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公开(公告)号：JP6595196B2
公开(公告)日：2019-10-23
申请号：JP2015066919
申请日：2015-03-27
Applicant: 国立大学法人三重大学 , 国立大学法人静岡大学 , 株式会社岩出菌学研究所
IPC: A61K31/575 , A61K31/58 , A61K45/00 , A61P37/08 , A61K36/07
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公开(公告)号：JP2011102286A
公开(公告)日：2011-05-26
申请号：JP2010101510
申请日：2010-04-26
Applicant: Iwade Kingaku Kenkyusho:Kk , 株式会社岩出菌学研究所
Inventor： SAITO MASAYOSHI , HARADA ETSUKO , ASHIDA HITOSHI , MIZUNO MASAFUMI
Abstract: PROBLEM TO BE SOLVED: To provide a composition effective for preventing or eliminating obesity or lowering blood glucose level. SOLUTION: There are provided (1) a composition containing a hot water extract from mushrooms belonging to the genus Grifola frondosa, Polyporaceae, Aphyllophorales, Basidiomycetes; (2) a composition containing a low molecular fraction obtained by separating a hot water extract from mushrooms belonging to the genus Grifola frondosa, Polyporaceae, Aphyllophorales, Basidiomycetes with a separation membrane having one in a fraction mol.wt. range of 30,000 to 10,000; and (3) a composition containing ergothioneine, a pharmacologically acceptable salt thereof, or a compound which is hydrolyzed to produce the ergothioneine, as a fat-reducing activity ingredient. COPYRIGHT: (C)2011,JPO&INPIT
Abstract translation: 待解决的问题：提供有效预防或消除肥胖或降低血糖水平的组合物。 提供了（1）含有来自蘑菇属（Grifola frondosa），多孢属（Polyporaceae），叶绿茶（Aphyllophorales），担子菌纲（Basyliomycetes））的蘑菇的热水提取物的组合物。 （2）一种含有低分子级分的组合物，其通过用具有分数摩尔重量百分比的分离膜分离来自属于Grifola frondosa，Polyporaceae，Aphyllophorales，担子菌的蘑菇的热水提取物而获得。 范围在30,000至10,000; 和（3）含有麦角硫素的组合物，其药理学上可接受的盐或水解产生麦角硫素的化合物作为减脂活性成分。 版权所有（C）2011，JPO＆INPIT
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公开(公告)号：JP2008173041A
公开(公告)日：2008-07-31
申请号：JP2007008411
申请日：2007-01-17
Applicant: Iwade Kingaku Kenkyusho:Kk , Nomura Kazuyo , 株式会社岩出菌学研究所 , 野村 和世
Inventor： HARADA ETSUKO , NISHIOKA HIROKI , KAWADE MITSUO
IPC: A01G1/04
Abstract: PROBLEM TO BE SOLVED: To provide a method for easily obtaining artificially cultivated mushroom having high vitamin D content.
SOLUTION: A method for increasing vitamin D content of mushroom includes forming primordia through giving mushroom hypha stimulation, and continuing to irradiate visible light of an illumination intensity of 300-900 lux, preferably 400-800 lux until harvest of carpophores after primordium formation. The stimulation for forming primordia may be irradiation with visible light of an illumination intensity of 300-900 lux. The wavelength of visible light is 400-780 nm. The method is suitable especially for mushroom belonging to basidiomycete Homobasidiomycetes.
COPYRIGHT: (C)2008,JPO&INPITAbstract translation: 待解决的问题：提供一种容易获得维生素D含量高的人造栽培蘑菇的方法。 解决方案：增加蘑菇维生素D含量的方法包括通过产生蘑菇菌丝刺激形成原基，并继续照射300-900勒克司，优选400-800勒克司他的照明强度的可见光，直到原始基因收获后 形成。 用于形成原基的刺激可以是照射强度为300-900勒克司的可见光照射。 可见光的波长为400-780nm。 该方法尤其适用于担子担子菌的菌种。 版权所有（C）2008，JPO＆INPIT
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公开(公告)号：JP2020029426A
公开(公告)日：2020-02-27
申请号：JP2018156398
申请日：2018-08-23
Applicant: 株式会社岩出菌学研究所 , 国立大学法人三重大学 , 国立大学法人静岡大学 , 国立大学法人名古屋大学
IPC: A61P35/00 , A61P43/00 , A61P37/04 , A61K31/352 , A61K31/12 , A61K31/09 , A61K31/235 , A61K31/215 , A61K36/07
Abstract: 【課題】免疫チェックポイント分子等の免疫系で抑制的に作用するタンパク質に対して阻害的に作用し、癌に対する免疫能を向上させることができる天然由来の成分を提供する。 【解決手段】ヤマブシタケ(Hericium erinaceum)抽出物、ナラタケ(Armillaria sp.)抽出物、及び/又は茶樹茸(Agrocybe chaxingu)抽出物を有効成分として含有する、抗癌剤耐性抑制剤を提供する。 【選択図】なし
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公开(公告)号：JP5658487B2
公开(公告)日：2015-01-28
申请号：JP2010131045
申请日：2010-06-08
Applicant: 株式会社岩出菌学研究所
IPC: A61K36/07 , A61K31/353 , A61P35/00 , A61P43/00
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Patent Agency Ranking
公开(公告)号：JP2009051793A
公开(公告)日：2009-03-12
申请号：JP2007222333
申请日：2007-08-29
Applicant: Iwade Kingaku Kenkyusho:Kk , Nomura Kazuyo , 株式会社岩出菌学研究所 , 野村 和世
Inventor： KAWAGISHI HIROKAZU , YAZAWA KAZUYOSHI , HARADA ETSUKO
IPC: A61K31/575 , A61P19/08 , A61P19/10 , A61P43/00 , C07J9/00
Abstract: PROBLEM TO BE SOLVED: To specify a compound existing in the fruit body of Grifola gargal and exhibiting osteoclast formation suppressing effect and provide the compound as a therapeutic agent for bone diseases.
SOLUTION: The therapeutic agent for bone diseases comprises one or more compounds selected from a group consisting of 3β, 5α-dihydroxyergosta-7, 22-dien-6-one, cerevisterol, and pharmaceutically acceptable salts of the compounds as active components.
COPYRIGHT: (C)2009,JPO&INPITAbstract translation: 要解决的问题：指定存在于Grifola gargal的果实体中的化合物并显示破骨细胞形成抑制作用，并提供该化合物作为骨疾病的治疗剂。 解决方案：骨疾病治疗剂包含一种或多种选自3β，5α-二羟基麦角甾-7,22-二烯-6-酮，cerevisterol的化合物和作为活性成分的化合物的药学上可接受的盐 。 版权所有（C）2009，JPO＆INPIT
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公开(公告)号：JP2008099587A
公开(公告)日：2008-05-01
申请号：JP2006284200
申请日：2006-10-18
Applicant: Iwade Kingaku Kenkyusho:Kk , 株式会社岩出菌学研究所
Inventor： HARADA ETSUKO , SUMITANI TOSHIMITSU
Abstract: PROBLEM TO BE SOLVED: To provide a Grifola gargal's mycelium cultured product ameliorating immunoactivity, cholesterol value, particularly arteriosclerosis index. SOLUTION: The Grifola gargal's mycelium cultured product is such as to be obtained by culturing Grifola gargal's mycelia followed by drying and then grinding the resulting product. Specifically, this product is obtained by culturing Grifola gargal's mycelia under air dispersion or ventilation, evaporating most of moisture from the resulting product at 40-50°C for about 24 h and then drying the product at 60-80°C for about one hour. This Grifola gargal's mycelium cultured product has carcinostatic activity or immunoactivity, and blood cholesterol level-lowering activity or arteriosclerosis index-lowering activity. COPYRIGHT: (C)2008,JPO&INPIT
Abstract translation: 要解决的问题：提供Grifola gargal的菌丝体培养产物改善免疫活性，胆固醇值，特别是动脉硬化指数。 解决方案：Grifola gargal的菌丝体培养产物通过培养Grifol gargal菌丝体获得，然后干燥，然后研磨所得产物。 具体地说，该产品通过在空气分散或通风下培养Grifol gargal的菌丝体而获得，从40-50℃将所得产物的大部分水分蒸发约24小时，然后在60-80℃干燥约1小时 。 这种Grifola gargal的菌丝体培养产物具有制癌活性或免疫活性，以及血液胆固醇降低活性或动脉硬化指数降低活性。 版权所有（C）2008，JPO＆INPIT
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公开(公告)号：JP2007020560A
公开(公告)日：2007-02-01
申请号：JP2006059499
申请日：2006-03-06
Applicant: Iwade Kingaku Kenkyusho:Kk , 株式会社岩出菌学研究所
Inventor： HARADA ETSUKO , NISHIOKA HIROKI , SUMITANI TOSHIMITSU
CPC classification number: Y02P20/52
Abstract: PROBLEM TO BE SOLVED: To artificially cultivate Grifola gargal that naturally grows in Chile and Argentina in South America, has peculiar fragrance and has been locally relished, thereby supplying the plant in large quantities as a food material. SOLUTION: A method for artificially cultivating Grifola gargal comprises: the first step of inoculating a medium with Grifola gargal's spawns and culturing them into mycelia; the second step of subjecting the mycelia to light irradiation and/or low-temperature stimulation at the stage of suddenly decreasing in the benzaldehyde content of the mycelia to form anlagen; and the third step of culturing the anlagen to form Grifola gargal's carpophore; and preferably, the fourth step of continuing the culture for 20-50 h in such a condition that the carbon dioxide concentration and humidity in the culturing ambience are raised. The Grifola gargal thus cultivated has ITS-1(internal transcribed spacer-1) described in the Sequence table 1 and ITS-2 described in the Sequence table 2, has ITS-1 described in the Sequence table 3 and ITS-2 described in the Sequence table 4, has ITS-1 described in the Sequence table 5 and ITS-2 described in the Sequence table 6, or emits benzaldehyde-based fragrance. COPYRIGHT: (C)2007,JPO&INPIT
Abstract translation: 要解决的问题：为了人工培养在南美洲智利和阿根廷自然生长的Grifola gargal，具有独特的香味，并被局部享用，从而大量供应植物作为食品。 解决方案：人工栽培三叶草的方法包括：将Grifol gargal的产物接种培养基的第一步，并将其培养成菌丝体; 在菌丝体的苯甲醛含量突然降低的阶段使菌丝体经受光照射和/或低温刺激的第二步骤，以形成成纤维细胞; 第三步培养天然草地，形成Grifola gargal的carpophore; 优选在培养环境中的二氧化碳浓度和湿度升高的条件下继续培养20-50小时的第四步骤。 由此栽培的Grifola gargal具有序列表1中描述的ITS-1（内转录间隔物-1）和序列表2中所述的ITS-2，其具有序列表3中描述的ITS-1和 序列表4具有序列表5中描述的ITS-1和序列表6中所述的ITS-2，或者发出苯甲醛类香料。 版权所有（C）2007，JPO＆INPIT
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公开(公告)号：JP2004359645A
公开(公告)日：2004-12-24
申请号：JP2003163141
申请日：2003-06-09
Applicant: Hitoshi Ito , Iwade Kingaku Kenkyusho:Kk , 伊藤 均 , 株式会社岩出菌学研究所
Inventor： ITO HIROKO , ITO HITOSHI , SUMITANI TOSHIMITSU
Abstract: PROBLEM TO BE SOLVED: To provide a new anti-arteriosclerotic agent containing a water-soluble composite component or protein polysaccharide complex component separated from the fruit body of Agaricus blazei and/or its treated product. SOLUTION: A water-soluble composite component or protein polysaccharide complex component separated from the fruit body of Agaricus blazei and/or its treated product is used as an active component of the anti-arteriosclerotic agent. COPYRIGHT: (C)2005,JPO&NCIPI
Abstract translation: 要解决的问题：提供一种新的抗动脉硬化剂，其含有从姬松茸的果实体和/或其处理的产品分离的水溶性复合组分或蛋白质多糖复合物成分。 解决方案：将与姬松茸和/或其处理产物的果实体分离的水溶性复合成分或蛋白多糖复合成分用作抗动脉硬化剂的活性成分。 版权所有（C）2005，JPO＆NCIPI
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