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    Lipase inhibitor
    1.
    发明专利
    Lipase inhibitor 有权
    脂肪酶抑制剂

    公开(公告)号：JP2005320323A

    公开(公告)日：2005-11-17

    申请号：JP2005111714

    申请日：2005-04-08

    申请人： Taisho Pharmaceut Co Ltd ,  大正製薬株式会社

    发明人： ISHIBE MASUMI ,  ASANO TOSHIKI ,  MORITO AKIHISA

    IPC分类号： A61K36/73 ,  A61K36/07 ,  A61K36/18 ,  A61K36/23 ,  A61K36/28 ,  A61K36/29 ,  A61K36/48 ,  A61K36/53 ,  A61P3/04 ,  A61P3/06 ,  A61P43/00 ,  A61K35/78 ,  A61K35/84

    摘要： PROBLEM TO BE SOLVED: To provide a lipase inhibitor which is safe and effective, even when continuously administered for a long period. SOLUTION: This lipase inhibitor is characterized by compounding one or more materials selected from the group consisting of Chaenomeles speciosa, Rubus chingii, R. crataegifolius, R. coreanus and R. parvifolius; an Epimedium plant such as Epimedium sagittatum or E. grandiflorum; Polygala tenuifolia, Desmodium styracifolium, Viola mandshurica or V. japonica; Elfvingia applanata or Phellinus igniarius; Magnolia biondii, M. liliflora or M. salicifolia; Artemisia capillaries or A. iwayomogi; Notopterygium incisum, N. forbesii or N. forbesii var. oviforme; Pogostemon cablin or Agastache rugosa; Artemisia argyi, A. princeps, A. lavandulaefolia, or A. Montana; Caesalpinia sappan; Psoralea corylifolia; and Perilla frutescens. Since this galenical has an excellent lipase-inhibiting action, the galenical can be used for medicines for treating or preventing lipase-originating diseases such as hyperlipemia or obesity, and for foods, and the like. COPYRIGHT: (C)2006,JPO&NCIPI

    摘要翻译： 要解决的问题：即使连续施用长时间，提供安全有效的脂肪酶抑制剂。 解决方案：该脂肪酶抑制剂的特征在于配合选自木瓜属（Cheenomeles speciosa），木槿（Rubus chingii），，草（R. crataegifolius），核心，（R.cakanusus）和小曲霉（Parvifolius） 淫羊藿植物如淫羊藿或大花um; 茯苓，丝，，中华堇或粳稻; 小灵芝或桑黄; 玉兰di i，;;;;;;;;;; 艾蒿毛细血管或A.Iwayomogi; ium藜，N.forbesii或N.forbesii var。 oviforme; Pogostemon cablin或Agastache rugosa; 艾蒿，A. ps，l ia，或A.蒙大拿; Caesalpinia sappan; 茯苓 和紫苏。 由于该含醋酸酯具有优异的脂肪酶抑制作用，所以盖仑液可用于治疗或预防脂肪酶来源疾病如高脂血症或肥胖症的药物，以及食品等。 版权所有（C）2006，JPO＆NCIPI

    Hypotensive agent containing pentitol or hexitol as active ingredient
    2.
    发明专利
    Hypotensive agent containing pentitol or hexitol as active ingredient 有权
    含有PENTITOL或HEXITOL作为活性成分的HYPOTENSIVE AGENT

    公开(公告)号：JP2005306775A

    公开(公告)日：2005-11-04

    申请号：JP2004125370

    申请日：2004-04-21

    申请人： Three-B Co Ltd ,  株式会社スリービー

    发明人： YOSHINARI ATSUSHIRO

    IPC分类号： C12N9/99 ,  A61K31/047 ,  A61K36/07 ,  A61P9/12 ,  A61P43/00 ,  A61K35/84

    摘要： PROBLEM TO BE SOLVED: To obtain a new ACE inhibitor having extremely high safety, and a new hypotensive agent having extremely high safety. SOLUTION: The ACE (angiotensin converting enzyme) inhibitor contains a pentitol or a hexitol as an active ingredient. The most preferable active ingredients are mannitol and xylitol. Also, the ACE inhibitor and the hypotensive agent each contains the extract of Pleurotus comucopiae as an active ingredient. The ACE inhibitor does not has toxicity, does not affect living bodies, even when taken in a large amount, and furthermore has other advantages. COPYRIGHT: (C)2006,JPO&NCIPI

    摘要翻译： 要解决的问题：获得具有极高安全性的新型ACE抑制剂和具有极高安全性的新型降压药。 ACE（血管紧张素转换酶）抑制剂含有戊糖醇或己糖醇作为活性成分。 最优选的活性成分是甘露醇和木糖醇。 此外，ACE抑制剂和降血压药剂各自含有作为活性成分的侧耳属（Pleurotus comucopiae）的提取物。 ACE抑制剂没有毒性，即使大量服用也不影响活体，另外还有其它优点。 版权所有（C）2006，JPO＆NCIPI

    Hepatic fibrosis inhibitory agent
    3.
    发明专利
    Hepatic fibrosis inhibitory agent 审中-公开
    肝纤维化抑制剂

    公开(公告)号：JP2005239699A

    公开(公告)日：2005-09-08

    申请号：JP2004093129

    申请日：2004-03-26

    申请人： Kobayashi Pharmaceut Co Ltd ,  Nagaoka Hitoshi ,  小林製薬株式会社 ,  長岡 均

    发明人： YAGI KIYOHITO ,  KAWASE MASAYA ,  WATANABE AIKO ,  TAMESADA MAKOTO

    IPC分类号： A23L1/30 ,  A61K31/05 ,  A61K36/07 ,  A61P1/16 ,  A61P31/12 ,  A61P35/00 ,  A61K35/84

    CPC分类号： A61K31/05 ,  A23L33/10 ,  A61K36/07

    摘要： PROBLEM TO BE SOLVED: To provide an effective preventing or treating means for hepatic fibrosis, and also to obtain a hepatic fibrosis inhibitory agent capable of becoming the treating means, a medicinal composition, a food and drink. SOLUTION: This hepatic fibrosis inhibitory agent contains a shiitake mushroom (Lentinus edodes) mycelia extract or its fractionated substance. A hepatic protecting agent having the effect of inhibiting the hepatic fibrosis contains the shiitake mushroom mycelia extract or its fractionated substance. Also, the medicinal composition, food, beverage, and the like, containing the fractionated substance are provided. COPYRIGHT: (C)2005,JPO&NCIPI

    摘要翻译： 要解决的问题：提供肝纤维化的有效预防或治疗手段，以及获得能够成为治疗手段的肝纤维化抑制剂，药物组合物，食品和饮料。 解决方案：该肝纤维化抑制剂含有香菇（Lentinus edodes）菌丝体提取物或其分馏物质。 具有抑制肝纤维化作用的肝保护剂含有香菇菌丝体提取物或其分馏物。 此外，还提供含有分级物质的药物组合物，食品，饮料等。 版权所有（C）2005，JPO＆NCIPI

    Cyathane derivative and antibacterial agent containing the derivative as active component
    4.
    发明专利
    Cyathane derivative and antibacterial agent containing the derivative as active component 有权
    含有衍生物作为活性成分的氰基衍生物和抗菌剂

    公开(公告)号：JP2005239669A

    公开(公告)日：2005-09-08

    申请号：JP2004053849

    申请日：2004-02-27

    申请人： Yukito Akiyama ,  Hirokazu Kawagishi ,  Tomoyuki Nakamura ,  友幸 中村 ,  洋和 河岸 ,  幸仁 秋山

    发明人： KAWAGISHI HIROKAZU ,  NAKAMURA TOMOYUKI ,  AKIYAMA YUKITO ,  TOKUYAMA SHINJI

    IPC分类号： C07H7/06 ,  A61K36/07 ,  A61P31/04 ,  A61K35/84

    CPC分类号： Y02A50/473

    摘要： PROBLEM TO BE SOLVED: To provide a cyathane derivative (named as erinacineJ) and an antibacterial agent containing the derivative as an active component, especially an antibacterial agent effective against MRSA (methicillin resistant Staphylococcus aureus). SOLUTION: The invention provides (1) a cyathane derivative expressed by structural formula, (2) an antibacterial agent containing the cyathane derivative as an active component and (3) an antibacterial agent for MRSA containing the cyathane derivative as an active component. COPYRIGHT: (C)2005,JPO&NCIPI

    摘要翻译： 要解决的问题：提供一种细胞因子衍生物（命名为erinacineJ）和含有该衍生物作为活性成分的抗菌剂，特别是抗MRSA（耐甲氧西林金黄色葡萄球菌）的抗菌剂。 解决方案：本发明提供（1）由结构式表示的星形衍生物衍生物，（2）含有胞苷衍生物作为活性成分的抗菌剂，（3）含有胞苷衍生物作为活性成分的MRSA抗菌剂 。 版权所有（C）2005，JPO＆NCIPI

    Agent for inhibiting increase of blood glucose level
    6.
    发明专利
    Agent for inhibiting increase of blood glucose level 有权
    用于抑制血液葡萄糖水平升高的药剂

    公开(公告)号：JP2005213211A

    公开(公告)日：2005-08-11

    申请号：JP2004022752

    申请日：2004-01-30

    申请人： Noda Shokukin Kogyo Kk ,  野田食菌工業株式会社

    发明人： HIBINO YASUHIDE ,  IIZUKA HIROSHI ,  OHASHI YASUHIRO

    IPC分类号： A61K36/899 ,  A61K36/00 ,  A61K36/07 ,  A61P3/10 ,  A61K35/78 ,  A61K35/84

    摘要： PROBLEM TO BE SOLVED: To obtain an agent for inhibiting the increase of a blood glucose level, capable of readily and safely inhibiting the increase of the blood glucose level in the blood by daily administration. SOLUTION: The agent for inhibiting the increase of the blood glucose level contains a component obtained by culturing a mycelium of basidiomycete such as a shelf fungus and a shiitake mushroom (hentinus edodes) by using a medium containing rice bran, a vegetable fiber-based raw material, preferably, a plant of true grasses, more preferably, at least one kind selected from bagasse, a stalk and phyllome of bamboo grass, and a stem of corn, and extracting the obtained cultured product as an active ingredient. COPYRIGHT: (C)2005,JPO&NCIPI

    摘要翻译： 待解决的问题：为了获得抑制血糖水平升高的药剂，能够通过日常给药容易且安全地抑制血液中的血糖水平升高。 解决方案：用于抑制血糖水平升高的药剂含有通过使用含有米糠，植物纤维的培养基培养担子菌菌丝体如棚架和香菇（hentinus edodes）获得的成分 优选为真草植物，更优选选自甘蔗渣，竹草茎，叶茎和玉米茎中的至少一种，提取得到的培养物为活性成分。 版权所有（C）2005，JPO＆NCIPI

    Inhibitor of colon cancer and food containing the same
    7.
    发明专利
    Inhibitor of colon cancer and food containing the same 有权
    结肠癌和含有其的食物的抑制剂

    公开(公告)号：JP2005187392A

    公开(公告)日：2005-07-14

    申请号：JP2003430388

    申请日：2003-12-25

    申请人： Nippon Beet Sugar Mfg Co Ltd ,  Nippon Flour Mills Co Ltd ,  日本甜菜製糖株式会社 ,  日本製粉株式会社

    发明人： HAZAMA KAZUHIKO ,  KINOSHITA MIKIAKI ,  ONISHI MASAO ,  ONO JISABURO ,  TAMURA MASAHIKO

    IPC分类号： A23L1/30 ,  A61K36/06 ,  A61K36/07 ,  A61P1/00 ,  A61P35/00 ,  A61K35/70 ,  A61K35/72 ,  A61K35/84

    摘要： PROBLEM TO BE SOLVED: To provide an active ingredient highly safe in administration to a human body, and exhibiting excellent bioactive effects; and to provide a food containing the active ingredient. SOLUTION: The inhibitor of colon cancer contains a glucosylceramide fraction extracted from true fungi as the active ingredient. Preferably, the true fungi are selected from a yeast, a mold and a mushroom in the inhibitor of the colon cancer. The inhibitor of the colon cancer prevents the onset of the colon cancer. The food is obtained by formulating the inhibitor of the colon cancer. COPYRIGHT: (C)2005,JPO&NCIPI

    摘要翻译： 要解决的问题：提供对人体施用高度安全的活性成分，并表现出优异的生物活性作用; 并提供含有活性成分的食品。 解决方案：结肠癌抑制剂含有从真菌提取的葡萄糖神经酰胺部分作为活性成分。 优选地，真菌真菌选自结肠癌抑制剂中的酵母，霉菌和蘑菇。 结肠癌的抑制剂可防止结肠癌的发生。 通过配制结肠癌的抑制剂获得食物。 版权所有（C）2005，JPO＆NCIPI

    Aqueous alkaline solution for supplementing mineral, method for producing the same and composition for preventing and improving osteoporosis by using the same
    8.
    发明专利
    Aqueous alkaline solution for supplementing mineral, method for producing the same and composition for preventing and improving osteoporosis by using the same 审中-公开
    用于补充矿物质的碱性碱溶液，其制备方法和使用该组合物预防和改善骨质疏松的组合物

    公开(公告)号：JP2005104953A

    公开(公告)日：2005-04-21

    申请号：JP2003403769

    申请日：2003-09-30

    申请人： Jinju Bio Food Kk ,  ジンジュバイオフード株式会社

    发明人： SUNG-RYONG HWA ,  YONG-CHOL JONG ,  SEN SONSHIKU ,  SO ZONGON ,  GAN SHINGON

    IPC分类号： A23L1/30 ,  A23L1/304 ,  A61K31/19 ,  A61K31/194 ,  A61K31/202 ,  A61K35/32 ,  A61K35/56 ,  A61K36/02 ,  A61K36/07 ,  A61K36/18 ,  A61K36/23 ,  A61K36/48 ,  A61K36/71 ,  A61K36/73 ,  A61K38/17 ,  A61P3/02 ,  A61P19/10 ,  A61K35/78 ,  A61K35/80 ,  A61K35/84

    摘要： PROBLEM TO BE SOLVED: To prepare an aqueous alkaline solution for supplementing minerals, containing the large amounts of inorganic substances such as calcium, magnesium, phosphorus, sodium, potassium, zinc, which are necessary for a human body, and to provide a method for producing the same. SOLUTION: The aqueous alkaline solution for supplementing minerals is constituted by adding an organic acid obtained by using bovine bones, cuttlefish shells and red algae as raw materials to an aqueous mineral solution containing the large amounts of inorganic substances such as calcium, magnesium, phosphorus, sodium, potassium, zinc, to obtain an alkaline mineral solution, and also containing a crude drug composition, dried cod roe, black bean, dentinus edodes, casein phospeptide and docosahexenoic acid. The method for producing the same, a composition and a health food having preventing and improving effects on osteoporosis by utilizing the alkali solution for supplementing the minerals are provided. COPYRIGHT: (C)2005,JPO&NCIPI

    摘要翻译： 要解决的问题：为了制备含有大量人体必需的钙，镁，磷，钠，钾，锌的大量无机物质的矿物质的碱性水溶液，并提供 其制造方法。 解决方案：用于补充矿物质的碱性水溶液是通过将以牛骨，墨鱼壳和红藻为原料得到的有机酸加入到含有大量无机物质如钙，镁的矿物溶液中构成的。 ，磷，钠，钾，锌，得到碱性矿物质溶液，还含有生药组合物，干鳕鱼，黑豆，牙本质，酪蛋白磷酸和二十二碳六烯酸。 提供了其制备方法，通过利用碱溶液补充矿物质来预防和改善对骨质疏松症的影响的组合物和保健食品。 版权所有（C）2005，JPO＆NCIPI