公开(公告)号：JP2011148745A

公开(公告)日：2011-08-04

申请号：JP2010012418

申请日：2010-01-22

Applicant: Kinki Univ ,  Taiyo Corp ,  大洋香料株式会社 ,  学校法人近畿大学

Inventor： UCHIUMI RYUTARO ,  EGUCHI YOKO ,  TANAKA YASUO ,  HIRASE SOTA

IPC: A61K31/015 ,  A23L1/30 ,  A61K8/31 ,  A61P1/02 ,  A61P17/16 ,  A61P31/04 ,  A61P31/10 ,  A61Q11/00 ,  C11D3/18 ,  C11D7/24

Abstract: PROBLEM TO BE SOLVED: To provide a biofilm formation inhibitor showing an effect from very extremely low concentration, without killing bacteria etc., and exhibiting the effect only under a specific condition. SOLUTION: This biofilm formation inhibitor contains a specific sesquiterpene compound as an active ingredient. COPYRIGHT: (C)2011,JPO&INPIT

Abstract translation: 要解决的问题：提供一种生物膜形成抑制剂，其显示非常低浓度的效果，而不杀死细菌等，并且仅在特定条件下表现出效果。 解决方案：该生物膜形成抑制剂含有特定的倍半萜化合物作为活性成分。 版权所有（C）2011，JPO＆INPIT

公开(公告)号：JP2011201843A

公开(公告)日：2011-10-13

申请号：JP2010073513

申请日：2010-03-26

Applicant: Institute Of Microbial Chemistry ,  Kinki Univ ,  公益財団法人微生物化学研究会 ,  学校法人近畿大学

Inventor： IGARASHI MASAYUKI ,  UCHIUMI RYUTARO ,  WATANABE TAKASHI

IPC: C07D407/12 ,  A61K31/357 ,  A61P31/04 ,  A61P43/00 ,  C12N1/20 ,  C12N9/99 ,  C12P17/16 ,  C12R1/465

CPC classification number: Y02P20/52

Abstract: PROBLEM TO BE SOLVED: To provide a new antibacterial agent, i.e., a compound having an excellent anti-bacterial activity against the wide varieties of pathogenic bacteria such as drug resistant bacteria, vegetable pathogenic bacteria, etc., or having an enzyme inhibitory activity against the enzyme which the bacteria have, by inhibiting the two component-controlling system of bacteria, a method for producing the same, a microorganism which is a producing bacterium of the compound, and a compound-containing composition, an anti-bacterial agent and an enzyme activity inhibitor by utilizing the compound.SOLUTION: This compound having a specific anthraquinone back bone is provided. The method for producing the same is provided by comprising a step of culturing the microorganism belonging to the genus Streptomyces and having a function of producing the compound and a collection step of collecting the compound from the cultured material obtained from the culturing step.

Abstract translation: 要解决的问题：提供一种新的抗菌剂，即对各种病原菌如耐药细菌，植物病原菌等具有优良的抗细菌活性的化合物，或具有针对 细菌所具有的酶，通过抑制细菌的双组分控制体系，其制备方法，作为该化合物的生产菌的微生物，含有化合物的组合物，抗菌剂和 提供了利用该化合物的酶活性抑制剂。溶液：提供具有特定蒽醌背骨的化合物。 其制造方法通过包括培养属于链霉菌属的微生物并具有生产该化合物的功能的步骤和从培养步骤获得的培养物中收集化合物的收集步骤来提供。

公开(公告)号：JP2011055721A

公开(公告)日：2011-03-24

申请号：JP2009205961

申请日：2009-09-07

Applicant: Kinki Univ ,  Kirin Holdings Co Ltd ,  キリンホールディングス株式会社 ,  学校法人近畿大学

Inventor： UCHIUMI RYUTARO ,  AMARI HONEN ,  OKAMOTO TAKASHI ,  HARADA HISASHI ,  MISAWA NORIHIKO

IPC: C12N15/09 ,  C12N1/21 ,  C12P7/02 ,  C12P7/26 ,  C12Q1/48

Abstract: PROBLEM TO BE SOLVED: To provide a means for producing oxidized sesquiterpene by obtaining an enzyme gene necessary for synthesizing zerumbone from α-humulene and by using the obtained gene. SOLUTION: There are disclosed a Zingiber zerumbet Smith-originated cytochrome P450 gene encoding a polypeptide with activity of converting α-humulene into 8-hydroxy-α-humulene, and a Zingiber zerumbet Smith-originated dehydrogenase gene encoding a polypeptide with the activity of converting the 8-hydroxy-α-humulene into zerumbone. COPYRIGHT: (C)2011,JPO&INPIT

Abstract translation: 待解决的问题：提供通过获得从α-葎草酮合成er umb酮所必需的酶基因并通过使用获得的基因来制备氧化倍半萜的方法。 解决方案：公开了编辑具有将α-葎草酮转化为8-羟基-α-葎草酮的活性的多肽的Zingiber zerumbet Smith起源的细胞色素P450基因，以及编码多肽的Zingiber Zerumbet Smith起始的脱氢酶基因， 将8-羟基-α-葎草酮转化为er umb酮的活性。 版权所有（C）2011，JPO＆INPIT

公开(公告)号：JP2011036182A

公开(公告)日：2011-02-24

申请号：JP2009186724

申请日：2009-08-11

Applicant: Kinki Univ ,  Microbial Chem Res Found ,  学校法人近畿大学 ,  財団法人微生物化学研究会

Inventor： IGARASHI MASAYUKI ,  UCHIUMI RYUTARO

IPC: C12N9/99 ,  A61K31/194 ,  A61P31/04 ,  A61P43/00 ,  C07C59/90 ,  C12N1/20 ,  C12P15/00 ,  C12R1/465

CPC classification number: Y02P20/52

Abstract: PROBLEM TO BE SOLVED: To provide a compound exhibiting excellent antibacterial activity in wide pathogenic bacteria such as drug-resistant bacteria and plant pathogenic bacteria by inhibiting two component-regulating system of the bacteria, or enzyme-inhibiting activity to the enzyme possessed by the bacteria, to provide a method for producing the compound, to provide a microorganism of a producing microorganism of the compound, and to provide a composition, an antibacterial agent and an enzyme activity inhibitor, utilizing the compound. SOLUTION: The new enzyme activity inhibitor is produced by MK632-100F11 strain of Streptomyces sp. of accession number NITEP-777. COPYRIGHT: (C)2011,JPO&INPIT

Abstract translation: 要解决的问题：通过抑制细菌的两种组分调节体系或对所具有的酶的酶抑制活性来提供在广病病菌如耐药细菌和植物病原菌中表现出优异的抗菌活性的化合物 通过细菌提供化合物的制备方法，提供化合物的生产微生物的微生物，并提供利用该化合物的组合物，抗菌剂和酶活性抑制剂。 解决方案：新的酶活性抑制剂由链霉菌属的MK632-100F11菌株生产。 的登录号NITEP-777。 版权所有（C）2011，JPO＆INPIT

公开(公告)号：JP2010222292A

公开(公告)日：2010-10-07

申请号：JP2009070695

申请日：2009-03-23

Applicant: Kinki Univ ,  Microbial Chem Res Found ,  学校法人近畿大学 ,  財団法人微生物化学研究会

Inventor： IGARASHI MASAYUKI ,  UCHIUMI RYUTARO ,  HATANO KAZUKI ,  WATANABE TAKASHI

IPC: A01N43/36 ,  A01P3/00

Abstract: PROBLEM TO BE SOLVED: To provide a plant disease controlling agent excellent in the effectiveness against plant diseases.
SOLUTION: The plant disease controlling agent contains at least any one of signamycin A and signamycin B.
COPYRIGHT: (C)2011,JPO&INPIT

Abstract translation: 待解决的问题：提供对植物病害有效性优异的植物病害防治剂。 解决方案：植物病害防治剂含有至少任何一种西格马霉素A和西格玛霉素B.版权所有（C）2011，JPO＆INPIT

公开(公告)号：JP2009005678A

公开(公告)日：2009-01-15

申请号：JP2007312289

申请日：2007-12-03

Applicant: Univ Kinki ,  学校法人近畿大学

Inventor： UCHIUMI RYUTARO

IPC: C12N15/09 ,  C12N9/00 ,  C12P5/00

CPC classification number: Y02P20/52

Abstract: PROBLEM TO BE SOLVED: To provide an enzyme synthesizing sesquiterpenes, a gene encoding the enzyme, a vector and a cell containing the gene, and a method for producing sesquiterpenes by using the vector, etc. SOLUTION: Provided are a polypeptide originated from Zingiber zerumbet and having sesquiterpene synthase activity, a gene encoding the polypeptide, a vector containing the gene, a cell containing the vector introduced therein, and a method for producing a sesquiterpene, especially α-humulene and β-eudesmol by using a cell or a plant containing the gene introduced therein. COPYRIGHT: (C)2009,JPO&INPIT

Abstract translation: 待解决的问题：提供合成倍半萜的酶，编码酶，载体和含有该基因的细胞的基因，以及使用载体等制备倍半萜的方法。解决方案：提供 来自Zingiber zerumbet并且具有倍半萜烯合酶活性的多肽，编码多肽的基因，含有该基因的载体，含有载体的细胞，以及通过使用以下方法制备倍半萜烯，特别是α-葎草酯和β-桦木醇的方法 含有引入其中的基因的细胞或植物。 版权所有（C）2009，JPO＆INPIT

公开(公告)号：JP2009207376A

公开(公告)日：2009-09-17

申请号：JP2008051539

申请日：2008-03-03

Applicant: Kirin Holdings Co Ltd ,  Univ Kinki ,  キリンホールディングス株式会社 ,  学校法人近畿大学

Inventor： HARADA HISASHI ,  MISAWA NORIHIKO ,  UCHIUMI RYUTARO

IPC: C12N1/21 ,  C12N15/09 ,  C12P5/00 ,  C12P23/00

Abstract: PROBLEM TO BE SOLVED: To provide a method for efficiently producing isoprenoids using Escherichia coli.
SOLUTION: Provided are a recombinant Escherichia coli obtained by transferring and expressing (1) the gene or gene group of an enzyme for synthesizing isoprenoids from farnesyl diphosphate, (2) type 2 isopentenyl diphosphate isomerase gene, and (3) a mevalonic acid route gene group for synthesizing isopentenyl diphosphate from acetoacetyl-coenzyme A; and the method for producing the isoprenoids, characterized by culturing the recombinant Escherichia coli in a culture medium containing acetoacetate and then obtaining the isoprenoids from the culture product or the bacterial cells.
COPYRIGHT: (C)2009,JPO&INPIT

Abstract translation: 要解决的问题：提供使用大肠杆菌有效生产类异戊二烯的方法。 提供了通过转移和表达（1）用于从法呢二磷酸合成类异戊二烯的基因或基因组，（2）异戊烯基二磷酸异构酶基因2型和（3）甲羟戊酸 用于从乙酰乙酰辅酶A合成异戊烯基二磷酸的酸路由基因组; 以及用于制备类异戊二烯的方法，其特征在于在含有乙酰乙酸酯的培养基中培养重组大肠杆菌，然后从培养产物或细菌细胞获得类异戊二烯。 版权所有（C）2009，JPO＆INPIT

公开(公告)号：JP2009173599A

公开(公告)日：2009-08-06

申请号：JP2008015318

申请日：2008-01-25

Applicant: Univ Kinki ,  学校法人近畿大学

Inventor： UCHIUMI RYUTARO ,  KANO KANEO ,  ADACHI KYOKO ,  SHIZURI YOSHIICHI

IPC: C07D493/10 ,  A61K31/357 ,  A61P31/04 ,  C12N1/14 ,  C12P17/16 ,  C12R1/645

Abstract: PROBLEM TO BE SOLVED: To provide a new and effective antibacterial agent and antibiotic.
SOLUTION: A new spiro-oxynaphthalene obtained from marine fungi, an extract comprising the same, and an antibacterial agent etc., comprising the same are provided.
COPYRIGHT: (C)2009,JPO&INPIT

Abstract translation: 要解决的问题：提供一种新的有效的抗菌剂和抗生素。 解决方案：提供从海洋真菌获得的新的螺 - 氧萘，其包含其的提取物和抗菌剂等。 版权所有（C）2009，JPO＆INPIT

公开(公告)号：JP2006056787A

公开(公告)日：2006-03-02

申请号：JP2004237458

申请日：2004-08-17

Applicant: Univ Kinki ,  学校法人近畿大学

Inventor： UCHIUMI RYUTARO ,  KITAYAMA TAKASHI

IPC: A61K45/00 ,  A61K31/4164 ,  A61P31/04 ,  C07D233/58 ,  C12N15/09 ,  C12Q1/04 ,  G01N33/15 ,  G01N33/50

Abstract: PROBLEM TO BE SOLVED: To simplify a screening method using a gene transcription regulation system and based on the mechanism of a two-component singnaling system of bacteria and to provide an imidazole compound useful as an antibacterial agent against bacteria which have resistance to conventional antibiotics.
SOLUTION: The simple screening method for a compound which inhibits the dimerization of histidinekinase in a two-component signaling system of a bacteria comprises adding a candidate to Escherichia coli transformed by a vector which is a gene transcription regulation system having an iclR promoter and an IclR represser, wherein the homodimer formation domain of the represser is substituted by the homodimer formation domain of histidinekinase, and the promoter has a base sequence having a linked GFP (green fluorescent protein) coding base sequence downstream thereof, culturing the bacteria, and measuring the fluorescent intensity. 1-Dodecyl-2-isopropylimidazole which is an antibacterial agent obtained by screening by the method is also provided.
COPYRIGHT: (C)2006,JPO&NCIPI

Abstract translation: 要解决的问题：为了简化使用基因转录调节系统的筛选方法，并且基于双组分细菌系统的机制，并提供可用作抗细菌抗菌剂的咪唑化合物，其具有抗性 常规抗生素。 解决方案：抑制细菌的双组分信号传导系统中组氨酸激酶二聚化的化合物的简单筛选方法包括将候选物加入由具有iclR启动子的基因转录调节系统的载体转化的大肠杆菌 以及IclR抑制剂，其中所述阻遏物的同源二聚体形成结构域被组氨酸激酶的同型二聚体形成结构域取代，并且启动子具有在其下游具有连接的GFP（绿色荧光蛋白）编码碱基序列的碱基序列，培养细菌，以及 测量荧光强度。 还提供了通过该方法筛选获得的抗菌剂的1-十二烷基-2-异丙基咪唑。 版权所有（C）2006，JPO＆NCIPI