公开(公告)号：JPH1029967A

公开(公告)日：1998-02-03

申请号：JP2948497

申请日：1997-02-14

申请人： CIBA GEIGY AG

发明人： BREITSCHUH RICHARD

IPC分类号： C07D213/84 ,  A61K31/00 ,  A61K31/357 ,  A61K31/36 ,  A61K31/415 ,  A61K31/4164 ,  A61K31/4168 ,  A61K31/505 ,  A61P19/00 ,  A61P19/08 ,  A61P19/10 ,  B01J31/02 ,  C07B61/00 ,  C07C45/51 ,  C07C45/63 ,  C07C45/67 ,  C07C45/71 ,  C07C49/747 ,  C07C49/755 ,  C07C253/00 ,  C07C253/20 ,  C07C253/30 ,  C07C255/50 ,  C07C255/52 ,  C07C281/12 ,  C07C281/18 ,  C07C337/08 ,  C07D217/22 ,  C07D233/52 ,  C07D239/18 ,  C07D239/42 ,  C07D317/70

摘要： PROBLEM TO BE SOLVED: To obtain an aromatic nitrile by reacting an aldehyde with hydroxylamine sulfate under specific condition. SOLUTION: The objective nitrile of the formula II is produced by reacting an aldehyde of the formula I (X is CH or N; R1 and R2 are each H, Cl, Br, a 1-6C alkyl, a 1-6C alkoxy, a 1-6C alkyl-amino, CN, phenyl, phenoxy or dimethylamino or R1 and R2 together form a condensed benzene ring, etc.) with hydroxylamine sulfate and dehydrating the reaction product. The reaction is carried out in an organic solvent immiscible with water (e.g. toluene) in the presence of a t-amine base of the formula III (R3 and R4 are each H, methyl or ethyl), etc., at 100-160 deg.C while distilling out water isolated by the reaction under a pressure of 0.02-1.5bar and removing the ammonium salt. The compound of the formula II is useful as a synthetic intermediate for a diketopyrrolopyrrole pigment.