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    ORAL ADMINISTRATION AGENT, BEVERAGE AND FOOD HAVING ANTI-CANCER ACTIVITY
    2.
    发明专利
    ORAL ADMINISTRATION AGENT, BEVERAGE AND FOOD HAVING ANTI-CANCER ACTIVITY 失效

    公开(公告)号：JPH06128164A

    公开(公告)日：1994-05-10

    申请号：JP30469892

    申请日：1992-10-16

    申请人： ITO HITOSHI ,  IWADE KINGAKU KENKYUSHO KK

    发明人： ITO HITOSHI ,  SUMITANI TOSHIMITSU

    IPC分类号： A23L1/28 ,  A23L1/30 ,  A61K31/715 ,  A61K36/07 ,  A61P35/00 ,  C08B37/00 ,  A61K35/84

    摘要： PURPOSE:To provide an oral administration agent and a beverage or food exhibiting an excellent anti-cancer activity by its oral administration, and having the truly convenient anti-cancer activity on its concrete use. CONSTITUTION:The oral administration agent having the anti-cancer activity contains as an active ingredient a high molecular polysaccharide composite component obtained by extracting an extraction residue with hot water, the extraction residue being obtained by extracting off the characteristic smell ingredients and colorants of Agaricus blazei from the fruit bodies of the Agaricus blazei, its ground product or its dried product with an organic solvent or water-containing organic solvent. The beverage or food contains the high molecular polysaccharide composite component contained in the extraction residue obtained by extracting off the characteristic smell ingredient and the colorant of the Agaricus blazei from the fruit bodies of the Agaricus blazei, its ground product or its dried product with the organic solvent or water- containing organic solvent.

    SIMPLE GLUCAN SEPARATED FROM CULTURED CHORAY* PREPARATION THEREOF AND ANTITUMOR AGENT CONTAINING ITS POLYSACCHARIDE AS EFFECTIVE COMPONENT
    7.
    发明专利
    SIMPLE GLUCAN SEPARATED FROM CULTURED CHORAY* PREPARATION THEREOF AND ANTITUMOR AGENT CONTAINING ITS POLYSACCHARIDE AS EFFECTIVE COMPONENT 失效

    公开(公告)号：JPS5676401A

    公开(公告)日：1981-06-24

    申请号：JP15315979

    申请日：1979-11-27

    申请人： ITO HITOSHI ,  HIDAKA HIROYOSHI

    发明人： ITOU HITOSHI ,  HIDAKA HIROYOSHI ,  MIYAZAKI TOSHIO ,  SHIMURA KEISHIROU ,  YAHAGI NOBUO

    IPC分类号： C08B37/00 ,  A61K31/715 ,  A61P35/00 ,  C12P19/04 ,  C12R1/645

    摘要： NEW MATERIAL:Titled simple glucan wherein two to three beta-1,6-bonded glucose molecules are bonded to the main chain by beta-1,6-bond per two beta-1,3-glucoxide- bonded glucose units constituting the main chain. USE:Antitumor agent, prophilactic against infectious diseases such as hepatitis and pneumonia, caused by viral or bacterial infection resulting from the decline of physical stamina or immunity strength. PREPARATION:Cultured mycelia of Choray Basidiomycetes [FERM-P5237(GU- 10)] are extracted with hot water. The extract is purified and concentrated by filtration, dialysis, etc., and mixed with a precipitant such as ethanol thereby to yield crude polysaccharide. Then, to the crude polysaccharide is added a quat. ammonium salt to precipitate impurities. To the resulting supernatant liquid is added a precipitant to precipitate purified polysaccharide. Next, this purified polysaccharide is dissolved in water and fractionated, for example, by gel filtration to yield simple glucan having the structure represented by the formula.

    POLYSACCHARIDEEPOLYPEPTIDE COMBINATION HAVING BETA*113** *116* GLUCAN STRUCTURE AND ITS PREPARATION
    9.
    发明专利
    POLYSACCHARIDEEPOLYPEPTIDE COMBINATION HAVING BETA*113** *116* GLUCAN STRUCTURE AND ITS PREPARATION 失效

    公开(公告)号：JPS5578001A

    公开(公告)日：1980-06-12

    申请号：JP15127578

    申请日：1978-12-06

    申请人： ITO HITOSHI ,  HIDAKA HIROYOSHI

    发明人： ITOU HITOSHI ,  HIDAKA HIROYOSHI ,  SUGIURA MAMORU

    IPC分类号： C08B37/00

    摘要： PURPOSE:To obtain the title novel compound useful as oral antitumor, liver function improving, antidepressive, and antihyperlipemia drugs, by reacting the reaction product between a specific polysaccharide and a cyanogen halide with a polypeptide. CONSTITUTION:The hydroxyl group in the side chain or cleaved terminal glucose ring of the (1-6) bond in (A) a polysaccharide, D-11 of the formula I or its derivative, obtained from mycelia is reacted with (B) a cyanogen halide or perhalogenate. (C) A polypeptide having terminal amino groups, e.g. bovine serum albumin, is reacted with the reaction product thus obtained to give the objective compound. The component (A) is preferably prepared by extracting and purifying a cultured mycelia of Ceriolus Versicolor IWADE.

    PREPARATION OF PROTEIN POLYSACCHARIDE HAVING ANTIITUMOR ACTIVITY
    10.
    发明专利
    PREPARATION OF PROTEIN POLYSACCHARIDE HAVING ANTIITUMOR ACTIVITY 失效

    公开(公告)号：JPS5574797A

    公开(公告)日：1980-06-05

    申请号：JP14982878

    申请日：1978-12-04

    申请人： MITSUBISHI YUKA YAKUHIN KK ,  ITO HITOSHI

    发明人： ITOU HITOSHI ,  SHIMURA KEISHIROU ,  NARUSE SENSUKE ,  IWADE INOSUKE ,  SAI TOSHIYUKI

    IPC分类号： C12P19/04 ,  A61K31/715 ,  A61P35/00 ,  C12R1/645

    摘要： PURPOSE:To prepare a protein polysaccharide having remarkable anti-tumor activity, by extracting fruit bodies of a novel fungus belonging to Agaricus genus, with an aqueous medium. CONSTITUTION:Crushed fruit bodies of a novel fungus, Agricus heterosistes Heinem. et Goose (FERM-P No.4731) are extracted with 2-10 times volume of an aqueous medium at 50-100 deg.C for about 1-10 hours. The extract is added with an water-soluble organic solvent such as alcohol or acetone, or with a salt such as calcium chloride. The precipitate is filtered or centrifuged, washed with ether, and dried to obtain the objective substance in powder form. The substance is pale gray powder, and 1% aqueous solution thereof exhibits pH6.0. Color reactions: positive to anthrone sulfate reaction, phenol sulfate reaction, etc.; negative to orcinol reaction.