公开(公告)号：JP4555981B2

公开(公告)日：2010-10-06

申请号：JP2002542417

申请日：2001-11-13

申请人： ユーランド ソシエタ ペル アチオニ

发明人： マイオ・マリオ

IPC分类号： C12N9/98 ,  A61K9/08 ,  A61K9/10 ,  A61K9/14 ,  A61K9/16 ,  A61K9/20 ,  A61K9/48 ,  A61K9/50 ,  A61K38/43 ,  A61K38/46 ,  A61K47/30 ,  A61K47/34 ,  A61P1/14 ,  A61P1/16 ,  A61P1/18 ,  A61P11/00 ,  A61P35/00

CPC分类号： A61K9/50 ,  A61K9/1641 ,  A61K9/5047 ,  A61K38/54 ,  C12N11/08

摘要： The present invention refers to new microspheres including pancreatic enzymes, pharmaceutical compositions containing them, and a process to obtain them. The process here described doesn't involve the use of solvents and proves to be remarkably shorter and efficient than the producing methods of the prior arts. The microspheres obtained, including one or more pancreatic enzymes, one or more hydrophilic low-melting polymers and eventual excipients, have an high enzymatic activity, bio-availability and stability.