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公开(公告)号：JPH06225767A
公开(公告)日：1994-08-16
申请号：JP28861793
申请日：1993-10-25
IPC分类号： A61K38/00 , A61P7/00 , C07K1/20 , C07K14/00 , C07K14/47 , C07K16/18 , C12N1/21 , C12N5/10 , C12N15/09 , C12N15/16 , C12P21/02 , C12Q1/68 , C12R1/19 , C12R1/91
摘要： PURPOSE:To obtain a new DNA useful for the production of a megakaryocyte amplifier known as an agent for the treatment of diseases relating to the thrombocytopenia or platelet hypoactivity. CONSTITUTION:A DNA containing a base sequence coding the amino acid sequence of formula, a base sequence obtained by partly substituting or depleting the above base sequence or adding a fragment to the sequence or a base sequence hybridizing to the above sequence. It can be produced by preparing an mRNA from a cell capable of producing megakaryocyte amplifier, e.g. established cell HPC-Y5 (FERM BP-3703) originated from human pancreatic carcinoma cell and converting the mRNA to double stranded cDNA by conventional method.
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公开(公告)号：JPH06133669A
公开(公告)日：1994-05-17
申请号：JP28613192
申请日：1992-10-23
IPC分类号： A01K67/027 , C07K14/575 , C12N15/09 , C12N15/85 , C12N15/52
摘要： PURPOSE:To provide a mouse lacking a function of endoserine-1 gene. CONSTITUTION:This invention is a mouse in which the function of endoserine-1 gene is removed by inserting another gene into the endoserine-1 gene. This mouse is useful, e.g. for clarification of the pathologic physiology and the cause of circulatory diseases such as hypertension, arteriosclerosis and ishemic heart disease and for development of the therapy.
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公开(公告)号：JPH06128112A
公开(公告)日：1994-05-10
申请号：JP32109992
申请日：1992-10-16
发明人： KANZAKI MITSURU , KOJIMA SHINYA , TORIO KAZUO
摘要： PURPOSE:To obtain a herbicide compound combining a specific triazole-based compound with 1-(2-chloroimidazo[1,2-a]pyridin-3-ylsulfonyl)-3-(4,6-dimethoxy-2- pyrimidyl)urea. CONSTITUTION:A triazole-based compound of formula I [R1 and R2 are alkyl, cycloalkyl, alkenyl, alkynyl or R1 and R2 form azacycloalkane with N; A is group of formula II, formula III, formula IV or formula V (X is H, alkyl, etc.; (m) is 0-3); (n) is 0-2] (especially preferably compound of formula VI) with l-[2- chloroimidazo [1,2-a]pyridin-3-ylsulfonyl]-3-(4,6-dimethoxy-2-pyrimidyl)urea of formula VII to give a herbicide composition. The composition provides a wider herbicidal spectrum than single use of each component. The composition shows extremely excellent herbicidal effect with a small amount, has no phytotoxicity to rice plant and shows synergistic effect such as maintenance of herbicidal effect for a long period of time which could never have been expected.
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公开(公告)号：JPH06121700A
公开(公告)日：1994-05-06
申请号：JP27427392
申请日：1992-10-13
发明人： YAGASAKI MITSUO , NUNOMURA KIYOTADA
摘要： PURPOSE:To well detect a hepatitis C virus at a low concentration by converting a hepatitis C virus gene RNA into a DNA, amplifying the resultant DNA and hybridizing the amplified DNA with a specific labeling DNA probe. CONSTITUTION:A hepatitis C virus gene is converted into a DNA, which is subsequently amplified. The resultant amplified DNA is then subjected to the hybridization reaction with a probe of the formula 5'- GAGACTGCTAGCCGAGT#AGTGTTGGG-3' or the formula 5'- CGCTCAATGCCT#GGAGATTTGGG-3' (acridinium N-hydroxysuccininide ester is bound through a linker to the site indicated by #). The label is subsequently detected by a hybridization.protection.assay.
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公开(公告)号：JPH0630619B2
公开(公告)日：1994-04-27
申请号：JP27212185
申请日：1985-12-03
发明人： NOMURA HITOSHI , IMAZEKI IKUO
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公开(公告)号：JPH0692958A
公开(公告)日：1994-04-05
申请号：JP32363491
申请日：1991-10-04
发明人： IWAOKA TOMOYASU , KANEKO CHIKARA , SATO MASAYUKI
IPC分类号： C07D319/06
摘要： PURPOSE:To obtain a new compound useful as an intermediate for medicines and agricultural chemicals. CONSTITUTION:The compound of formula I (R1 and R2 are 1-5C alkyl or together represent 3-6C alkylene; R3 is 1-6C alkyl, aryl or trifluoromethyl), e.g. 5-fluoro-6-methyl-4-oxo-4H-1,3-dioxin-2-spirocyclohexane. This compound of formula I is obtained by fluorinating a compound of formula II with fluorine gas, providing a difluoro derivative of formula III and then treating the resultant compound with a base such as triethylamine.
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公开(公告)号：JPH0672994A
公开(公告)日：1994-03-15
申请号：JP35436292
申请日：1992-11-27
IPC分类号： A61K31/59 , A61P3/02 , A61P5/12 , A61P29/00 , A61P35/00 , C07C401/00 , C07J7/00 , C07J51/00 , C07J71/00
摘要： PURPOSE:To efficiently obtain the new derivative for antitumor agents, antilithium agents, etc., by reacting specific hydroxypregnenes with acrylamides and then successively subjecting the reactional product to treatment with an organic metal, introduction of double bond, irradiation of ultraviolet rays and thermal isomerization reaction. CONSTITUTION:A compound of formula I (R4 is H or (protected) hydroxyl group; R5 is (protected) hydroxyl group; R6 and R7 are H or together form double bond) is made to react with acrylic amides of formula II (R8 is 1-5C dialkylamino) in an organic solvent or a water-organic solvent system to afford a compound of formula III and the compound of formula III is made to react with an organometallic compound of the formula R9X (R9 is 1-5C alkyl; X is alkali metal, alkaline earth metal halide, etc.) to give a compound of formula IV (R2 and R3 are 1-5C alkyl). Then the compound of formula IV wherein R6 and R7 are H is subjected to halogenation at allyl position and dehydrohalogenation reaction to introduce a double bond thereto and then subjected to irradiation with ultraviolet rays in an organic solvent and successively subjected to thermal isomerization to provide the objective 22- oxacholecalciferol derivative expressed by formula V (R1 is H or OH).
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公开(公告)号：JPH0615477B2
公开(公告)日：1994-03-02
申请号：JP2377785
申请日：1985-02-08
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公开(公告)号：JPH0656873A
公开(公告)日：1994-03-01
申请号：JP12451493
申请日：1993-05-26
发明人： KOGA HIROSHI , SATO TSUTOMU , TAKANASHI HISANORI
IPC分类号： C07D407/00 , C07H17/08 , A61K31/00 , A61K31/70 , A61K31/7042 , A61K31/7048 , A61P1/00 , A61P1/12 , A61P43/00
摘要： PURPOSE:To provide a new compound resistant to acid, having an extremely low decomposition rate with gastric acid by oral administration, exhibiting excellent action to promote the contraction motion of alimentary canals and useful as an agent for promoting the contraction motion of alimentary canals. CONSTITUTION:The compound of formula I [R1 is H or an acyl; R2 and R3 are H, amino, etc.; R4 is H or a lower alkyl; Y is NR5R6 or N R7R8R9X (R5 to R9 are each a lower alkyl, lower alkenyl, etc.; X is an anion)], e.g. 2'-O- acetyl-4''-O-formyl-11-oxo-8,9-anhydroerythromycin A6,9-hemiketal. The compound can be produced e.g. by oxidizing a compound of formula II with an oxidizing agent such as chromic acid and manganese oxide and alkylating the product with an alkylation agent such as alkyl halide and acrylic acid derivative in an inert solvent.
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公开(公告)号：JPH0656817A
公开(公告)日：1994-03-01
申请号：JP20897791
申请日：1991-05-16
发明人： IWAOKA TOMOYASU , OCHI KIYOSHIGE , KANEKO CHIKARA , SATO MASAYUKI
IPC分类号： C07C69/716 , C07C69/732 , C07D239/553 , C07D319/06
摘要： PURPOSE:To provide a new 5-trifluoromethyl-1,3-dioxin-4-one derivative useful as an intermediate for 5-trifluoromethyluracil derivative useful as an antitumor agent or an antiviral agent or an intermediate raw material for other medicines, agricultural chemicals, etc. CONSTITUTION:The 5-trifluoromethyl-1,3-dioxin-4-one derivative of formula I (R1 and R2 are each a 1-5C alkyl or R1 and R2 together form a 3-6C alkylene; R3 is H, 1-6C alkyl or aryl), e.g. 4-oxo-5-trifluoromethyl-4H-1,3-dioxin-2- spirocyclohexane. This compound of formula I is obtained by reacting a compound of formula II (X is a halogen) with a trifluoromethylcopper in an inert solvent. Furthermore, this compound of formula I is made to react with a urea derivative to afford a 5-trifluoromethyluracil derivative useful as an antitumor agent or an antiviral agent in a high yield.
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