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公开(公告)号：JPH04346991A
公开(公告)日：1992-12-02
申请号：JP15105791
申请日：1991-05-27
申请人： LION CORP
摘要： PURPOSE:To obtain a cyanogenation product useful as a raw material for medicines, agricultural chemicals, etc., in high yield by using a Lewis base as a catalyst in cyanogenating a nucleophilic reaction-accepting compound with a tri-substituted silylanilide. CONSTITUTION:A nucleophilic reaction-accepting compound such as an aldehyde is silylated with a tri-substituted silylanilide (e.g. trimethylsilylanilide) by using a Lewis base (preferably a triarylphosphine, a triarylaricine, etc.) as a cyanogenating reaction catalyst. The aforementioned silylating reaction is preferably carried out at -78 deg.C to ambient temperature by using methylene chloride as a solvent. The Lewis base catalyst is used in an amount of preferably 0.1-0.3mol based on 1mol nucleophilic reaction-accepting compound.
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公开(公告)号：JPH06145092A
公开(公告)日：1994-05-24
申请号：JP32592592
申请日：1992-11-11
申请人： LION CORP
发明人： SUZUKI KAORU , MUKOYAMA MITSUAKI
摘要： PURPOSE:To obtain an aromatic ketone compound by smooth acylation of an aromatic compound in the presence of a Lewis acid using, as acylating agent, a carboxylic acid or trisubstituted silyl carboxylic ester. CONSTITUTION:The aromatic ketone compound can be obtained by acylating an aromatic compound with a Friedel Crafts-type acylating agent (a carboxylic acid or trisubstituted silyl carboxylic ester) in the presence of a Lewis acid catalyst in a solvent (p-trifluoromethylbenzoic acid anhydride).
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3.发明专利
公开(公告)号：JPH04295455A
公开(公告)日：1992-10-20
申请号：JP8483291
申请日：1991-03-25
申请人： LION CORP
IPC分类号： B01J31/02 , B01J31/18 , C07B61/00 , C07C253/00 , C07C255/12 , C07C255/31 , C07C255/36 , C07C255/42 , C07D453/04
摘要： PURPOSE:To obtain the objective compound in high yield and readily in production of a cyano compound useful as a raw material especially for medicines, agricultural chemicals and liquid crystal substance by cyanating a nucleophilic reaction accepting compound with a trisubstituted silylanilide by using a specific catalyst. CONSTITUTION:In cyanating a nucleophilic reaction accepting compound such as carbonyl compound, e.g. aldehyde or ketone, imine compound or nitroolefin compound, preferably aldehyde with a trisubstituted silylanilide, a Lewis base such as organic amine compound, organic phosphorus compound, organic arsenic compound or organic antimony compound, preferably cinchonine or a derivative thereof, especially a cinchonine derivative shown by the formula (Tb is trifluoromethanesulfonic acid residue) as an asymmetric synthetic catalyst to improve yield, especially optical yield of the objective compound. The catalyst for asymmetric synthesis is readily obtainable and more stably and inexpensively supplied than existing catalysts for asymmetric synthesis.
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