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    Terahertz wave generation device and terahertz wave measuring method
    83.
    发明专利
    Terahertz wave generation device and terahertz wave measuring method 有权
    TERAHERTZ波形发生装置和TERAHERTZ波形测量方法

    公开(公告)号：JP2014134575A

    公开(公告)日：2014-07-24

    申请号：JP2013001153

    申请日：2013-01-08

    Applicant: Arkray Inc ,  アークレイ株式会社

    Inventor： UCHIDA HIROHISA ,  SHICHI NAOTO

    IPC: G02F1/37 ,  G01N21/27 ,  G02F1/39

    CPC classification number: G02F1/3544 ,  G01N21/3581 ,  G02F1/3534 ,  G02F2001/3503 ,  G02F2001/3507 ,  G02F2203/13

    Abstract: PROBLEM TO BE SOLVED: To stably generate terahertz waves having equal characteristics in a plurality of directions.SOLUTION: Excitation light generated by a KTP-OPO 20 is made incident from a side of a first plane 12a to an optical crystal 12 via mirrors 26b, 26a, an unwanted light cut filter 28 and an off-axis parabolic mirror 26c. A terahertz wave THzis generated from a second plane 12b, excitation light transmitted through the optical crystal 12 and reflected by a concave mirror 26d is made incident from a side of the second plane 12b to the optical crystal 12, and a terahertz wave THzis generated from the first plane 12a. The terahertz waves THz, THzreflected by off-axis parabolic mirrors 32a, 32b, respectively, are transmitted through arrangement sections 40a, 40b, reflected by parabolic mirrors 42a, 42b and made incident to detectors 50a, 50b.

    Abstract translation: 要解决的问题：稳定地产生在多个方向上具有相同特性的太赫兹波。解决方案：由KTP-OPO 20产生的激发光通过反射镜26b从第一平面12a的一侧入射到光学晶体12， 26a，不需要的截止滤光器28和离轴抛物面反射镜26c。 从第二平面12b产生的太赫兹波THz从第二平面12b的一侧入射到光学晶体12，从而透射通过光学晶体12并被凹面镜26d反射的激发光从太阳波THz产生， 第一架飞机12a。 分别由离轴抛物面反射镜32a，32b反射的太赫兹THz，THz通过由抛物面镜42a，42b反射的配置部分40a，40b透射并入射到检测器50a，50b。

    Probe for detecting mutation, method of detecting mutation, method of determining drug efficacy and kit for detecting mutation
    90.
    发明专利
    Probe for detecting mutation, method of detecting mutation, method of determining drug efficacy and kit for detecting mutation 有权
    用于检测突变的检测方法，检测突变的方法，确定药物效能的方法和用于检测突变的试剂盒

    公开(公告)号：JP2014076044A

    公开(公告)日：2014-05-01

    申请号：JP2013186532

    申请日：2013-09-09

    Applicant: Arkray Inc ,  アークレイ株式会社

    Inventor： KUROSE KAORU

    IPC: C12Q1/68 ,  C12N15/09

    CPC classification number: C12Q1/6886 ,  C12Q1/6827 ,  C12Q2600/156 ,  C12Q2563/107 ,  C12Q2565/107

    Abstract: PROBLEM TO BE SOLVED: To provide a probe for detecting mutation which makes it possible to easily detect mutation in anaplastic lymphoma kinase (ALK) gene, particularly ALK (L1196M) variant and ALK (C1156Y) variant.SOLUTION: A probe for detecting mutation is at least one fluorescence-labeled oligonucleotide selected from the group of specific base sequences. A method of detecting mutation comprises (I) contacting the probe for detecting mutation and single strand nucleic acids in a sample, thereby hybridizing the fluorescence-labeled oligonucleotide and the single strand nucleic acids, and obtaining hybrids, (II) dissociating the hybrids by changing the temperature of the sample containing the hybrids and measuring the variation of fluorescent signal based on dissociation of the hybrids, (III) measuring Tm value as a dissociation temperature of the hybrids based on the variation of fluorescent signal, and (IV) detecting the presence of mutations in ALK gene in the single strand nucleic acids in the sample based on the Tm value.

    Abstract translation: 要解决的问题：提供用于检测突变的探针，其可以容易地检测变应性淋巴瘤激酶（ALK）基因，特别是ALK（L1196M）变体和ALK（C1156Y）变体中的突变。解决方案：用于检测突变的探针是 选自特定碱基序列的至少一种荧光标记的寡核苷酸。 检测突变的方法包括：（I）使探针与样品中的单链核酸接触，从而与荧光标记的寡核苷酸和单链核酸杂交，并获得杂种，（II）通过改变杂交体来解离杂种 含有杂交体的样品的温度和基于杂交体解离测量荧光信号的变化，（III）基于荧光信号的变化测量作为杂交体的解离温度的Tm值，和（IV）检测存在 基于Tm值的样品中单链核酸中的ALK基因突变。

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