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    Producing method for peptide with amino acid ionic liquid
    1.
    发明专利
    Producing method for peptide with amino acid ionic liquid 有权
    用氨基酸液体制备肽的方法

    公开(公告)号：JP2014139149A

    公开(公告)日：2014-07-31

    申请号：JP2013008762

    申请日：2013-01-21

    申请人： Ajinomoto Co Inc ,  味の素株式会社

    发明人： FURUKAWA SHINYA ,  NAKATANI RYOTARO ,  INAYAMA TAKASHI

    IPC分类号： C07K1/02

    CPC分类号： Y02P20/542

    摘要： PROBLEM TO BE SOLVED: To provide a producing method for synthesizing a peptide under the presence of one or more substance selected from organic acids in which a part or all of hydrogen halides or hydrogen atoms are substituted with halogen and salts of the organic acids, with using ionic liquid at high concentration and in high yield.SOLUTION: There is provided a producing method for a peptide, in which (A) a first amino acid or peptide converted into ionic liquid, (B) a second amino acid or peptide, or ester thereof, and (C) one or more substance selected from organic acids in which a part or all of hydrogen halides or hydrogen atoms are substituted with halogen and salts of the organic acids are provided in a reaction field, herein, the first amino acid or peptide converted into ionic liquid is used as a reaction solvent and reaction ingredient, and a peptide bond is formed between the first amino acid or peptide and the second amino acid or peptide, or ester thereof.

    摘要翻译： 要解决的问题：提供一种在一种或多种选自卤素或氢原子的一部分或全部被卤素和有机酸的盐的有机酸存在下合成肽的制备方法， 以高浓度和高产率使用离子液体。解决方案：提供一种肽的制备方法，其中（A）第一个氨基酸或肽转化为离子液体，（B）第二个氨基酸或肽，或 酯，和（C）选自有机酸的一种或多种物质，其中一部分或全部卤化氢或氢原子被卤素取代，有机酸的盐被提供在反应领域中，本文中，第一个氨基酸 或转化成离子液体的肽用作反应溶剂和反应成分，并且在第一氨基酸或肽与第二氨基酸或肽或其酯之间形成肽键。