-（哌啶-4-基氨基）吡啶的新方法。 解决方案：公开了式（式中，R表示1-6C直链或支链烷基或芳基1-6C烷基）所示的制备方法。 即，4-（5-甲基吡啶-2-基氨基）哌啶-1-羧酸衍生物的制备方法包括使2-氨基-5-甲基吡啶和4-哌啶酮-1-羧酸衍生物在 在路易斯酸和还原剂存在下的溶剂。 版权所有（C）2011，JPO＆INPIT

    Dimerized cyclo derivative
    68.
    发明专利
    Dimerized cyclo derivative 审中-公开
    二维循环衍生

    公开(公告)号：JP2010120851A

    公开(公告)日：2010-06-03

    申请号：JP2007030801

    申请日：2007-02-09

    Applicant: Kyorin Pharmaceut Co Ltd ,  杏林製薬株式会社

    Inventor： FUKUDA YASUMICHI ,  ASAHINA YOSHIKAZU ,  NAGATA ERI ,  MURAKAMI KOJI ,  HASE AKIKO

    IPC: C07D207/16 ,  A61K31/4025 ,  A61P3/10 ,  A61P43/00

    CPC classification number: C07D207/16

    Abstract: PROBLEM TO BE SOLVED: To provide a novel dimerized cyclo derivative having an excellent DPP-IV inhibitory activity or a pharmacologically acceptable salt thereof, and to provide a prophylactic and/or therapeutic agent for a DPP-IV-related disease which comprises the derivative or the pharmacologically acceptable salt thereof as an active ingredient. SOLUTION: There is disclosed a dimerized cyclo derivative represented by general formula (1) or a pharmacologically acceptable salt thereof (e.g., 1,2-ethanediol bis[4-[2-[(2S, 4S)-2-cyano-4-fluoropyrrolidin-1-yl]acetyl]aminobicyclo[2.2.2]octane-1-carboxylate]). COPYRIGHT: (C)2010,JPO&INPIT

    Abstract translation: 待解决的问题：提供具有优异的DPP-IV抑制活性的新型二聚环衍生物或其药理学上可接受的盐，并提供DPP-IV相关疾病的预防和/或治疗剂，其包括 其衍生物或其药理学上可接受的盐作为活性成分。 解决方案：公开了由通式（1）表示的二聚环衍生物或其药理学上可接受的盐（例如，1,2-乙二醇双[4- [2 - [（2S，4S）-2-氰基 -4-氟吡咯烷-1-基]乙酰基]氨基二环[2.2.2]辛烷-1-羧酸]）。 版权所有（C）2010，JPO＆INPIT

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